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Basic Information | |
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Species | Physcomitrella patens |
Cazyme ID | Pp1s48_252V6.1 |
Family | GT47 |
Protein Properties | Length: 478 Molecular Weight: 54956.1 Isoelectric Point: 9.5194 |
Chromosome | Chromosome/Scaffold: 48 Start: 2084976 End: 2087904 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 93 | 389 | 0 |
NLQIYIYDVDEIDGLRELLSGRDHSIASSACVRGQWGTQVKIHKLLMKSRYRTLDKSRANFFFVPVYVKCVRIFGGLNEKEVNEHFLKILRQMPYFHRSG GRDHIFVFPSGAGAHLVKGWPNFLNRSIFLTPEGDRTDKKAFSSFNTWKDIIIPGNVDIINHPSNSATSPLPLSKRKYVANYLGRAQGKKGRLQLIELAK QFPAELDAPELAFQGSAKLGRIEYYNRLRNAKFCLAPRGESSWTLRFYEAFFVECVPVILSDEIELPYQNVLDYSGFSIKWPSSRTNEELLRYLRSI |
Full Sequence |
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Protein Sequence Length: 478 Download |
MQKATMWNGK PRNSSGAGFC RPLEFVVATV LVIITYSCTR FALEVPKQAC RCDLSSRDVL 60 SKESSGCGED HREVNFFWGG FRWPERGYGS RLNLQIYIYD VDEIDGLREL LSGRDHSIAS 120 SACVRGQWGT QVKIHKLLMK SRYRTLDKSR ANFFFVPVYV KCVRIFGGLN EKEVNEHFLK 180 ILRQMPYFHR SGGRDHIFVF PSGAGAHLVK GWPNFLNRSI FLTPEGDRTD KKAFSSFNTW 240 KDIIIPGNVD IINHPSNSAT SPLPLSKRKY VANYLGRAQG KKGRLQLIEL AKQFPAELDA 300 PELAFQGSAK LGRIEYYNRL RNAKFCLAPR GESSWTLRFY EAFFVECVPV ILSDEIELPY 360 QNVLDYSGFS IKWPSSRTNE ELLRYLRSIP EFEIERMLVL GRNIRCLFTY APDSEGCTAM 420 TGILWELQRK VRAFHQYHHT FWLHNASIVN RDLAKFHEWS PPFPVPYSNE LKMTLNN* 480 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 5.0e-42 | 94 | 389 | 309 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAM61682.1 | 0 | 4 | 466 | 2 | 462 | unknown [Arabidopsis thaliana] |
RefSeq | NP_564141.1 | 0 | 4 | 466 | 2 | 462 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_001761473.1 | 0 | 79 | 477 | 1 | 399 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_002300942.1 | 0 | 65 | 466 | 54 | 460 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002307477.1 | 0 | 26 | 466 | 28 | 460 | predicted protein [Populus trichocarpa] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
CX668832 | 291 | 154 | 443 | 0 |
FE707914 | 279 | 134 | 411 | 0 |
FE707913 | 273 | 195 | 466 | 0 |
EH692645 | 267 | 171 | 436 | 0 |
BX841155 | 344 | 1 | 339 | 0 |
Sequence Alignments (This image is cropped. Click for full image.) |
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