| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s118_67V6.1 |
| Family | GH79 |
| Protein Properties | Length: 563 Molecular Weight: 61856.3 Isoelectric Point: 6.3207 |
| Chromosome | Chromosome/Scaffold: 118 Start: 363775 End: 368155 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 64 | 550 | 0 |
| DEAFICATLDWWPPDKCDYGTCSWGQSSLLNLDLANPLLEKSLKALQPFRIRLGGTLQDHIVYDIGLSPSQSCLPIVKDGTDMFGFREGCLSMERWIALN TLFSKTGSLAVFGLNALINRPQVGGVWGPWDSSNARDFIKFTIDQDIQVDAWELGNELTANGVGTSISAEQYARDVMELRLIIDSLYEGFTRRPLLVAPD GFFNPQWFTRFLNASGPGVVDVVTRHIYNLGPGVSNDLVEKILNSTYLDNELGHFRAVQEILQTSATSASAWVGEAGGAYNSGHHLVTDAFVFSFWYLDQ LGMAASFNNKVYCRQSLIGGNYGLLNTTSYKPNPDMYSALLWKRLMGTKVLGTTLKGYPQLRTYTHCQQGSTDGVTMMLINLSNSTVNVIANLLSHPKNK PLSHGEKKLKYQLIPKTSKGSRPDLVRFEYHLSAPQQDLHSQTTLLNGVPLELTSTGDFPSMDPVVKENSSPVSIPPLSIVFVVLSD | |||
| Full Sequence |
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| Protein Sequence Length: 563 Download |
| MESTHEHPSF IRLIRWLVWV SVLVSASAKH DSCSNSKKSC AKNDGDDGIL VVEVEGSAIL 60 ATTDEAFICA TLDWWPPDKC DYGTCSWGQS SLLNLDLANP LLEKSLKALQ PFRIRLGGTL 120 QDHIVYDIGL SPSQSCLPIV KDGTDMFGFR EGCLSMERWI ALNTLFSKTG SLAVFGLNAL 180 INRPQVGGVW GPWDSSNARD FIKFTIDQDI QVDAWELGNE LTANGVGTSI SAEQYARDVM 240 ELRLIIDSLY EGFTRRPLLV APDGFFNPQW FTRFLNASGP GVVDVVTRHI YNLGPGVSND 300 LVEKILNSTY LDNELGHFRA VQEILQTSAT SASAWVGEAG GAYNSGHHLV TDAFVFSFWY 360 LDQLGMAASF NNKVYCRQSL IGGNYGLLNT TSYKPNPDMY SALLWKRLMG TKVLGTTLKG 420 YPQLRTYTHC QQGSTDGVTM MLINLSNSTV NVIANLLSHP KNKPLSHGEK KLKYQLIPKT 480 SKGSRPDLVR FEYHLSAPQQ DLHSQTTLLN GVPLELTSTG DFPSMDPVVK ENSSPVSIPP 540 LSIVFVVLSD AKVSICSTQQ RG* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 5.0e-151 | 51 | 365 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_001767170.1 | 0 | 50 | 558 | 35 | 537 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001769830.1 | 0 | 1 | 562 | 1 | 562 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001770123.1 | 0 | 39 | 556 | 4 | 525 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001774747.1 | 0 | 43 | 557 | 9 | 524 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_002515478.1 | 0 | 52 | 556 | 17 | 522 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0005 | 76 | 452 | 36 | 404 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vnz_A | 0.0005 | 76 | 452 | 36 | 404 | A Chain A, Pectin Methylesterase Pema From Erwinia Chrysanthemi |
| PDB | 3vny_A | 0.0005 | 76 | 452 | 36 | 404 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
