| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s61_17V6.5 |
| Family | CE1 |
| Protein Properties | Length: 284 Molecular Weight: 31320.3 Isoelectric Point: 6.5964 |
| Chromosome | Chromosome/Scaffold: 61 Start: 81402 End: 84100 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CE1 | 24 | 280 | 0 |
| SSSVGCPMTFTIFFPPAADSSKVPVLYWLSGLTCNDENFIQKSGAQRAAAAHGLALVAMDTSPRGLNVEGESDSWDFGTGASFYLNATQEKWKNWRMYDY VTKELPSLLSSHFPQLDTSNASLFGHSMGGHGALTLFLKNPSKYKSVSAFAPICNPTACPWGVKAFNGYLGAEKSAWEEYDATLLVTKYNGPKTTILIDQ GDADKFYKENQLLPENFEQACKSAGMPIDMRIQPGYDHSYFFIASFVEDHIQHHAKA | |||
| Full Sequence |
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| Protein Sequence Length: 284 Download |
| MATPQEMSSN KVFGGFNRRY KHESSSVGCP MTFTIFFPPA ADSSKVPVLY WLSGLTCNDE 60 NFIQKSGAQR AAAAHGLALV AMDTSPRGLN VEGESDSWDF GTGASFYLNA TQEKWKNWRM 120 YDYVTKELPS LLSSHFPQLD TSNASLFGHS MGGHGALTLF LKNPSKYKSV SAFAPICNPT 180 ACPWGVKAFN GYLGAEKSAW EEYDATLLVT KYNGPKTTIL IDQGDADKFY KENQLLPENF 240 EQACKSAGMP IDMRIQPGYD HSYFFIASFV EDHIQHHAKA LSV* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK14875 | PRK14875 | 0.001 | 138 | 175 | 38 | + acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional | ||
| pfam00756 | Esterase | 2.0e-49 | 24 | 274 | 263 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 5.0e-80 | 7 | 281 | 304 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 3.0e-123 | 7 | 281 | 276 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 0 | 1 | 283 | 283 | + S-formylglutathione hydrolase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004091 | carboxylesterase activity |
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
| GO:0018738 | S-formylglutathione hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABK22177.1 | 0 | 1 | 281 | 1 | 280 | unknown [Picea sitchensis] |
| RefSeq | NP_001148438.1 | 0 | 2 | 281 | 9 | 287 | esterase D [Zea mays] |
| RefSeq | NP_181684.1 | 0 | 6 | 283 | 7 | 284 | SFGH (S-FORMYLGLUTATHIONE HYDROLASE); S-formylglutathione hydrolase/ hydrolase, acting on ester bonds [Arabidopsis thaliana] |
| RefSeq | XP_001763419.1 | 0 | 7 | 283 | 1 | 277 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_002456916.1 | 0 | 2 | 281 | 3 | 281 | hypothetical protein SORBIDRAFT_03g045400 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 5 | 282 | 4 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 5 | 282 | 4 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 5 | 282 | 5 | 279 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 5 | 282 | 5 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 5 | 282 | 5 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| formaldehyde oxidation II (glutathione-dependent) | S-FORMYLGLUTATHIONE-HYDROLASE-RXN | EC-3.1.2.12 | S-formylglutathione hydrolase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| DC943397 | 238 | 1 | 238 | 0 |
| FC443074 | 222 | 1 | 222 | 0 |
| BJ954751 | 203 | 82 | 284 | 0 |
| FC443073 | 203 | 82 | 284 | 0 |
| HO352974 | 281 | 1 | 281 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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