| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s61_17V6.2 |
| Family | CE1 |
| Protein Properties | Length: 332 Molecular Weight: 36392 Isoelectric Point: 7.5536 |
| Chromosome | Chromosome/Scaffold: 61 Start: 81415 End: 84100 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CE1 | 72 | 328 | 0 |
| SSSVGCPMTFTIFFPPAADSSKVPVLYWLSGLTCNDENFIQKSGAQRAAAAHGLALVAMDTSPRGLNVEGESDSWDFGTGASFYLNATQEKWKNWRMYDY VTKELPSLLSSHFPQLDTSNASLFGHSMGGHGALTLFLKNPSKYKSVSAFAPICNPTACPWGVKAFNGYLGAEKSAWEEYDATLLVTKYNGPKTTILIDQ GDADKFYKENQLLPENFEQACKSAGMPIDMRIQPGYDHSYFFIASFVEDHIQHHAKA | |||
| Full Sequence |
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| Protein Sequence Length: 332 Download |
| MSLTLGSVVR NASRILGSRV SASSYTFLCR RGSTIVTRAA SEGNQVDNMA TPQEMSSNKV 60 FGGFNRRYKH ESSSVGCPMT FTIFFPPAAD SSKVPVLYWL SGLTCNDENF IQKSGAQRAA 120 AAHGLALVAM DTSPRGLNVE GESDSWDFGT GASFYLNATQ EKWKNWRMYD YVTKELPSLL 180 SSHFPQLDTS NASLFGHSMG GHGALTLFLK NPSKYKSVSA FAPICNPTAC PWGVKAFNGY 240 LGAEKSAWEE YDATLLVTKY NGPKTTILID QGDADKFYKE NQLLPENFEQ ACKSAGMPID 300 MRIQPGYDHS YFFIASFVED HIQHHAKALS V* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK14875 | PRK14875 | 0.002 | 186 | 223 | 38 | + acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional | ||
| pfam00756 | Esterase | 2.0e-49 | 72 | 322 | 263 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 3.0e-80 | 47 | 329 | 312 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 1.0e-123 | 55 | 329 | 276 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 0 | 49 | 331 | 283 | + S-formylglutathione hydrolase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004091 | carboxylesterase activity |
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
| GO:0018738 | S-formylglutathione hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABK22177.1 | 0 | 49 | 329 | 1 | 280 | unknown [Picea sitchensis] |
| GenBank | ACJ84789.1 | 0 | 54 | 331 | 8 | 284 | unknown [Medicago truncatula] |
| RefSeq | NP_001148438.1 | 0 | 50 | 329 | 9 | 287 | esterase D [Zea mays] |
| RefSeq | NP_181684.1 | 0 | 54 | 331 | 7 | 284 | SFGH (S-FORMYLGLUTATHIONE HYDROLASE); S-formylglutathione hydrolase/ hydrolase, acting on ester bonds [Arabidopsis thaliana] |
| RefSeq | XP_001763419.1 | 0 | 55 | 331 | 1 | 277 | predicted protein [Physcomitrella patens subsp. patens] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 53 | 330 | 4 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 53 | 330 | 4 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 53 | 330 | 5 | 279 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 53 | 330 | 5 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 53 | 330 | 5 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| formaldehyde oxidation II (glutathione-dependent) | S-FORMYLGLUTATHIONE-HYDROLASE-RXN | EC-3.1.2.12 | S-formylglutathione hydrolase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| DC943397 | 268 | 19 | 286 | 0 |
| FC370161 | 256 | 1 | 256 | 0 |
| BY993592 | 257 | 1 | 257 | 0 |
| FC443074 | 252 | 19 | 270 | 0 |
| BY950914 | 237 | 1 | 237 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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