| Basic Information | |
|---|---|
| Species | Sorghum bicolor |
| Cazyme ID | Sb10g005260.1 |
| Family | GH79 |
| Protein Properties | Length: 555 Molecular Weight: 59363.9 Isoelectric Point: 9.8175 |
| Chromosome | Chromosome/Scaffold: 10 Start: 4703039 End: 4706124 |
| Description | glucuronidase 3 |
| View CDS | |
| External Links |
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| NCBI Taxonomy |
| Plaza |
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 49 | 548 | 0 |
| EDFVCATLDWWPPDKCDYGTCAWGRAGLLNLDLSNKVLLNAVRAFSPPLVLRLGGSLQNKVVYGTADLGGRPCAPFAKNASEMHGFTQGCLPLRRWDELN AFFQKSGAKIVFGLNALNGRVPLPDKSMGGPWDYTNAAALIRYSVNKGYRIHGWELGNELSGTGVGTRVGAEQYATDVIALKKLVDDIYRSNQTKPLVLA PGGFFDQAWFSQLIAKTKPNLLNVITHHIYNLGPGKDTHLIDKIFNPSILDGMKGTFSSLQGMLKSAGTSTVAWVGEAGGAYNSGRHLVTDAFVFSFWFL DQLGMSAKYDTKSYCRQSLIGGNYGLLNTTTFQPNPDYYSALLWHRLMGTKVLATTFNGTNKIRAYAHCARDSPGITLLLINLSGNTTTQVSVTVTTQGQ GAVAAHKHGARKHVGGRKFGHVHGPRFTGVDEAAAGAVRDEYHLTPKDGNLRSQVMLLNGKALATDAAGNIPALEAVKVDAAQPIAVAPYSIVFARISHF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 555 Download |
| MAAAGTRQQL GRLLGGLWFL LAALSLRAAA GQPAVATVDA RRAVAATGED FVCATLDWWP 60 PDKCDYGTCA WGRAGLLNLD LSNKVLLNAV RAFSPPLVLR LGGSLQNKVV YGTADLGGRP 120 CAPFAKNASE MHGFTQGCLP LRRWDELNAF FQKSGAKIVF GLNALNGRVP LPDKSMGGPW 180 DYTNAAALIR YSVNKGYRIH GWELGNELSG TGVGTRVGAE QYATDVIALK KLVDDIYRSN 240 QTKPLVLAPG GFFDQAWFSQ LIAKTKPNLL NVITHHIYNL GPGKDTHLID KIFNPSILDG 300 MKGTFSSLQG MLKSAGTSTV AWVGEAGGAY NSGRHLVTDA FVFSFWFLDQ LGMSAKYDTK 360 SYCRQSLIGG NYGLLNTTTF QPNPDYYSAL LWHRLMGTKV LATTFNGTNK IRAYAHCARD 420 SPGITLLLIN LSGNTTTQVS VTVTTQGQGA VAAHKHGARK HVGGRKFGHV HGPRFTGVDE 480 AAAGAVRDEY HLTPKDGNLR SQVMLLNGKA LATDAAGNIP ALEAVKVDAA QPIAVAPYSI 540 VFARISHFNA PACS* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 2.0e-179 | 49 | 352 | 304 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACF81144.1 | 0 | 1 | 554 | 1 | 543 | unknown [Zea mays] |
| GenBank | EAY99897.1 | 0 | 8 | 554 | 1 | 525 | hypothetical protein OsI_21892 [Oryza sativa Indica Group] |
| RefSeq | NP_001132339.1 | 0 | 1 | 554 | 1 | 543 | hypothetical protein LOC100193781 [Zea mays] |
| RefSeq | NP_001152083.1 | 0 | 1 | 553 | 1 | 548 | heparanase-like protein 3 [Zea mays] |
| RefSeq | XP_002437942.1 | 0 | 1 | 554 | 1 | 554 | hypothetical protein SORBIDRAFT_10g005260 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.00005 | 60 | 447 | 36 | 416 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 |
| PDB | 3vnz_A | 0.00005 | 60 | 447 | 36 | 416 | A Chain A, Crystal Structure Of Medicago Truncatula Ugt71g1 |
| PDB | 3vny_A | 0.00005 | 60 | 447 | 36 | 416 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
