| Basic Information | |
|---|---|
| Species | Sorghum bicolor |
| Cazyme ID | Sb04g036200.1 |
| Family | GH79 |
| Protein Properties | Length: 541 Molecular Weight: 58610.3 Isoelectric Point: 6.1832 |
| Chromosome | Chromosome/Scaffold: 4 Start: 65989342 End: 65992867 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 51 | 534 | 0 |
| DDDFVCATLDWWPPEKCDYGTCSWGLDSLLNLNLSNKILMNAVKAFSPLKLRLGGTLQDMVIYDTGDSRQPCTPFVKNTSAMFGFSQGCLPLHRWDELNA FFQKTGPKVIFGLNALTGRVPMPDGSLGGPWNYTNAASFIRYTVNKGYDIHGWELGNELSGSGVGARIDADQYAADVITLKHIIDSTYQSNPSKPLVIAP GGFFDAAWFTELISKTKPNQMNAITHHIYNLGPGVDDHLVQKILDPSYLDGEASTFSNLQGILKSAGTSTVAWVGEAGGAYNSGHHLVTDAFVFSFWYLD QLGMASKYDTKTYCRQTFVGGNYGLLNTTTFEPNPDYYSALLWHRLMGTKVLSTTFNGTNKIRAYAHCAKNSEGITLLLINLDGNNTNHICVTSQGAQTQ SARKESRMSYQIPGLGEAAELTRQEYHLTPKGGNLQSQQMLLNGNVLATDANGDIPKLEPVQVEGTQPITVGPYSIVFAHIPSF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 541 Download |
| MAAGLLLKMV GFCVWALFWL AGSATVSTST TAFAGSEAVV VDARSAIAVT DDDFVCATLD 60 WWPPEKCDYG TCSWGLDSLL NLNLSNKILM NAVKAFSPLK LRLGGTLQDM VIYDTGDSRQ 120 PCTPFVKNTS AMFGFSQGCL PLHRWDELNA FFQKTGPKVI FGLNALTGRV PMPDGSLGGP 180 WNYTNAASFI RYTVNKGYDI HGWELGNELS GSGVGARIDA DQYAADVITL KHIIDSTYQS 240 NPSKPLVIAP GGFFDAAWFT ELISKTKPNQ MNAITHHIYN LGPGVDDHLV QKILDPSYLD 300 GEASTFSNLQ GILKSAGTST VAWVGEAGGA YNSGHHLVTD AFVFSFWYLD QLGMASKYDT 360 KTYCRQTFVG GNYGLLNTTT FEPNPDYYSA LLWHRLMGTK VLSTTFNGTN KIRAYAHCAK 420 NSEGITLLLI NLDGNNTNHI CVTSQGAQTQ SARKESRMSY QIPGLGEAAE LTRQEYHLTP 480 KGGNLQSQQM LLNGNVLATD ANGDIPKLEP VQVEGTQPIT VGPYSIVFAH IPSFYAPACS 540 * |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 38 | 353 | 316 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACR36272.1 | 0 | 1 | 457 | 1 | 458 | unknown [Zea mays] |
| GenBank | EAY87898.1 | 0 | 1 | 539 | 1 | 540 | hypothetical protein OsI_09318 [Oryza sativa Indica Group] |
| GenBank | EAY99897.1 | 0 | 11 | 540 | 9 | 525 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| RefSeq | NP_001048420.1 | 0 | 1 | 539 | 1 | 540 | Os02g0802200 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002452991.1 | 0 | 1 | 540 | 1 | 540 | hypothetical protein SORBIDRAFT_04g036200 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.000005 | 146 | 435 | 122 | 403 | A Chain A, Insight Into The Mechanism Of Enzymatic Glycosyltransfer With Retention Through The Synthesis And Analysis Of Bisubstrate Glycomimetics Of Trehalose-6-Phosphate Synthase |
| PDB | 3vnz_A | 0.000005 | 146 | 435 | 122 | 403 | A Chain A, Insight Into The Mechanism Of Enzymatic Glycosyltransfer With Retention Through The Synthesis And Analysis Of Bisubstrate Glycomimetics Of Trehalose-6-Phosphate Synthase |
| PDB | 3vny_A | 0.000005 | 146 | 435 | 122 | 403 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
