| Basic Information | |
|---|---|
| Species | Sorghum bicolor |
| Cazyme ID | Sb04g008542.1 |
| Family | AA7 |
| Protein Properties | Length: 548 Molecular Weight: 59057.3 Isoelectric Point: 8.7203 |
| Chromosome | Chromosome/Scaffold: 4 Start: 9913557 End: 9915200 |
| Description | FAD-binding Berberine family protein |
| View CDS | |
| External Links |
|---|
| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA7 | 84 | 547 | 0 |
| PRTPRPALLLTPATVAEVRACVACCRRQGLTVRARSGGHDYEGLSYRSVLQSAGTARPFAVVDVAALRDVRVDAARRVATVGPGATLGELYYAVARDSGG ALGFPAGICPTVCVGGHLSGGGFGPMMRKHGLGADNVVDAEVVDADGRLLDRAAMGEGHFWAIRGGGGGSFGVVVSWTVRLVPVPRVVSAFTVRRLVRRG DRRQTQATVRLLAKWQRVAHALPDDLFVKAAMEPELDDAGERHPLVTFKSLFLGGNCSGMVAEMSAHLPELGVTASDCRDMSWIQSMLYFYGYTSGQTAA EVLLDRSLQPKDYYKVKLDYVTTPIPAAGLAGLLARVVEDRGGSIDVDPQGGAMSATPESDTPYAHRRGYLYNVQYFVKWGGDANVSYEDAHLGWVRGVH RWMTPYASASPRAAYVNFRDLDLGQNVDGKTTYEAARAWGEMYFRGNFRRLAMVKAEVDPDQVF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 548 Download |
| MAVVRPRSAA HLSLLFLLLL APPCSPQEQD DGGGGVALHG SFVRCVARLS PATTDPSRLV 60 HAPSAASYTS LLNATIQNLR FASPRTPRPA LLLTPATVAE VRACVACCRR QGLTVRARSG 120 GHDYEGLSYR SVLQSAGTAR PFAVVDVAAL RDVRVDAARR VATVGPGATL GELYYAVARD 180 SGGALGFPAG ICPTVCVGGH LSGGGFGPMM RKHGLGADNV VDAEVVDADG RLLDRAAMGE 240 GHFWAIRGGG GGSFGVVVSW TVRLVPVPRV VSAFTVRRLV RRGDRRQTQA TVRLLAKWQR 300 VAHALPDDLF VKAAMEPELD DAGERHPLVT FKSLFLGGNC SGMVAEMSAH LPELGVTASD 360 CRDMSWIQSM LYFYGYTSGQ TAAEVLLDRS LQPKDYYKVK LDYVTTPIPA AGLAGLLARV 420 VEDRGGSIDV DPQGGAMSAT PESDTPYAHR RGYLYNVQYF VKWGGDANVS YEDAHLGWVR 480 GVHRWMTPYA SASPRAAYVN FRDLDLGQNV DGKTTYEAAR AWGEMYFRGN FRRLAMVKAE 540 VDPDQVFW 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| COG0277 | GlcD | 0.0002 | 98 | 271 | 182 | + FAD/FMN-containing dehydrogenases [Energy production and conversion] | ||
| pfam08031 | BBE | 3.0e-12 | 497 | 548 | 52 | + Berberine and berberine like. This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine. | ||
| pfam01565 | FAD_binding_4 | 5.0e-13 | 98 | 234 | 137 | + FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACL54298.1 | 0 | 2 | 548 | 7 | 469 | unknown [Zea mays] |
| GenBank | ACN34780.1 | 0 | 2 | 548 | 7 | 543 | unknown [Zea mays] |
| GenBank | EAY85134.1 | 0 | 1 | 548 | 1 | 545 | hypothetical protein OsI_06489 [Oryza sativa Indica Group] |
| RefSeq | NP_001046387.1 | 0 | 19 | 548 | 20 | 546 | Os02g0235900 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002451843.1 | 0 | 1 | 548 | 1 | 548 | hypothetical protein SORBIDRAFT_04g008542 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4dns_B | 0 | 22 | 547 | 3 | 487 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 4dns_A | 0 | 22 | 547 | 3 | 487 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 3vte_A | 0 | 41 | 547 | 6 | 504 | A Chain A, Crystal Structure Of Tetrahydrocannabinolic Acid Synthase From Cannabis Sativa |
| PDB | 3tsj_B | 0 | 56 | 547 | 20 | 487 | A Chain A, Crystal Structure Of Tetrahydrocannabinolic Acid Synthase From Cannabis Sativa |
| PDB | 3tsj_A | 0 | 56 | 547 | 20 | 487 | A Chain A, Crystal Structure Of Tetrahydrocannabinolic Acid Synthase From Cannabis Sativa |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cannabinoid biosynthesis | RXN-7854 | EC-1.21.3 | tetrahydrocannabinolic acid synthase |
