Basic Information | |
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Species | Setaria italica |
Cazyme ID | Si017359m |
Family | GT47 |
Protein Properties | Length: 413 Molecular Weight: 46649.5 Isoelectric Point: 9.3406 |
Chromosome | Chromosome/Scaffold: 1 Start: 5531137 End: 5535119 |
Description | Exostosin family protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 88 | 365 | 0 |
ERNFKVYIYPDGDPKTFYQTPRKLTGKYASEGYFFQNIRESRFRTDDPDEAHLFFVPISPHKMRGKGTSYENMTVIVKDYVEGLINKYPYWNRTLGADHF FVTCHDVGVRAFEGLPFMVKNSIRVVCSPSYNVDFIPHKDIALPQVLQPFALPEGGNDIENRTILGFWAGHRNSKIRVILARFWENDTELAISNNRISRA IGELVYQKQFYRTKFCICPGGSQVNSARISDSIHYGCVPVILSDYYDLPFNDALDWRKFAVVLRERDVYQLKSILKSI |
Full Sequence |
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Protein Sequence Length: 413 Download |
MAGRVPGAAA SSPLPRALLL LAALGLFTLS FLSLRSLRPA AGPSLATATA SSLAAAAADK 60 PRPGLPLRTS SSVYHSPDAF AAGYAEMERN FKVYIYPDGD PKTFYQTPRK LTGKYASEGY 120 FFQNIRESRF RTDDPDEAHL FFVPISPHKM RGKGTSYENM TVIVKDYVEG LINKYPYWNR 180 TLGADHFFVT CHDVGVRAFE GLPFMVKNSI RVVCSPSYNV DFIPHKDIAL PQVLQPFALP 240 EGGNDIENRT ILGFWAGHRN SKIRVILARF WENDTELAIS NNRISRAIGE LVYQKQFYRT 300 KFCICPGGSQ VNSARISDSI HYGCVPVILS DYYDLPFNDA LDWRKFAVVL RERDVYQLKS 360 ILKSISQEEF VSLHKSLVQV QKHFVWHSPP LSYDAFHMVM YELWLRHNVI KY* 420 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 1.0e-59 | 87 | 365 | 297 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ACG33948.1 | 0 | 1 | 412 | 1 | 403 | exostosin-like [Zea mays] |
RefSeq | NP_001046127.1 | 0 | 27 | 412 | 29 | 402 | Os02g0187200 [Oryza sativa (japonica cultivar-group)] |
RefSeq | NP_001132213.1 | 0 | 1 | 412 | 1 | 403 | hypothetical protein LOC100193644 [Zea mays] |
RefSeq | NP_001147269.1 | 0 | 1 | 412 | 1 | 403 | exostosin-like [Zea mays] |
RefSeq | XP_002453426.1 | 0 | 1 | 412 | 1 | 403 | hypothetical protein SORBIDRAFT_04g005890 [Sorghum bicolor] |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |