PlantCAZyme

Basic Information
Species	Physcomitrella patens
Cazyme ID	Pp1s2536_2V6.1
Family	GH125
Protein Properties	Length: 461 Molecular Weight: 52252.9 Isoelectric Point: 5.453
Chromosome	Chromosome/Scaffold: 2536 Start: 810 End: 8478
Description
View CDS

External Links
NCBI Taxonomy
Plaza
CAZyDB

Signature Domain Download full data set without filtering

Family	Start	End	Evalue
GH125	50	154	2.5e-40
PKLLQLFKNCFPNTLETTTKLMDDGTTFVITGDIPASWLRDSVEQVMHYVPFAKEDAALQRMIGGLVKRHIQYIHIDPYANAFNESANDWHWNKADVTDM GPWVL

Full Sequence
Protein Sequence Length: 461 Download
DQPGAYDHVY KRRSRMEQFR LPQINMPRME LPASIQNVLT EAEEKLSHRP KLLQLFKNCF 60 PNTLETTTKL MDDGTTFVIT GDIPASWLRD SVEQVMHYVP FAKEDAALQR MIGGLVKRHI 120 QYIHIDPYAN AFNESANDWH WNKADVTDMG PWVLGILFAN WYSNGNEVPA DPGEAKEFWQ 180 RKLADAAKYA STGELLFMNG CDHQPIQLDL PEAIRTAREL FPDTDFVHSN FIDYLAALES 240 SLDRELSSVR GELRSQRTDG WGTLVNTASS RVYLKQLNQR GQAMLEKVAE PLAAYASLLG 300 AAYPHDLLQY AWKTLMQNHP HDSICGCSVD EVHREMVTRF EKSRHVAEAV ADDSLQSIAE 360 HIDTTGFAAF GPDAVPFTVF NTTGGTRTGT VSVEVDVLRH YFREGIPFGE MKSRVKQLEL 420 ADRIVVDSEG RKVDCTITDL GLQFGYDLPD DKFRQPYFAR K

Full Sequence

Protein Sequence Length: 461 Download

DQPGAYDHVY KRRSRMEQFR LPQINMPRME LPASIQNVLT EAEEKLSHRP KLLQLFKNCF    60
PNTLETTTKL MDDGTTFVIT GDIPASWLRD SVEQVMHYVP FAKEDAALQR MIGGLVKRHI    120
QYIHIDPYAN AFNESANDWH WNKADVTDMG PWVLGILFAN WYSNGNEVPA DPGEAKEFWQ    180
RKLADAAKYA STGELLFMNG CDHQPIQLDL PEAIRTAREL FPDTDFVHSN FIDYLAALES    240
SLDRELSSVR GELRSQRTDG WGTLVNTASS RVYLKQLNQR GQAMLEKVAE PLAAYASLLG    300
AAYPHDLLQY AWKTLMQNHP HDSICGCSVD EVHREMVTRF EKSRHVAEAV ADDSLQSIAE    360
HIDTTGFAAF GPDAVPFTVF NTTGGTRTGT VSVEVDVLRH YFREGIPFGE MKSRVKQLEL    420
ADRIVVDSEG RKVDCTITDL GLQFGYDLPD DKFRQPYFAR K 

Functional Domains Download unfiltered results here

Cdd ID	Domain	E-Value	Start	End	Length	Domain Description
PRK09819	PRK09819	5.0e-34	162	439	284	+ alpha-mannosidase; Provisional
pfam06824	DUF1237	2.0e-42	50	154	108	+ Protein of unknown function (DUF1237). This family contains a number of hypothetical proteins of about 450 residues in length. Their function is unknown, and most are bacterial. However, structurally this family is part of the 6 hairpin glycosidase superfamily, suggesting a glycosyl hydrolase function.
COG3538	COG3538	2.0e-46	26	153	128	+ Uncharacterized conserved protein [Function unknown]
cd10814	GH38N_AMII_SpGH38_like	9.0e-47	153	257	105	+ N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38). The subfamily is represented by SpGH38 of Streptococcus pyogenes, which has been assigned as a putative alpha-mannosidase, and is encoded by ORF spy1604. SpGH38 appears to exist as an elongated dimer and display alpha-1,3 mannosidase activity. It is active on disaccharides and some aryl glycosides. SpGH38 can also effectively deglycosylate human N-glycans in vitro. A divalent metal ion, such as a zinc ion, is required for its activity. SpGH38 is inhibited by swainsonine. The absence of any secretion signal peptide suggests that SpGH38 may be intracellular.
COG0383	AMS1	3.0e-64	126	461	355	+ Alpha-mannosidase [Carbohydrate transport and metabolism]

Gene Ontology
GO Term	Description
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0008270	zinc ion binding

Annotations - NR Download unfiltered results here
Source	Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
RefSeq	XP_001786550.1	0	1	461	182	642	predicted protein [Physcomitrella patens subsp. patens]
RefSeq	YP_003014270.1	0	130	461	167	496	glycoside hydrolase family 38 [Paenibacillus sp. JDR-2]
RefSeq	YP_003241966.1	0	130	461	164	491	glycoside hydrolase family 38 [Geobacillus sp. Y412MC10]
RefSeq	ZP_02328127.1	0	129	461	164	493	glycosyl hydrolase, family 38 [Paenibacillus larvae subsp. larvae BRL-230010]
RefSeq	ZP_04851765.1	0	130	461	164	492	glycoside hydrolase [Paenibacillus sp. oral taxon 786 str. D14]

Annotations - PDB Download unfiltered results here
Source	Hit ID	E-Value	Query Start	Query End	Hit Start	Hit End	Description
PDB	2wyi_B	0	153	461	205	513	A Chain A, Endo-glycoceramidase Ii From Rhodococcus Sp.: Ganglioside Gm3 Comp
PDB	2wyi_A	0	153	461	205	513	A Chain A, Endo-glycoceramidase Ii From Rhodococcus Sp.: Ganglioside Gm3 Comp
PDB	2wyh_B	0	153	461	205	513	A Chain A, Structure Of The Streptococcus Pyogenes Family Gh38 Alpha- Mannosidase
PDB	2wyh_A	0	153	461	205	513	A Chain A, Structure Of The Streptococcus Pyogenes Family Gh38 Alpha- Mannosidase
PDB	3lvt_A	0	141	460	177	488	A Chain A, The Crystal Structure Of A Protein In The Glycosyl Hydrolase Family 38 From Enterococcus Faecalis To 2.55a

EST Download unfiltered results here

Hit	Length	Start	End	EValue
CO064488	85	54	137	2e-19
CO063237	88	51	137	9e-19
FQ822921	88	51	133	4e-17
EC156871	113	35	132	0.0000000000007
EX868424	129	35	132	0.00000000002

Orthologous Group
Species	ID
Chlamydomonas reinhardtii	g9090.t1
Volvox carteri	Vocar20005683m

CAZyme Information