| Basic Information | |
|---|---|
| Species | Setaria italica |
| Cazyme ID | Si021698m |
| Family | GH79 |
| Protein Properties | Length: 541 Molecular Weight: 59736.6 Isoelectric Point: 5.0697 |
| Chromosome | Chromosome/Scaffold: 3 Start: 46797393 End: 46801617 |
| Description | glucuronidase 1 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 40 | 533 | 0 |
| SDEFVCATIDWWPPEKCNYDQCPWGRASVLNLDLTNPLLAKAIQAFSPLRIRVGGSLQDQVLYGTPNLESPCDPFTKVSGGLFGFSQGCITLERWDAIND LFVNTGAVITFGLNALQGRQQIRRGVWGGPWNSSNAREFMEYTVSKDYPIDSWEFGNELSGSGIGASVGAEQYGKDLVELQTIINELYGDSRRPLVVAPG GFFDQKWFAELLEVSGPNVLNAMTHHIYNLGAGNDPQVPNRILNPQYLSRASDTFRSLQLTIQRHGPWSAPWVGEAGGAYNSGSRLVSNTFLNSFWYLDQ LGQSAKYDTKVYCRQTLIGGNYGLLDTETFVPNPDYYSALLWHRLMGTGVLSTDISGSSYLRAYVHCGKQKGGVAILLLNLHRSMGFMVSVRNDLNVNLA EGQGIRRDNIFVHGLKRTVSWVGSKASDGYSKREEYHLSAKDGNPFARTMLLNGVPLELTEDGDIPPLYPVEVSVNSPIYVAPLTIAFVVFPDF | |||
| Full Sequence |
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| Protein Sequence Length: 541 Download |
| MSLWFIFLLP LLCLPAWVRA EDYSDVTVIV RGSETIASTS DEFVCATIDW WPPEKCNYDQ 60 CPWGRASVLN LDLTNPLLAK AIQAFSPLRI RVGGSLQDQV LYGTPNLESP CDPFTKVSGG 120 LFGFSQGCIT LERWDAINDL FVNTGAVITF GLNALQGRQQ IRRGVWGGPW NSSNAREFME 180 YTVSKDYPID SWEFGNELSG SGIGASVGAE QYGKDLVELQ TIINELYGDS RRPLVVAPGG 240 FFDQKWFAEL LEVSGPNVLN AMTHHIYNLG AGNDPQVPNR ILNPQYLSRA SDTFRSLQLT 300 IQRHGPWSAP WVGEAGGAYN SGSRLVSNTF LNSFWYLDQL GQSAKYDTKV YCRQTLIGGN 360 YGLLDTETFV PNPDYYSALL WHRLMGTGVL STDISGSSYL RAYVHCGKQK GGVAILLLNL 420 HRSMGFMVSV RNDLNVNLAE GQGIRRDNIF VHGLKRTVSW VGSKASDGYS KREEYHLSAK 480 DGNPFARTML LNGVPLELTE DGDIPPLYPV EVSVNSPIYV APLTIAFVVF PDFEAEACGR 540 * |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 25 | 341 | 318 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG27548.1 | 0 | 16 | 540 | 16 | 540 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACR34666.1 | 0 | 16 | 540 | 51 | 575 | unknown [Zea mays] |
| GenBank | EEC69565.1 | 0 | 1 | 540 | 671 | 1237 | hypothetical protein OsI_38868 [Oryza sativa Indica Group] |
| RefSeq | NP_001130921.1 | 0 | 16 | 540 | 42 | 566 | hypothetical protein LOC100192026 [Zea mays] |
| RefSeq | XP_002442385.1 | 0 | 16 | 540 | 16 | 540 | hypothetical protein SORBIDRAFT_08g019250 [Sorghum bicolor] |
