| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s456_4V6.1 |
| Family | GT41 |
| Protein Properties | Length: 962 Molecular Weight: 106944 Isoelectric Point: 6.7803 |
| Chromosome | Chromosome/Scaffold: 456 Start: 63987 End: 70956 |
| Description | Tetratricopeptide repeat (TPR)-like superfamily protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
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| Family | Start | End | Evalue |
| GT41 | 389 | 877 | 0 |
| IKPNFSQSLNNLGVVYTVQGKMDSAAAMIEKAILANPSYAEAYNNLGVLHRDAGNIPLAIDAYERCLLFDPDSRNAGQNRLLAMNYIYESDDDKLYNAHR SWGKRFNRLYPEFTTWSNIKERDRSLTIGYISPDYFTHSVSYFIEAPLLHHDYTHYHIVVYSAVVKTDAKTQRFKETVLKKGGIWREVFGIDEKKLANMV REDKVDILVELTGHTANNRLGVMACRPAPIQATWIGYSNTTGLPTIDYRFTDALADPPTTLQKHVEELVRLPGCFLCYTPSPESGPVVPTPALSNGFVTF GSFNNLAKITPRVLRVWARILIKMPSARLVVKCKPFCCDSVREAFLAKLEELGVESLRIDLLPLILLNHDHMQAYCLMDISLDTFPYAGTTTTCESLYMG VPCVTMAGKVHAHNVGVTLLHQVGLENLVVKTEDEYVDKAIELASNVSSLASLRNGLRERMLSSYLCDGPKFVKGLEEKYLHLWHRYCD | |||
| Full Sequence |
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| Protein Sequence Length: 962 Download |
| MKRNGMGPGT DWPESQVTQP QQTNGIRERE PAIDNHRLKR RPSCGSLTND GNMGLSTARS 60 LPLPTGLVGQ KVPGKDALSF AAVLRSRNKI VDALALYESI LEVEPQNVEA HVGKGICLQL 120 QNLHRPAFES FQNALQLDAQ NACALTHCGM LYKEEGHLLE AAEAYRKALL TEPTYKAASE 180 NLAIVLTDLG TSLKLSGHIQ EGLTKYYDAL KADSRYAPAY YNLGVVYSEM MQYDMALSCY 240 EKAAANRPMY AEAYCNMGVI YKNRGDLDAA ISCYERCLAL SPNFEIAKNN MAIALTDLGT 300 KVKIEGYIHQ GVAYYKKALL YNWHYADAMY NLGVAYGELL KFDMAVVMYE LALHFNPHCA 360 EACNNLGVIY KDRDNLDKAV ECYQMALQIK PNFSQSLNNL GVVYTVQGKM DSAAAMIEKA 420 ILANPSYAEA YNNLGVLHRD AGNIPLAIDA YERCLLFDPD SRNAGQNRLL AMNYIYESDD 480 DKLYNAHRSW GKRFNRLYPE FTTWSNIKER DRSLTIGYIS PDYFTHSVSY FIEAPLLHHD 540 YTHYHIVVYS AVVKTDAKTQ RFKETVLKKG GIWREVFGID EKKLANMVRE DKVDILVELT 600 GHTANNRLGV MACRPAPIQA TWIGYSNTTG LPTIDYRFTD ALADPPTTLQ KHVEELVRLP 660 GCFLCYTPSP ESGPVVPTPA LSNGFVTFGS FNNLAKITPR VLRVWARILI KMPSARLVVK 720 CKPFCCDSVR EAFLAKLEEL GVESLRIDLL PLILLNHDHM QAYCLMDISL DTFPYAGTTT 780 TCESLYMGVP CVTMAGKVHA HNVGVTLLHQ VGLENLVVKT EDEYVDKAIE LASNVSSLAS 840 LRNGLRERML SSYLCDGPKF VKGLEEKYLH LWHRYCDGDV PYETRKKAED EALVSRSAST 900 TGDVTDLPMK EAGSAPHQPN AATITSTSSP TSTLSTTEAN RLDEARMKFP KLSPSSLGPS 960 S* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd00189 | TPR | 7.0e-17 | 327 | 421 | 95 | + Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans in various subcellular locations; involved in a variety of functions including protein-protein interactions, but common features in the interaction partners have not been defined; involved in chaperone, cell-cycle, transciption, and protein transport complexes; the number of TPR motifs varies among proteins (1,3-11,13 15,16,19); 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accomodate an alpha-helix of a target protein; it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes; examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase; three copies of the repeat are present here | ||
| cd00189 | TPR | 1.0e-17 | 294 | 392 | 99 | + Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans in various subcellular locations; involved in a variety of functions including protein-protein interactions, but common features in the interaction partners have not been defined; involved in chaperone, cell-cycle, transciption, and protein transport complexes; the number of TPR motifs varies among proteins (1,3-11,13 15,16,19); 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accomodate an alpha-helix of a target protein; it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes; examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase; three copies of the repeat are present here | ||
| cd00189 | TPR | 5.0e-18 | 185 | 283 | 99 | + Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans in various subcellular locations; involved in a variety of functions including protein-protein interactions, but common features in the interaction partners have not been defined; involved in chaperone, cell-cycle, transciption, and protein transport complexes; the number of TPR motifs varies among proteins (1,3-11,13 15,16,19); 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accomodate an alpha-helix of a target protein; it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes; examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase; three copies of the repeat are present here | ||
| cd00189 | TPR | 5.0e-20 | 361 | 460 | 100 | + Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, plants, and humans in various subcellular locations; involved in a variety of functions including protein-protein interactions, but common features in the interaction partners have not been defined; involved in chaperone, cell-cycle, transciption, and protein transport complexes; the number of TPR motifs varies among proteins (1,3-11,13 15,16,19); 5-6 tandem repeats generate a right-handed helical structure with an amphipathic channel that is thought to accomodate an alpha-helix of a target protein; it has been proposed that TPR proteins preferably interact with WD-40 repeat proteins, but in many instances several TPR-proteins seem to aggregate to multi-protein complexes; examples of TPR-proteins include, Cdc16p, Cdc23p and Cdc27p components of the cyclosome/APC, the Pex5p/Pas10p receptor for peroxisomal targeting signals, the Tom70p co-receptor for mitochondrial targeting signals, Ser/Thr phosphatase 5C and the p110 subunit of O-GlcNAc transferase; three copies of the repeat are present here | ||
| COG3914 | Spy | 4.0e-88 | 330 | 875 | 575 | + Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0005515 | protein binding |
| GO:0042802 | identical protein binding |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACF96937.1 | 0 | 62 | 881 | 35 | 854 | SPINDLY [Sinningia speciosa] |
| RefSeq | XP_001782948.1 | 0 | 53 | 956 | 1 | 899 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001785267.1 | 0 | 53 | 951 | 1 | 900 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_002308458.1 | 0 | 26 | 938 | 11 | 919 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002530535.1 | 0 | 18 | 885 | 4 | 860 | o-linked n-acetylglucosamine transferase, ogt, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 1w3b_B | 4e-36 | 144 | 435 | 69 | 380 | A Chain A, The Superhelical Tpr Domain Of O-linked Glcnac Transferase Reveals Structural Similarities To Importin Alpha. |
| PDB | 1w3b_B | 1e-26 | 182 | 467 | 66 | 344 | A Chain A, The Superhelical Tpr Domain Of O-linked Glcnac Transferase Reveals Structural Similarities To Importin Alpha. |
| PDB | 1w3b_B | 3e-22 | 243 | 459 | 59 | 302 | A Chain A, The Superhelical Tpr Domain Of O-linked Glcnac Transferase Reveals Structural Similarities To Importin Alpha. |
| PDB | 1w3b_B | 0.000000000003 | 79 | 298 | 174 | 386 | A Chain A, The Superhelical Tpr Domain Of O-linked Glcnac Transferase Reveals Structural Similarities To Importin Alpha. |
| PDB | 1w3b_B | 0.00000000003 | 341 | 464 | 48 | 205 | A Chain A, The Superhelical Tpr Domain Of O-linked Glcnac Transferase Reveals Structural Similarities To Importin Alpha. |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| FC335085 | 279 | 429 | 707 | 0 |
| GO867600 | 327 | 347 | 673 | 0 |
| GO867600 | 142 | 165 | 304 | 0.00000000009 |
| GO867600 | 119 | 79 | 195 | 0.31 |
| FC335085 | 44 | 252 | 295 | 0.32 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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