| Basic Information | |
|---|---|
| Species | Sorghum bicolor |
| Cazyme ID | Sb03g045400.1 |
| Family | CE1 |
| Protein Properties | Length: 285 Molecular Weight: 31621.8 Isoelectric Point: 6.7855 |
| Chromosome | Chromosome/Scaffold: 3 Start: 72653160 End: 72659117 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
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| Family | Start | End | Evalue |
| CE1 | 25 | 278 | 0 |
| SATLGCAMTFSIYMPPSPASNIPVLYWLSGLTCTDENFIMKSGAQRAAAAHGIALVSPDTSPRGLNIEGESDSYDFGVGAGFYLNATNEKWKNWRMYDYV VKELPKVLSDNFEQLNTSQASIFGHSMGGHGALTIYLKNTDKYKSVSAFAPIANPINCPWGQKAFSNYLGPTKSDWEEYDATCLIKKNSNVPTPILIDQG DADKFLAEQQLLPHNFEEACKAVGATLILRMQPRYDHSYYFIATFMDDHIAHHA | |||
| Full Sequence |
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| Protein Sequence Length: 285 Download |
| MAAALEQLSR SKMFDGFNLR FRHQSATLGC AMTFSIYMPP SPASNIPVLY WLSGLTCTDE 60 NFIMKSGAQR AAAAHGIALV SPDTSPRGLN IEGESDSYDF GVGAGFYLNA TNEKWKNWRM 120 YDYVVKELPK VLSDNFEQLN TSQASIFGHS MGGHGALTIY LKNTDKYKSV SAFAPIANPI 180 NCPWGQKAFS NYLGPTKSDW EEYDATCLIK KNSNVPTPIL IDQGDADKFL AEQQLLPHNF 240 EEACKAVGAT LILRMQPRYD HSYYFIATFM DDHIAHHAKF LKSA* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| COG1506 | DAP2 | 0.008 | 138 | 277 | 162 | + Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism] | ||
| pfam00756 | Esterase | 1.0e-45 | 25 | 276 | 265 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 3.0e-84 | 1 | 284 | 314 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 3.0e-125 | 6 | 281 | 278 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 0 | 1 | 283 | 284 | + S-formylglutathione hydrolase | ||
| Annotations - NR Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_001045351.1 | 0 | 5 | 284 | 14 | 292 | Os01g0939700 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001148438.1 | 0 | 2 | 284 | 8 | 290 | esterase D [Zea mays] |
| RefSeq | NP_181684.1 | 0 | 1 | 282 | 1 | 283 | SFGH (S-FORMYLGLUTATHIONE HYDROLASE); S-formylglutathione hydrolase/ hydrolase, acting on ester bonds [Arabidopsis thaliana] |
| RefSeq | XP_002284489.1 | 0 | 1 | 281 | 1 | 282 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
| RefSeq | XP_002456916.1 | 0 | 1 | 284 | 1 | 284 | hypothetical protein SORBIDRAFT_03g045400 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
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| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 4 | 283 | 2 | 282 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 4 | 283 | 2 | 282 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 4 | 283 | 3 | 280 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 4 | 283 | 3 | 280 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 4 | 283 | 3 | 280 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Metabolic Pathways | |||
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| Pathway Name | Reaction | EC | Protein Name |
| formaldehyde oxidation II (glutathione-dependent) | S-FORMYLGLUTATHIONE-HYDROLASE-RXN | EC-3.1.2.12 | S-formylglutathione hydrolase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| CO446000 | 267 | 10 | 276 | 0 |
| DR824616 | 264 | 2 | 265 | 0 |
| EG384989 | 284 | 2 | 285 | 0 |
| DR814824 | 253 | 2 | 254 | 0 |
| CT848008 | 281 | 5 | 285 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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