Basic Information | |
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Species | Physcomitrella patens |
Cazyme ID | Pp1s308_9V6.1 |
Family | GT47 |
Protein Properties | Length: 505 Molecular Weight: 57420.8 Isoelectric Point: 5.7276 |
Chromosome | Chromosome/Scaffold: 308 Start: 257362 End: 259118 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 238 | 455 | 1.4013e-45 |
PFHDPSKADFFLMPISITKARLDKRIDVGGLQKFCTKYVQDMRSQWNYWNRSSGTDHFYLSCHSIARNAMDGIPEVRQNAIQLLCPASYFLAYNITHKDA SVPQIWPRIGREPKEVGTITQRTRLAFFAGALNSPARQVLKTIWGNDDKIFVQDGRTPFPYSEGLLTSKFCLHVKGCVPVVIANYYDLPFQDILDWTKFS LVVSSLDISQLKDILEAV |
Full Sequence |
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Protein Sequence Length: 505 Download |
MSLDGYKISE SGRHRKRISS VSKTGRSLLP LMVAVVCALL LTGRLLWCFT YLINGDETGI 60 LVGPHRTNTS RADAGVLGNR ESHGSIKVEE IFPRAAVQEE VTRDNEEEFE DDIKDNKADG 120 IEGSSEGMTY AEEKLEVETK IGEETTETVN IDLNPGDEGE IDEEEALTRD NEDQEGSVRM 180 DKFPDAIAYL EELAANLTSK GVEDDDGPYH SRRIFESDFA AMKRNFRIFV YPHDERNPFH 240 DPSKADFFLM PISITKARLD KRIDVGGLQK FCTKYVQDMR SQWNYWNRSS GTDHFYLSCH 300 SIARNAMDGI PEVRQNAIQL LCPASYFLAY NITHKDASVP QIWPRIGREP KEVGTITQRT 360 RLAFFAGALN SPARQVLKTI WGNDDKIFVQ DGRTPFPYSE GLLTSKFCLH VKGCVPVVIA 420 NYYDLPFQDI LDWTKFSLVV SSLDISQLKD ILEAVTPQHY AKLHKHVLQA RKHFIWHTPP 480 EEHDAFNTVM YELWKRRHTV GRPL* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 6.0e-40 | 241 | 455 | 244 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABD28410.1 | 0 | 199 | 500 | 132 | 479 | Exostosin-like [Medicago truncatula] |
EMBL | CBI39073.1 | 0 | 210 | 504 | 108 | 447 | unnamed protein product [Vitis vinifera] |
RefSeq | XP_001781578.1 | 0 | 209 | 502 | 1 | 341 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_002265438.1 | 0 | 209 | 504 | 105 | 445 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002525728.1 | 0 | 222 | 500 | 1 | 324 | catalytic, putative [Ricinus communis] |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |