| Basic Information | |
|---|---|
| Species | Sorghum bicolor |
| Cazyme ID | Sb01g034960.1 |
| Family | GH89 |
| Protein Properties | Length: 778 Molecular Weight: 87569.9 Isoelectric Point: 7.3586 |
| Chromosome | Chromosome/Scaffold: 1 Start: 58424904 End: 58434848 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 106 | 773 | 0 |
| AEILIQGTTGVELASGLHWYLKYWCGAHISWDRTGGAQLASIPSPGSLPRVQGKGVKIERPVLWNYYQNVVTSSYSYVWWDWKRWEKEIDWMALQGINLP LAFTGQESIWQKVFKSFNVTDRDLDDFFGGPAFLAWARMGNLHGWGGPLSQNWLDQQLALQKKVLSRMIELGMVPVLPSFSGNVPAVFAKLFPSANITLL GDWNTVDANPKWCCTYLLDPSDSLFIDVGQAFIRQQIKEYGDVTNIYNCDTFNENTPPTDEPAYISSLGSAIYEAMSRGNKNAVWLMQGWLFYSDAAFWK EPQMKALLHSVPIGKMIVLDLFADVKPIWKMSSQFYGVPYIWCMLHNFGGNIEMYGVLDSISSGPIDARTSYNSTMIGVGMCMEGIEHNPVVYELMSEMA FHNKKVEVEDHNKDYIVEFPDISPSSISSQLSKRRGMSIMRNHRRFFLSEVSGSLPHPHLWYSTKEAIKALELFLDAGSTFSKSLTYRYDLVDLTRQCLS KLANEVYLDAMSSYQKKDSNGLNSHTRKFLEIIMDIDTLLAADDNFLLGPWLESAKSLAITEKERQQYEWNARTQVTMWYDNTETEQSKLHDYANKFWSG LLKSYYLPRASKYFAYLTRSLQENQSFQLEEWRKDWISYSNEWQSGKEVYAVKATGDALAIARSLYRK | |||
| Full Sequence |
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| Protein Sequence Length: 778 Download |
| MRLSPPRRLL PLAPFLLLLL TLLSPPRAAA AAGGGPSAWV ALRGAAGSRK ASPAEQEAAA 60 AGLLRRLLPS HAGSFSFQID SKGAVCGQSS CFRISNVVDG SGKGGAEILI QGTTGVELAS 120 GLHWYLKYWC GAHISWDRTG GAQLASIPSP GSLPRVQGKG VKIERPVLWN YYQNVVTSSY 180 SYVWWDWKRW EKEIDWMALQ GINLPLAFTG QESIWQKVFK SFNVTDRDLD DFFGGPAFLA 240 WARMGNLHGW GGPLSQNWLD QQLALQKKVL SRMIELGMVP VLPSFSGNVP AVFAKLFPSA 300 NITLLGDWNT VDANPKWCCT YLLDPSDSLF IDVGQAFIRQ QIKEYGDVTN IYNCDTFNEN 360 TPPTDEPAYI SSLGSAIYEA MSRGNKNAVW LMQGWLFYSD AAFWKEPQMK ALLHSVPIGK 420 MIVLDLFADV KPIWKMSSQF YGVPYIWCML HNFGGNIEMY GVLDSISSGP IDARTSYNST 480 MIGVGMCMEG IEHNPVVYEL MSEMAFHNKK VEVEDHNKDY IVEFPDISPS SISSQLSKRR 540 GMSIMRNHRR FFLSEVSGSL PHPHLWYSTK EAIKALELFL DAGSTFSKSL TYRYDLVDLT 600 RQCLSKLANE VYLDAMSSYQ KKDSNGLNSH TRKFLEIIMD IDTLLAADDN FLLGPWLESA 660 KSLAITEKER QQYEWNARTQ VTMWYDNTET EQSKLHDYAN KFWSGLLKSY YLPRASKYFA 720 YLTRSLQENQ SFQLEEWRKD WISYSNEWQS GKEVYAVKAT GDALAIARSL YRKYLSS* 780 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 3.0e-17 | 71 | 156 | 86 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 1.0e-83 | 540 | 774 | 235 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 171 | 507 | 337 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 12 | 776 | 66 | 868 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 51 | 775 | 51 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| GenBank | EEE59081.1 | 0 | 51 | 776 | 51 | 812 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | XP_002314048.1 | 0 | 29 | 775 | 19 | 805 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002465249.1 | 0 | 1 | 777 | 1 | 777 | hypothetical protein SORBIDRAFT_01g034960 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 95 | 765 | 201 | 867 | A Chain A, Crystal Structure Of Galactosyltransferase Lgtc In Complex With Mn And Udp-2f-Galactose |
| PDB | 2vcb_A | 0 | 95 | 765 | 201 | 867 | A Chain A, Crystal Structure Of Galactosyltransferase Lgtc In Complex With Mn And Udp-2f-Galactose |
| PDB | 2vca_A | 0 | 95 | 765 | 201 | 867 | A Chain A, Crystal Structure Of Galactosyltransferase Lgtc In Complex With Mn And Udp-2f-Galactose |
| PDB | 2vc9_A | 0 | 95 | 765 | 201 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 95 | 765 | 224 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
