| Basic Information | |
|---|---|
| Species | Setaria italica |
| Cazyme ID | Si026223m |
| Family | AA7 |
| Protein Properties | Length: 522 Molecular Weight: 56341.4 Isoelectric Point: 8.8025 |
| Chromosome | Chromosome/Scaffold: 8 Start: 23712383 End: 23714077 |
| Description | FAD-binding Berberine family protein |
| View CDS | |
| External Links |
|---|
| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA7 | 63 | 515 | 0 |
| NTTVRPLCIVTASDVSHVQAAVRCGRWHGVRLRVRSGGHDYEGLSYRSVQPEVFAVLDLARLRGVRVVPGEGSAWVDAGTTLGELYYAVGTANPGFLFPG GACATVGVSGFISGGGIGLMMRKYGVGGDNVLDARIVNAAGDVLDRAAMGEDLFWAIRGGGGESFGVVVAWRLKLSAVPPTVTVVNNLRTMEQGVAYLLA KWETTILSPSLPADLTIRVVLQERHAFFQTLYLGRCSELLATARGVFPELGMTAADCNEMSWLRAMAFIYFGNAATPPEALLNRTNSLGTYFKSKSDYVR RAVGKAGWDALFQQWLSKNGNGLMILEPHGGAVGGANTATTSPYPHRRGVLFNIQYGSMWWGEANGTAAAAALRWLDGLYGFLGQYATSNPREAFANYRD LDLGQNVVGRDGVSSYRSGRVWAEKYFMGNYRRLAAVKAMVDPSDYFRNEQSI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 522 Download |
| MALVLAILCF LCGNAILPSS ASSDSFLQCL TSMMPSELVY QQSSSGFMSV LQSSIQNPKF 60 LTNTTVRPLC IVTASDVSHV QAAVRCGRWH GVRLRVRSGG HDYEGLSYRS VQPEVFAVLD 120 LARLRGVRVV PGEGSAWVDA GTTLGELYYA VGTANPGFLF PGGACATVGV SGFISGGGIG 180 LMMRKYGVGG DNVLDARIVN AAGDVLDRAA MGEDLFWAIR GGGGESFGVV VAWRLKLSAV 240 PPTVTVVNNL RTMEQGVAYL LAKWETTILS PSLPADLTIR VVLQERHAFF QTLYLGRCSE 300 LLATARGVFP ELGMTAADCN EMSWLRAMAF IYFGNAATPP EALLNRTNSL GTYFKSKSDY 360 VRRAVGKAGW DALFQQWLSK NGNGLMILEP HGGAVGGANT ATTSPYPHRR GVLFNIQYGS 420 MWWGEANGTA AAAALRWLDG LYGFLGQYAT SNPREAFANY RDLDLGQNVV GRDGVSSYRS 480 GRVWAEKYFM GNYRRLAAVK AMVDPSDYFR NEQSIPPLPK F* 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PLN02805 | PLN02805 | 0.003 | 68 | 270 | 227 | + D-lactate dehydrogenase [cytochrome] | ||
| pfam08031 | BBE | 9.0e-14 | 456 | 516 | 61 | + Berberine and berberine like. This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine. | ||
| pfam01565 | FAD_binding_4 | 4.0e-19 | 68 | 207 | 141 | + FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan. | ||
| COG0277 | GlcD | 1.0e-19 | 65 | 277 | 232 | + FAD/FMN-containing dehydrogenases [Energy production and conversion] | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABA93766.1 | 0 | 1 | 518 | 10 | 536 | Reticuline oxidase precursor, putative [Oryza sativa (japonica cultivar-group)] |
| GenBank | EAY80999.1 | 0 | 1 | 518 | 10 | 536 | hypothetical protein OsI_36182 [Oryza sativa Indica Group] |
| GenBank | EEC80786.1 | 0 | 1 | 518 | 8 | 519 | hypothetical protein OsI_23315 [Oryza sativa Indica Group] |
| RefSeq | NP_001067934.1 | 0 | 1 | 482 | 10 | 500 | Os11g0495700 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002438541.1 | 0 | 1 | 517 | 7 | 522 | hypothetical protein SORBIDRAFT_10g021685 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3tsj_B | 0 | 17 | 520 | 2 | 498 | A Chain A, Crystal Structure Of Human Glutathione Peroxidase 5 |
| PDB | 3tsj_A | 0 | 17 | 520 | 2 | 498 | A Chain A, Crystal Structure Of Human Glutathione Peroxidase 5 |
| PDB | 3tsh_A | 0 | 17 | 520 | 2 | 498 | A Chain A, Crystal Structure Of Phl P 4, A Grass Pollen Allergen With Glucose Dehydrogenase Activity |
| PDB | 4dns_B | 0 | 25 | 518 | 12 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 4dns_A | 0 | 25 | 518 | 12 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cannabinoid biosynthesis | RXN-7854 | EC-1.21.3 | tetrahydrocannabinolic acid synthase |
