| Basic Information | |
|---|---|
| Species | Setaria italica |
| Cazyme ID | Si009392m |
| Family | GH89 |
| Protein Properties | Length: 798 Molecular Weight: 91368.9 Isoelectric Point: 6.471 |
| Chromosome | Chromosome/Scaffold: 7 Start: 31721224 End: 31731077 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 103 | 444 | 0 |
| PEILILGVSGVEISAGFHWYLKNYCAAHISWYKTGGAQLSSIPHPGSLPRVPAAGVFIQRPVDWSYYQNAVTSSYSFAWWDWERWEKEIDWMALQGINLP LAFTGQESIWQRVFQRYNISKSDLDDFFGGPAFLAWSRMANMHGWGGPLPQTWLDDQLALQKKILSRMYAFGMFPVLPAFSGNIPAALKSKYPSAKVTHL GNWFTVDSNPRWCCTYLLDASDPLFIEIGKLFIEEQIREYGRTSHIYNCDTFDENTPPLSDPNYISSLGAATFRGMQSGDDDAIWLMQGWLFTYDPFWEP PQMKALLHSVPVGRMIVLDLYAEVKPVWINSDQFYGVPYIWK | |||
| GH89 | 445 | 774 | 0 |
| VGIGMSMEGIEQNPIVYDLMSEMAFHHRQVDLQVWVETYPTRRYGKSVKGLQDAWWILYQTLYNCTDGKNDKNRDVIVAFPDVEPFVIKTQGLYMSSGKQ YSTIPPKNYEKGTSNDAYDHPHLWYNTSVVVHALELFLQYGDEVSDSNTFRYDLVDLTRQVLAKYANDIFIKIIKSYKSNSTNQMITLCQHFLGLVNDLD TLLGSHEGFLLGPWLQNAKGLAQDREQEIQYEWNARTQITMWFDNTETKASLLRDYANKYWSGLLRDYYGPRAAIYFKHLLLSMEKNAPFSLEEWRREWI SLTNNWQSDRKVFATTATGDALNISRSLYM | |||
| Full Sequence |
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| Protein Sequence Length: 798 Download |
| MRPSSGPASR FLTLLLVVVI ACAVPRVRCS DRRFPHLDRV RELHRREGSS SAEQEAAARG 60 LLERILPSHS ASFEFRIISK EQCGGKACFI ISNHPLFDGE GTPEILILGV SGVEISAGFH 120 WYLKNYCAAH ISWYKTGGAQ LSSIPHPGSL PRVPAAGVFI QRPVDWSYYQ NAVTSSYSFA 180 WWDWERWEKE IDWMALQGIN LPLAFTGQES IWQRVFQRYN ISKSDLDDFF GGPAFLAWSR 240 MANMHGWGGP LPQTWLDDQL ALQKKILSRM YAFGMFPVLP AFSGNIPAAL KSKYPSAKVT 300 HLGNWFTVDS NPRWCCTYLL DASDPLFIEI GKLFIEEQIR EYGRTSHIYN CDTFDENTPP 360 LSDPNYISSL GAATFRGMQS GDDDAIWLMQ GWLFTYDPFW EPPQMKALLH SVPVGRMIVL 420 DLYAEVKPVW INSDQFYGVP YIWKVGIGMS MEGIEQNPIV YDLMSEMAFH HRQVDLQVWV 480 ETYPTRRYGK SVKGLQDAWW ILYQTLYNCT DGKNDKNRDV IVAFPDVEPF VIKTQGLYMS 540 SGKQYSTIPP KNYEKGTSND AYDHPHLWYN TSVVVHALEL FLQYGDEVSD SNTFRYDLVD 600 LTRQVLAKYA NDIFIKIIKS YKSNSTNQMI TLCQHFLGLV NDLDTLLGSH EGFLLGPWLQ 660 NAKGLAQDRE QEIQYEWNAR TQITMWFDNT ETKASLLRDY ANKYWSGLLR DYYGPRAAIY 720 FKHLLLSMEK NAPFSLEEWR REWISLTNNW QSDRKVFATT ATGDALNISR SLYMKYLRNA 780 DLLELEGTFS PGKSASL* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 1.0e-21 | 61 | 153 | 93 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 9.0e-95 | 479 | 776 | 298 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 9.0e-163 | 168 | 473 | 339 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAE04506.2 | 0 | 22 | 787 | 18 | 817 | OSJNBb0059K02.16 [Oryza sativa (japonica cultivar-group)] |
| EMBL | CAJ86183.1 | 0 | 22 | 704 | 18 | 687 | H0212B02.15 [Oryza sativa (indica cultivar-group)] |
| GenBank | EEC78143.1 | 0 | 22 | 787 | 18 | 817 | hypothetical protein OsI_17702 [Oryza sativa Indica Group] |
| GenBank | EEE61812.1 | 0 | 32 | 787 | 328 | 1117 | hypothetical protein OsJ_16433 [Oryza sativa Japonica Group] |
| RefSeq | XP_002280399.1 | 0 | 36 | 785 | 30 | 813 | PREDICTED: hypothetical protein [Vitis vinifera] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 59 | 766 | 175 | 866 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vcb_A | 0 | 59 | 766 | 175 | 866 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vca_A | 0 | 59 | 766 | 175 | 866 | A Chain A, Crystal Structure Of Brassica Juncea Chitinase Catalytic Module (Bjchi3) |
| PDB | 2vc9_A | 0 | 59 | 766 | 175 | 866 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 59 | 766 | 198 | 889 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
