Basic Information | |
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Species | Physcomitrella patens |
Cazyme ID | Pp1s53_231V6.1 |
Family | GT47 |
Protein Properties | Length: 421 Molecular Weight: 49190.5 Isoelectric Point: 9.3989 |
Chromosome | Chromosome/Scaffold: 53 Start: 1569991 End: 1572143 |
Description | Exostosin family protein |
View CDS |
External Links |
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NCBI Taxonomy |
Plaza |
CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 95 | 373 | 0 |
EEKFKVYVYPDGDPETYYQTPRKLTGKYSSEGYFFQNLRESRFVTNDSAAADLFFLPVSCHKMRGKGLSYEKMADIVRAYVESLIIKYPFWNRTVGADHF FVTCHDVGVRATAKVEHLVKNSIRVVCSPSYNGSFIPHKDVALPQVLQPFPLPAGGDDIHNRTVLGFWAGHRNSKVRVNLADAWQYDPILFVANNRLNRS TGDYIYQNQFYRSKFCICPAGSQVNSARIAESIHYGCVPEVIMADFYDLPFNDILDWRKFSLVVREREYDNLKKILQAV |
Full Sequence |
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Protein Sequence Length: 421 Download |
MIADSSFSQC WFKYGLMHKC HWRWMWLIVA LLVLAFYYFG VSSSMLLSGV EKDVLAVNLK 60 DGGHSRRTAY SRSREVMEQV YHSTDIFQRS FKEMEEKFKV YVYPDGDPET YYQTPRKLTG 120 KYSSEGYFFQ NLRESRFVTN DSAAADLFFL PVSCHKMRGK GLSYEKMADI VRAYVESLII 180 KYPFWNRTVG ADHFFVTCHD VGVRATAKVE HLVKNSIRVV CSPSYNGSFI PHKDVALPQV 240 LQPFPLPAGG DDIHNRTVLG FWAGHRNSKV RVNLADAWQY DPILFVANNR LNRSTGDYIY 300 QNQFYRSKFC ICPAGSQVNS ARIAESIHYG CVPEVIMADF YDLPFNDILD WRKFSLVVRE 360 REYDNLKKIL QAVTVQKYRM LHAGVRQVRR HFEWHSPPIK YDAFHMVMYE LWLRRFTIRF 420 * |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-53 | 94 | 373 | 299 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_195517.1 | 0 | 20 | 420 | 20 | 425 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_001762181.1 | 0 | 77 | 420 | 1 | 344 | predicted protein [Physcomitrella patens subsp. patens] |
RefSeq | XP_002266299.1 | 0 | 80 | 420 | 77 | 416 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002268836.1 | 0 | 34 | 420 | 33 | 417 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002522880.1 | 0 | 73 | 420 | 60 | 406 | catalytic, putative [Ricinus communis] |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |