| Basic Information | |
|---|---|
| Species | Physcomitrella patens |
| Cazyme ID | Pp1s7_425V6.1 |
| Family | GT47 |
| Protein Properties | Length: 472 Molecular Weight: 53595 Isoelectric Point: 6.5531 |
| Chromosome | Chromosome/Scaffold: 7 Start: 2601746 End: 2603161 |
| Description | Exostosin family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GT47 | 131 | 412 | 0 |
| QLQIWVYPTQAGSTKYEHNYDGDEDVTEEISSTADLFFRLLTRSEFVTEKAKRAQLFLLPFSIDVLWVDLGPTQVAEKLRRYLEKVRTNYPYWESSLGAD HFYLSCHAFEHNSKHRNILELGKNSIQAACAPLRHNQKFYPHKDVVFPQYKPVGEEDVRQAILGRRNRTSLAYFSGCPDVTTPLLSAFHTWETDPDFIVE ANPSPHRLSVYRNLARSRFCVSVLPHDTFSLVDALRFGCVPVLLSKLTFHDLPFQGFLNWGQFAVVLGIEDLPNLKQILANV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 472 Download |
| MGLISREISV PTVVVSYLTL LLAYGFLLTA ITCSRAPREL SVNQSPPTVI SQISNNDSSK 60 LALAHGRSLL SLESEDKLEG MPKVGVEVSI SDPVSALDIS ELDLIALHES LPKLYHSPKV 120 FTLSYEEMRE QLQIWVYPTQ AGSTKYEHNY DGDEDVTEEI SSTADLFFRL LTRSEFVTEK 180 AKRAQLFLLP FSIDVLWVDL GPTQVAEKLR RYLEKVRTNY PYWESSLGAD HFYLSCHAFE 240 HNSKHRNILE LGKNSIQAAC APLRHNQKFY PHKDVVFPQY KPVGEEDVRQ AILGRRNRTS 300 LAYFSGCPDV TTPLLSAFHT WETDPDFIVE ANPSPHRLSV YRNLARSRFC VSVLPHDTFS 360 LVDALRFGCV PVLLSKLTFH DLPFQGFLNW GQFAVVLGIE DLPNLKQILA NVSSTKHREM 420 QYLGHQAIKH LEWNNPPVAY DAFHMTLLEL WVRRHSIKYT RQVEASSFDD S* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 2.0e-37 | 128 | 412 | 301 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACU18220.1 | 0 | 111 | 459 | 67 | 409 | unknown [Glycine max] |
| RefSeq | NP_195517.1 | 0 | 109 | 459 | 81 | 425 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_001753053.1 | 0 | 1 | 471 | 1 | 471 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001774055.1 | 0 | 51 | 395 | 66 | 410 | predicted protein [Physcomitrella patens subsp. patens] |
| RefSeq | XP_001774096.1 | 0 | 112 | 459 | 1 | 351 | predicted protein [Physcomitrella patens subsp. patens] |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |
