| Basic Information | |
|---|---|
| Species | Sorghum bicolor |
| Cazyme ID | Sb06g025960.1 |
| Family | AA3 |
| Protein Properties | Length: 596 Molecular Weight: 64202.4 Isoelectric Point: 5.7724 |
| Chromosome | Chromosome/Scaffold: 6 Start: 55039899 End: 55042208 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 46 | 586 | 0 |
| PSVSYYDYIIVGGGTAGCPLAATLSERFRVLLLERGGSPYDDERIGDMTRFADTLSDTSPGSPAQRFVSEDGVINSRPRVLGGGSCINAGFYTRASDDYV RDAGWDLGATGAAYRWVEDVVAFQPELGPWQAAFQSGLLEAGVAPDNGFTFDHLDGTKVGGSIFDADGRRHTAADLLRYARAEGLDVLLRARVAKILFVN VRAGRRPVARGVVFHDSEGRMHKAYLNAGRRNEIILSAGAMGSPQLLMLSGVGPADHLSSFGITLVHDQPAVGQGMSDNPMNAIYVPSPSPVEVSLIQVV GITQVGSYIEGASGSNWGVPQSASGGGVDRPRNFGMFSPQTGQLATVPPKQRTPEAIERAAESMRQLDDSAFRGGFILEKVLGPLSTGHLELRSRDPDDN PSVTFNYFSHPEDLRRCVAGLSVIESVIHSKAFENFTYSYFSMETLLNMSTGFPVNLLPRHDSDSTSLEMFCKDTVMTIWHYHGGCQVGRVVDAEYRVLG VDALRVIDGSTFNASPGTNPQATVMMLGRYMGVRIQNERLK | |||
| Full Sequence |
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| Protein Sequence Length: 596 Download |
| MAADDLHFTR TLSTVLATSF FVLLCSSLQA VRGVNYTFVK DAALAPSVSY YDYIIVGGGT 60 AGCPLAATLS ERFRVLLLER GGSPYDDERI GDMTRFADTL SDTSPGSPAQ RFVSEDGVIN 120 SRPRVLGGGS CINAGFYTRA SDDYVRDAGW DLGATGAAYR WVEDVVAFQP ELGPWQAAFQ 180 SGLLEAGVAP DNGFTFDHLD GTKVGGSIFD ADGRRHTAAD LLRYARAEGL DVLLRARVAK 240 ILFVNVRAGR RPVARGVVFH DSEGRMHKAY LNAGRRNEII LSAGAMGSPQ LLMLSGVGPA 300 DHLSSFGITL VHDQPAVGQG MSDNPMNAIY VPSPSPVEVS LIQVVGITQV GSYIEGASGS 360 NWGVPQSASG GGVDRPRNFG MFSPQTGQLA TVPPKQRTPE AIERAAESMR QLDDSAFRGG 420 FILEKVLGPL STGHLELRSR DPDDNPSVTF NYFSHPEDLR RCVAGLSVIE SVIHSKAFEN 480 FTYSYFSMET LLNMSTGFPV NLLPRHDSDS TSLEMFCKDT VMTIWHYHGG CQVGRVVDAE 540 YRVLGVDALR VIDGSTFNAS PGTNPQATVM MLGRYMGVRI QNERLKAEGV EGTKL* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK02106 | PRK02106 | 8.0e-16 | 429 | 573 | 151 | + choline dehydrogenase; Validated | ||
| PRK02106 | PRK02106 | 6.0e-32 | 51 | 323 | 318 | + choline dehydrogenase; Validated | ||
| TIGR01810 | betA | 7.0e-40 | 52 | 573 | 580 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 9.0e-50 | 51 | 584 | 593 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PLN02785 | PLN02785 | 0 | 20 | 590 | 588 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAD29242.1 | 0 | 12 | 589 | 1 | 617 | putative mandelonitrile lyase [Oryza sativa Japonica Group] |
| GenBank | EAY87068.1 | 0 | 12 | 589 | 1 | 578 | hypothetical protein OsI_08464 [Oryza sativa Indica Group] |
| RefSeq | NP_001053612.1 | 0 | 3 | 590 | 2 | 586 | Os04g0573100 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001146691.1 | 0 | 1 | 594 | 1 | 598 | hypothetical protein LOC100280292 [Zea mays] |
| RefSeq | XP_002446965.1 | 0 | 1 | 595 | 1 | 595 | hypothetical protein SORBIDRAFT_06g025960 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3gdp_B | 0 | 37 | 584 | 13 | 517 | A Chain A, Structural Insights Into The Processivity Of Endopolygalacturonase I From Aspergillus Niger |
| PDB | 3gdp_A | 0 | 37 | 584 | 13 | 517 | A Chain A, Structural Insights Into The Processivity Of Endopolygalacturonase I From Aspergillus Niger |
| PDB | 3gdn_B | 0 | 37 | 584 | 13 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 3gdn_A | 0 | 37 | 584 | 13 | 517 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| PDB | 1ju2_B | 0 | 37 | 584 | 13 | 517 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cutin biosynthesis | RXN-2121 | EC-1.1.1 | 18-hydroxyoleate dehydrogenase |
| cutin biosynthesis | RXN-9802 | EC-1.1.1 | 16-hydroxypalmitate dehydrogenase |
| suberin biosynthesis | RXN-2121 | EC-1.1.1 | 18-hydroxyoleate dehydrogenase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| HO796743 | 534 | 52 | 584 | 0 |
| FL792146 | 257 | 310 | 566 | 0 |
| EE022597 | 273 | 1 | 269 | 0 |
| EC884792 | 246 | 1 | 245 | 0 |
| EE021109 | 246 | 1 | 245 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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