| Basic Information | |
|---|---|
| Species | Sorghum bicolor |
| Cazyme ID | Sb06g026860.1 |
| Family | GT4 |
| Protein Properties | Length: 419 Molecular Weight: 46364.7 Isoelectric Point: 7.0925 |
| Chromosome | Chromosome/Scaffold: 6 Start: 55870177 End: 55873152 |
| Description | UDP-Glycosyltransferase superfamily protein |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT4 | 223 | 384 | 7.6e-39 |
| FLSINRFERKKNLDLAISAFALLRSVASTLPGDALQEATLTVAGGYDKRLKENVEYLEELKRLAVTEGVSGQVNFVTSCSTSERNELLSNCLCVLYTPKD EHFGIVPLEAMAAYKPVIACNSGGPVETVVNEVTGFLCDPSPTEFSKAMLKLVNDHDLAVRL | |||
| Full Sequence |
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| Protein Sequence Length: 419 Download |
| MAAAGGEVAG ASSGTRTKRL KIAVIHPDLG IGGAERLIVD AACQLAAHGH DVHVFTSHHD 60 KNRCFEETVS GLFPVTVYGD FLPRHVFYRF HAVCAYLRCI FVALCVLLRW PFFDVILVDQ 120 VSVVIPLLKL RASSKIIFYC HFPDLLLAQH TTMLRKLYRK PIDMIEEITT GMADLILVNS 180 KFTAATFART FSCLHARGIE PGVLYPAVSV EQFHEPHAYK LNFLSINRFE RKKNLDLAIS 240 AFALLRSVAS TLPGDALQEA TLTVAGGYDK RLKENVEYLE ELKRLAVTEG VSGQVNFVTS 300 CSTSERNELL SNCLCVLYTP KDEHFGIVPL EAMAAYKPVI ACNSGGPVET VVNEVTGFLC 360 DPSPTEFSKA MLKLVNDHDL AVRLGEQARD HVVQKFSTKT FGDLLNGYVL NVYHERME* 420 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd03798 | GT1_wlbH_like | 1.0e-33 | 22 | 397 | 398 | + This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS. | ||
| cd03811 | GT1_WabH_like | 2.0e-34 | 21 | 397 | 391 | + This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core. | ||
| COG0438 | RfaG | 2.0e-36 | 18 | 418 | 405 | + Glycosyltransferase [Cell envelope biogenesis, outer membrane] | ||
| cd03801 | GT1_YqgM_like | 2.0e-47 | 21 | 397 | 392 | + This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. | ||
| cd03805 | GT1_ALG2_like | 0 | 20 | 403 | 397 | + This family is most closely related to the GT1 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0009058 | biosynthetic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | EAY95346.1 | 0 | 13 | 418 | 13 | 418 | hypothetical protein OsI_17177 [Oryza sativa Indica Group] |
| RefSeq | NP_001053699.1 | 0 | 13 | 418 | 13 | 418 | Os04g0589600 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002317454.1 | 0 | 18 | 412 | 3 | 407 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002447012.1 | 0 | 1 | 418 | 1 | 418 | hypothetical protein SORBIDRAFT_06g026860 [Sorghum bicolor] |
| RefSeq | XP_002525620.1 | 0 | 16 | 412 | 5 | 402 | alpha-1,3-mannosyltransferase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2f9f_A | 6e-18 | 223 | 379 | 26 | 164 | A Chain A, Crystal Structure Of The Putative Mannosyl Transferase (Wbaz-1)from Archaeoglobus Fulgidus, Northeast Structural Genomics Target Gr29a |
| PDB | 2jjm_L | 0.0000002 | 308 | 399 | 280 | 372 | A Chain A, Crystal Structure Of A Family Gt4 Glycosyltransferase From Bacillus Anthracis Orf Ba1558. |
| PDB | 2jjm_K | 0.0000002 | 308 | 399 | 280 | 372 | A Chain A, Crystal Structure Of A Family Gt4 Glycosyltransferase From Bacillus Anthracis Orf Ba1558. |
| PDB | 2jjm_J | 0.0000002 | 308 | 399 | 280 | 372 | A Chain A, Crystal Structure Of A Family Gt4 Glycosyltransferase From Bacillus Anthracis Orf Ba1558. |
| PDB | 2jjm_I | 0.0000002 | 308 | 399 | 280 | 372 | A Chain A, Crystal Structure Of A Family Gt4 Glycosyltransferase From Bacillus Anthracis Orf Ba1558. |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| dolichyl-diphosphooligosaccharide biosynthesis | RXN-5462 | EC-2.4.1.132 | GDP-Man:Man1GlcNAc2-PP-Dol α-1,3-mannosyltransferase |
| dolichyl-diphosphooligosaccharide biosynthesis | RXN-5463 | EC-2.4.1.257 | GDP-Man:Man2GlcNAc2-PP-Dol α-1,6-mannosyltransferase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| GO874725 | 340 | 15 | 351 | 0 |
| CN129110 | 268 | 15 | 282 | 0 |
| GO851037 | 295 | 15 | 309 | 0 |
| CN149614 | 242 | 15 | 256 | 0 |
| GO848903 | 316 | 15 | 330 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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