Basic Information | |
---|---|
Species | Physcomitrella patens |
Cazyme ID | Pp1s237_53V6.1 |
Family | GT47 |
Protein Properties | Length: 454 Molecular Weight: 52333.7 Isoelectric Point: 7.7073 |
Chromosome | Chromosome/Scaffold: 237 Start: 416254 End: 419233 |
Description | Exostosin family protein |
View CDS |
External Links |
---|
NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
---|---|---|---|
Family | Start | End | Evalue |
GT47 | 77 | 393 | 0 |
PLKVYMYDIPRKFNFGLMTMDNKNEDLPWGNHAAPPWSQQWEVNKQHSVEYWMTVYLLDGWDRKDGRRAAIRVRDPYQADVFFVPFFASLSFNNYGYGME GPGAELDKNLQECVVNILLNSKWWKASQGRDHVIVLHHPNAFRHYRHLLNSSMLIVADFGRFSTDVACLQKDIVAPYEHVVQSYVDDHSNSFSQRHILLY FQGRIHRKADGIVRAKLAKALMNEKDVHYMDSEASSEALAEATSGMRSSRFCLHPAGDTPSSCRLFDAIVSHCVPVIVSDRIELPFEDDIDYNEFSLFFS SEEAVRPQYLLRILRGI |
Full Sequence |
---|
Protein Sequence Length: 454 Download |
MVRYGGKLAV YGIVVLCITA LLVGLAMLIP DEIAHYYGQF SEFSQGDANK PSWFLWSLPR 60 KSDDGSITRL KRSCSHPLKV YMYDIPRKFN FGLMTMDNKN EDLPWGNHAA PPWSQQWEVN 120 KQHSVEYWMT VYLLDGWDRK DGRRAAIRVR DPYQADVFFV PFFASLSFNN YGYGMEGPGA 180 ELDKNLQECV VNILLNSKWW KASQGRDHVI VLHHPNAFRH YRHLLNSSML IVADFGRFST 240 DVACLQKDIV APYEHVVQSY VDDHSNSFSQ RHILLYFQGR IHRKADGIVR AKLAKALMNE 300 KDVHYMDSEA SSEALAEATS GMRSSRFCLH PAGDTPSSCR LFDAIVSHCV PVIVSDRIEL 360 PFEDDIDYNE FSLFFSSEEA VRPQYLLRIL RGINETKWTQ MWTKLKAVSH HFEFQHPAKK 420 DDAVNMIFKQ VQRKLPSMKL AAHRSERLQI EDW* |
Functional Domains Download unfiltered results here | ||||||||
---|---|---|---|---|---|---|---|---|
Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 4.0e-64 | 74 | 393 | 329 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
---|---|
GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
---|---|---|---|---|---|---|---|
Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABK24530.1 | 0 | 74 | 453 | 62 | 442 | unknown [Picea sitchensis] |
RefSeq | XP_001754933.1 | 0 | 82 | 453 | 1 | 373 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_001778357.1 | 0 | 70 | 453 | 23 | 406 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_001781620.1 | 0 | 52 | 453 | 46 | 459 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_002512333.1 | 0 | 52 | 453 | 30 | 430 | catalytic, putative [Ricinus communis] |