y
Basic Information | |
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Species | Setaria italica |
Cazyme ID | Si021990m |
Family | GT4 |
Protein Properties | Length: 462 Molecular Weight: 51743 Isoelectric Point: 8.7339 |
Chromosome | Chromosome/Scaffold: 3 Start: 47198175 End: 47202146 |
Description | UDP-Glycosyltransferase superfamily protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT4 | 264 | 429 | 1.2e-24 |
TTPPVFISVAQFRPEKAHGLQLEAFALALTRLDPEFPKPKLQFVGSCRNKEDLERLQKLKDRAIELHINELVEFHKDISYMDLVQLLGGAIAGLHSMTDE HFGIVVVEYMAAGAIPIAHKSAGPMMDIVLDEDGHRTGFLASEKEEFADAIIKVLRMSEQERQEMA |
Full Sequence |
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Protein Sequence Length: 462 Download |
MAILAGLAAV FSVLLAAALR RLRLHLGRQP TPAAGFFHPY TNDGGGGERV LWCAVRAVQE 60 LRPGLPCAVF TGDADASPYG LAARALDRFG VRLLCPPQVV HLNKRKWIEA STYPHFTMIG 120 QSLGSVYLAW EALTNFTPQF YFDTSGYAFT YPLALLFGCK VISYTHYPTI SCDMIGRVKQ 180 RSSMYNNNSR IAGSIWLSRC KILYYTIFSW LYGLVGSCAH LVMVNSSWTK SHIINIWKIP 240 ERTKRVYPPC DTSALQMLPL ERSTTPPVFI SVAQFRPEKA HGLQLEAFAL ALTRLDPEFP 300 KPKLQFVGSC RNKEDLERLQ KLKDRAIELH INELVEFHKD ISYMDLVQLL GGAIAGLHSM 360 TDEHFGIVVV EYMAAGAIPI AHKSAGPMMD IVLDEDGHRT GFLASEKEEF ADAIIKVLRM 420 SEQERQEMAA ASRKRAQRFS GQRFHEDFTE AVRPILLLRE S* 480 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam00534 | Glycos_transf_1 | 1.0e-25 | 265 | 435 | 173 | + Glycosyl transferases group 1. Mutations in this domain of human PIGA lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. | ||
cd03801 | GT1_YqgM_like | 1.0e-25 | 196 | 453 | 268 | + This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. | ||
cd03805 | GT1_ALG2_like | 3.0e-34 | 107 | 444 | 354 | + This family is most closely related to the GT1 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans. | ||
PLN02949 | PLN02949 | 0 | 32 | 456 | 425 | + transferase, transferring glycosyl groups | ||
cd03806 | GT1_ALG11_like | 0 | 35 | 447 | 416 | + This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides. |
Gene Ontology | |
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GO Term | Description |
GO:0009058 | biosynthetic process |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | ABA99697.1 | 0 | 29 | 456 | 27 | 454 | glycosyl transferase, group 1 family protein, expressed [Oryza sativa (japonica cultivar-group)] |
GenBank | EAZ21019.1 | 0 | 29 | 456 | 27 | 410 | hypothetical protein OsJ_36668 [Oryza sativa Japonica Group] |
RefSeq | NP_001142345.1 | 0 | 28 | 460 | 27 | 459 | hypothetical protein LOC100274516 [Zea mays] |
RefSeq | XP_002443441.1 | 0 | 33 | 461 | 32 | 460 | hypothetical protein SORBIDRAFT_08g019540 [Sorghum bicolor] |
RefSeq | XP_002528312.1 | 0 | 33 | 456 | 37 | 460 | glycosyl transferase, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3l01_B | 0.000004 | 363 | 451 | 341 | 426 | A Chain A, Crystal Structure Of Monomeric Glycogen Synthase From Pyrococcus Abyssi |
PDB | 3l01_A | 0.000004 | 363 | 451 | 341 | 426 | A Chain A, Crystal Structure Of Monomeric Glycogen Synthase From Pyrococcus Abyssi |
PDB | 3fro_C | 0.000004 | 363 | 451 | 341 | 426 | A Chain A, Crystal Structure Of Pyrococcus Abyssi Glycogen Synthase With Open And Closed Conformations |
PDB | 3fro_B | 0.000004 | 363 | 451 | 341 | 426 | A Chain A, Crystal Structure Of Pyrococcus Abyssi Glycogen Synthase With Open And Closed Conformations |
PDB | 3fro_A | 0.000004 | 363 | 451 | 341 | 426 | A Chain A, Crystal Structure Of Pyrococcus Abyssi Glycogen Synthase With Open And Closed Conformations |
Metabolic Pathways | |||
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Pathway Name | Reaction | EC | Protein Name |
dolichyl-diphosphooligosaccharide biosynthesis | RXN-5464 | EC-2.4.1.131 | GDP-Man:Man3GlcNAc2-PP-Dol α-1,2-mannosyltransferase |