| Basic Information | |
|---|---|
| Species | Setaria italica |
| Cazyme ID | Si022612m |
| Family | GH18 |
| Protein Properties | Length: 335 Molecular Weight: 35945.3 Isoelectric Point: 6.9616 |
| Chromosome | Chromosome/Scaffold: 3 Start: 48311711 End: 48312725 |
| Description | |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH18 | 91 | 254 | 4.8e-21 |
| GRFVVYWDEANLTPAAVAAAKHRGGGSADNKNNVRVALSLGGDTVHGANATFRASSVDAWVANAVASLTEILTTYGLDGIDVDYEHFGERETPEVFAECV GRLVRALRALGVISFASVAPFANPDVQAHYGELWRRYGREFDYVNFQFYAYAANTTVAEFLGYY | |||
| Full Sequence |
|---|
| Protein Sequence Length: 335 Download |
| MASLHQRITA MVRTLFPFLL LFVVGATATA SASSGARRPL FREYIGAEGK NVTFADVPVH 60 PGVDFHFILS FAIDYAVDAA NASAPPQPTD GRFVVYWDEA NLTPAAVAAA KHRGGGSADN 120 KNNVRVALSL GGDTVHGANA TFRASSVDAW VANAVASLTE ILTTYGLDGI DVDYEHFGER 180 ETPEVFAECV GRLVRALRAL GVISFASVAP FANPDVQAHY GELWRRYGRE FDYVNFQFYA 240 YAANTTVAEF LGYYNEQSSR YAGGGGKVLV GFGTDPASNG LGPGKGFFRA CRELRRQGRL 300 HGVFVWAADN SAADGFRYER VAQRFLAGAA PGFT* 360 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd06546 | GH18_CTS3_chitinase | 2.0e-5 | 87 | 239 | 166 | + GH18 domain of CTS3 (chitinase 3), an uncharacterized protein from the human fungal pathogen Coccidioides posadasii. CTS3 has a chitinase-like glycosyl hydrolase family 18 (GH18) domain; and has homologs in bacteria as well as fungi. | ||
| cd02871 | GH18_chitinase_D-like | 2.0e-8 | 51 | 239 | 202 | + GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (GH18) domain, a chitin-binding domain, and a fibronectin type III domain. The chitin-binding and fibronectin type III domains are located either N-terminal or C-terminal to the catalytic domain. This family includes exochitinase Chi36 from Bacillus cereus. | ||
| cd00598 | GH18_chitinase-like | 1.0e-10 | 66 | 239 | 178 | + The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model. | ||
| pfam00704 | Glyco_hydro_18 | 5.0e-11 | 123 | 242 | 122 | + Glycosyl hydrolases family 18. | ||
| cd06544 | GH18_narbonin | 2.0e-100 | 40 | 311 | 272 | + Narbonin is a plant 2S protein from the globulin fraction of narbon bean (Vicia narbonensis L.) cotyledons with unknown function. Narbonin has a glycosyl hydrolase family 18 (GH18) domain without the conserved catalytic residues and with no known enzymatic activity. Narbonin amounts to up to 3% of the total seed globulins of mature seeds and was thought to be a storage protein but was found to degrade too slowly during germination. This family also includes the VfNOD32 nodulin from Vicia faba. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABD32310.1 | 0 | 17 | 328 | 8 | 302 | Glycoside hydrolase, family 18 [Medicago truncatula] |
| RefSeq | NP_001144844.1 | 0 | 34 | 305 | 30 | 296 | hypothetical protein LOC100277930 [Zea mays] |
| RefSeq | XP_002318148.1 | 0 | 18 | 327 | 3 | 298 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002443505.1 | 0 | 38 | 333 | 40 | 336 | hypothetical protein SORBIDRAFT_08g020700 [Sorghum bicolor] |
| RefSeq | XP_002532811.1 | 0 | 11 | 327 | 3 | 302 | Chitinase 1 precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3sim_B | 0 | 40 | 326 | 2 | 273 | A Chain A, Crystallographic Structure Analysis Of Family 18 Chitinase From Crocus Vernus |
| PDB | 3sim_A | 0 | 40 | 326 | 2 | 273 | A Chain A, Crystallographic Structure Analysis Of Family 18 Chitinase From Crocus Vernus |
| PDB | 1nar_A | 1e-26 | 38 | 327 | 2 | 288 | A Chain A, Crystal Structure Of Narbonin Refined At 1.8 Angstroms Resolution |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| chitin degradation II | 3.2.1.14-RXN | EC-3.2.1.14 | chitinase |
| chitin degradation II | RXN-12623 | EC-3.2.1.14 | chitinase |
| chitin degradation II | RXN-12624 | EC-3.2.1.14 | chitinase |
| chitin degradation III (carnivorous plants) | 3.2.1.14-RXN | EC-3.2.1.14 | chitinase |
