| Basic Information | |
|---|---|
| Species | Setaria italica |
| Cazyme ID | Si027882m |
| Family | AA7 |
| Protein Properties | Length: 520 Molecular Weight: 56818.9 Isoelectric Point: 7.9825 |
| Chromosome | Chromosome/Scaffold: 8 Start: 23728931 End: 23730490 |
| Description | FAD-binding Berberine family protein |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA7 | 62 | 512 | 0 |
| TNTTVRPLCIVTASGIPHVQAAVRCGRAHGVRLRVRSGGHDYEGLSYRSVQPEVFAVLDLSRVRAVDVRPFEATAWVDAGATLGELYYAIGTASPRLAFP GGACPTVGVSGYLSGGGIGLMMRRFGIGADNVIDARIVNAGGELIDSVASMDQDLFWAIRGGGGESFGVVVAWRLRLSMVEETVTVVNLQRTLDEGAAAI VAKWETLILQPYVPDLTIRVVVQDNHAFFQTLFLGRCSRLLRTMRAYFPELGMTPADCREMTWLRAMAFIGLNGDANAPPEALLNRTNNLGTYVKNKSDY VRRAIGRAGWEGIFREHLSRYGPGLMIMEPHGGAVPNFATPYPHRQGVLYNIQYVVFWGGEADGTAAAAASGWLGGIYGYMEQFVTSNPREAFANYRDLE IGANVVGGDGVTTYESGRVWGEKYFMGNFRRLAAVKGRVDPGDYFRNEQSI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 520 Download |
| MARILLTLCF LSCNVFLRSF ATSDDFLQCL SQTIPSELVY QQSSSSFMSV LQSSVQNPKY 60 LTNTTVRPLC IVTASGIPHV QAAVRCGRAH GVRLRVRSGG HDYEGLSYRS VQPEVFAVLD 120 LSRVRAVDVR PFEATAWVDA GATLGELYYA IGTASPRLAF PGGACPTVGV SGYLSGGGIG 180 LMMRRFGIGA DNVIDARIVN AGGELIDSVA SMDQDLFWAI RGGGGESFGV VVAWRLRLSM 240 VEETVTVVNL QRTLDEGAAA IVAKWETLIL QPYVPDLTIR VVVQDNHAFF QTLFLGRCSR 300 LLRTMRAYFP ELGMTPADCR EMTWLRAMAF IGLNGDANAP PEALLNRTNN LGTYVKNKSD 360 YVRRAIGRAG WEGIFREHLS RYGPGLMIME PHGGAVPNFA TPYPHRQGVL YNIQYVVFWG 420 GEADGTAAAA ASGWLGGIYG YMEQFVTSNP REAFANYRDL EIGANVVGGD GVTTYESGRV 480 WGEKYFMGNF RRLAAVKGRV DPGDYFRNEQ SIPPLRQGF* 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| TIGR01679 | bact_FAD_ox | 0.007 | 93 | 237 | 156 | + FAD-linked oxidoreductase. This model represents a family of bacterial oxidoreductases with covalently linked FAD, closely related to two different eukaryotic oxidases, L-gulonolactone oxidase (EC 1.1.3.8) from rat and D-arabinono-1,4-lactone oxidase (EC 1.1.3.37) from Saccharomyces cerevisiae. | ||
| pfam08031 | BBE | 6.0e-13 | 453 | 513 | 61 | + Berberine and berberine like. This domain is found in the berberine bridge and berberine bridge- like enzymes which are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine. | ||
| COG0277 | GlcD | 1.0e-16 | 65 | 275 | 219 | + FAD/FMN-containing dehydrogenases [Energy production and conversion] | ||
| pfam01565 | FAD_binding_4 | 2.0e-17 | 68 | 207 | 141 | + FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar to oxygen oxidoreductase. One of the enzymes Vanillyl-alcohol oxidase (VAO) has a solved structure, the alignment includes the FAD binding site, called the PP-loop, between residues 99-110. The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. VAO catalyzes the oxidation of a wide variety of substrates, ranging form aromatic amines to 4-alkylphenols. Other members of this family include D-lactate dehydrogenase, this enzyme catalyzes the conversion of D-lactate to pyruvate using FAD as a co-factor; mitomycin radical oxidase, this enzyme oxidises the reduced form of mitomycins and is involved in mitomycin resistance. This family includes MurB an UDP-N-acetylenolpyruvoylglucosamine reductase enzyme EC:1.1.1.158. This enzyme is involved in the biosynthesis of peptidoglycan. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity |
| GO:0016491 | oxidoreductase activity |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABA93766.1 | 0 | 1 | 519 | 10 | 540 | Reticuline oxidase precursor, putative [Oryza sativa (japonica cultivar-group)] |
| GenBank | EAY80999.1 | 0 | 1 | 519 | 10 | 540 | hypothetical protein OsI_36182 [Oryza sativa Indica Group] |
| GenBank | EAZ01289.1 | 0 | 17 | 515 | 26 | 522 | hypothetical protein OsI_23318 [Oryza sativa Indica Group] |
| RefSeq | NP_001067934.1 | 0 | 1 | 479 | 10 | 500 | Os11g0495700 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002438541.1 | 0 | 1 | 514 | 7 | 522 | hypothetical protein SORBIDRAFT_10g021685 [Sorghum bicolor] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3tsj_B | 0 | 21 | 519 | 6 | 500 | A Chain A, Beta-Glycosidase From Pyrococcus Horikoshii |
| PDB | 3tsj_A | 0 | 21 | 519 | 6 | 500 | A Chain A, Beta-Glycosidase From Pyrococcus Horikoshii |
| PDB | 3tsh_A | 0 | 21 | 519 | 6 | 500 | A Chain A, Crystal Structure Of Phl P 4, A Grass Pollen Allergen With Glucose Dehydrogenase Activity |
| PDB | 4dns_B | 0 | 25 | 515 | 12 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| PDB | 4dns_A | 0 | 25 | 515 | 12 | 496 | A Chain A, Crystal Structure Of Bermuda Grass Isoallergen Bg60 Provides Insight Into The Various Cross-Allergenicity Of The Pollen Group 4 Allergens |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cannabinoid biosynthesis | RXN-7854 | EC-1.21.3 | tetrahydrocannabinolic acid synthase |
