Basic Information | |
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Species | Physcomitrella patens |
Cazyme ID | Pp1s306_31V6.1 |
Family | GT47 |
Protein Properties | Length: 571 Molecular Weight: 65428.2 Isoelectric Point: 6.4351 |
Chromosome | Chromosome/Scaffold: 306 Start: 140419 End: 142621 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 241 | 520 | 0 |
KRKLRIFVYPHDRKDPFHMIFESGNKVPSGNYASEEFFQQSLLTSTFLTKTASEADFFFMPVSITKARMDKRINVGGLQSFCANYITDVRSQWSYWNRSN GADHFYLSCHSIARNAMDRVPDVRQNAIQLLCPASYFLPSYITHKDASVPQIWPRLGKEPEEVRTITQRKRLAFFAGALNSPVRKDLERTWANDSKILVH KGRVPYPYSEALLTTKFCLHAKGFEVNTARLGDAMYYGCVPVVIANYYDLPFQDILDWTKFSIVVSSLDIPLLKKTLEAV |
Full Sequence |
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Protein Sequence Length: 571 Download |
MARSGLLEDG GNLFSELGRT RKRNGSNSKP GRGICLLLVT VFFTLLLASR LLWCFMYLFN 60 STATVMYVDH HTVHPNRDSA AFAGENETKA MGEGTIVREL GRKANESEHD QILEDSEEKI 120 VDDHVDEKEG SMVDTNVGNK RAEIEEVWKD EEQLGELMAK MTNMVVKLGD GKEEEEEDKE 180 ENDDSVEKVA LDNGHAEKMK LPDAIAFLEQ LAGKLTKTGV HEDYGPYHSR RIFESDYAEM 240 KRKLRIFVYP HDRKDPFHMI FESGNKVPSG NYASEEFFQQ SLLTSTFLTK TASEADFFFM 300 PVSITKARMD KRINVGGLQS FCANYITDVR SQWSYWNRSN GADHFYLSCH SIARNAMDRV 360 PDVRQNAIQL LCPASYFLPS YITHKDASVP QIWPRLGKEP EEVRTITQRK RLAFFAGALN 420 SPVRKDLERT WANDSKILVH KGRVPYPYSE ALLTTKFCLH AKGFEVNTAR LGDAMYYGCV 480 PVVIANYYDL PFQDILDWTK FSIVVSSLDI PLLKKTLEAV TDEQYAELHR QVLLARKHFQ 540 WHAPPEEYDA FHTVMYELWK RRHIVRRSTQ * |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 9.0e-64 | 240 | 520 | 296 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABD28410.1 | 0 | 222 | 562 | 137 | 476 | Exostosin-like [Medicago truncatula] |
EMBL | CBI39073.1 | 0 | 228 | 566 | 108 | 444 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_001781578.1 | 0 | 227 | 570 | 1 | 344 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_001781579.1 | 0 | 1 | 218 | 1 | 218 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_002265438.1 | 0 | 227 | 566 | 105 | 442 | PREDICTED: hypothetical protein [Vitis vinifera] |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |