| Basic Information | |
|---|---|
| Species | Setaria italica |
| Cazyme ID | Si008271m |
| Family | AA7 |
| Protein Properties | Length: 543 Molecular Weight: 59051.4 Isoelectric Point: 9.4522 |
| Chromosome | Chromosome/Scaffold: 4 Start: 28707688 End: 28709316 |
| Description | FAD-binding Berberine family protein |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA7 | 81 | 528 | 0 |
| TPTPVAIIAAADASHVQSAVRCGARHGVRVRPRSGGHDYEGLSYRSLSAVRPFAVVDLAALRAVRVDAGRRTAWVGSGATLGELYYAIANRSARLGFPGG LGPTVGVGGHLSGGGFGLLLRKHGLAADHVLDAVVVDATGTLLDRATMGEDLFWAIRGGGGGSFGVVLSWKLRLVIVPATVTVFTVHRPRNQSATSLLTK WQRVAPTLPPDVFLRIVLQIQDAQFESLYLGTRAGLVATMTRWFPELGVKPEDCIEMTWIESVLYFAFYGTGKPAELLLDRGTKPERYFKAKSDYVTNPI PSHVWERTWSWLLRDGAGLLILDPYGGRMGDVSPSATPFPHRRELYNLQYYGFWFKNGTEEAEKHVGWIRGLHREMEPYVSKNPRGAYVNYRDLDLGVND DGDGGDGVTGYEKARVWGEAYFKGNFERLAAVKAKVDPHDFFRNEQSI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 543 Download |
| MAIVRSFALP LLAAFFSIQH HVVASVTPAA ATAAPSPDTA SFLRCLAVDI PPQVVYTNAS 60 PSYNSVLESS IKNLLFVTPS TPTPVAIIAA ADASHVQSAV RCGARHGVRV RPRSGGHDYE 120 GLSYRSLSAV RPFAVVDLAA LRAVRVDAGR RTAWVGSGAT LGELYYAIAN RSARLGFPGG 180 LGPTVGVGGH LSGGGFGLLL RKHGLAADHV LDAVVVDATG TLLDRATMGE DLFWAIRGGG 240 GGSFGVVLSW KLRLVIVPAT VTVFTVHRPR NQSATSLLTK WQRVAPTLPP DVFLRIVLQI 300 QDAQFESLYL GTRAGLVATM TRWFPELGVK PEDCIEMTWI ESVLYFAFYG TGKPAELLLD 360 RGTKPERYFK AKSDYVTNPI PSHVWERTWS WLLRDGAGLL ILDPYGGRMG DVSPSATPFP 420 HRRELYNLQY YGFWFKNGTE EAEKHVGWIR GLHREMEPYV SKNPRGAYVN YRDLDLGVND 480 DGDGGDGVTG YEKARVWGEA YFKGNFERLA AVKAKVDPHD FFRNEQSIPP LPSSRKGLSV 540 VT* |
| Functional Domains Download unfiltered results here | ||||||
|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description |
| COG0277 | GlcD | 2.0e-5 | 84 | 531 | 482 | + FAD/FMN-containing dehydrogenases [Energy production and conversion] |
| pfam01565 | FAD_binding_4 | 9.0e-9 | 84 | 169 | 86 | + FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan. |
| pfam08031 | BBE | 1.0e-14 | 467 | 529 | 63 | + Berberine and berberine like. This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine. |
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAD54128.1 | 0 | 38 | 535 | 34 | 530 | putative CPRD2 [Oryza sativa Japonica Group] |
| GenBank | EAZ01286.1 | 0 | 6 | 533 | 7 | 531 | hypothetical protein OsI_23311 [Oryza sativa Indica Group] |
| RefSeq | NP_001057827.1 | 0 | 6 | 533 | 7 | 534 | Os06g0548200 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001130124.1 | 0 | 3 | 519 | 2 | 520 | hypothetical protein LOC100191218 [Zea mays] |
| RefSeq | XP_002438539.1 | 0 | 23 | 538 | 4 | 518 | hypothetical protein SORBIDRAFT_10g021670 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4dns_B | 0 | 42 | 531 | 13 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 4dns_A | 0 | 42 | 531 | 13 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 3tsj_B | 0 | 35 | 531 | 4 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 3tsj_A | 0 | 35 | 531 | 4 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 3tsh_A | 0 | 35 | 531 | 4 | 496 | A Chain A, Crystal Structure Of Phl P 4, A Grass Pollen Allergen With Glucose Dehydrogenase Activity |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cannabinoid biosynthesis | RXN-7854 | EC-1.21.3 | tetrahydrocannabinolic acid synthase |
