Basic Information | |
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Species | Setaria italica |
Cazyme ID | Si033881m |
Family | GT24 |
Protein Properties | Length: 1559 Molecular Weight: 176835 Isoelectric Point: 5.4116 |
Chromosome | Chromosome/Scaffold: 9 Start: 16773143 End: 16788573 |
Description | UDP-glucose:glycoprotein glucosyltransferases;transferases, transferring hexosyl groups;transferases, transferring glycosyl groups |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT24 | 1254 | 1501 | 0 |
INIFSVASGHLYERFLKIMILSVLKKTQRPVKFWFIKNYLSPQFKDVIPHMAQEYGFEYELITYKWPTWLHKQKEKQRIIWAYKILFLDVIFPLSLRKVI FVDADQIVRADMGELYDMNLKGRPLAYTPFCDNNKDMDGYRFWKQGFWKDHLRGRPYHISALYVVDLAKFRQTAAGDTLRVIYEQLSKDPNSLSNLDQDL PNYAQHTVPIFSLPQEWLWCESWCGNATKARAKTIDLCNNPMTKEPKL |
Full Sequence |
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Protein Sequence Length: 1559 Download |
MFISELLSKE WKDLFWDFID HWKELDKGSE CLTAKCCVQK IVEDTRTLLN EPLSSVFEFS 60 LTLRSASPRL VLYRQLAEES LSSVSINDSQ EQISGHGTGE NFDRAVGPSS SGGTCCWVDT 120 GNAPLFTSGD LHEWLEGLGK LAMDSTEQPE LFDFDHVYPR ANVTAPIAIF YGAVGTKCFK 180 ELHVQLAEAS KQGKVRYALR PVLPSGCQAT SSFCGSIGAV DAVTLSGYGV ELALKNMEYK 240 AMDDTAIKKG VSLEDPKTED LSQEVRGFIF SKILERKPEL NAEIMAFRDY LLSSTVSDTL 300 EVWELKDLGH QTAQRIVQAS DPLQSMQEIN QNFPSIVSSL SRMKLDNSIK DEIIANQRMV 360 PPGKSLMALN GALINIEDLD LYLLMDMVHG ELSLADQFAR LKLPQSAAHK ILSAPPPAES 420 NSFRVDFRSS HVHYLNNLEE DTMYRRWRSN LQELLMPVFP GQMRYIRKNL FHAVYVLDPA 480 SACGAETIDM VLSLYQDNVP IRFGIIMYSS RFINVIEESD GTLPINDGED TSILITRLFL 540 YIKETYSTQL AFEFLSNIHK SRNGEDDYNE DLIEAHHVEG AFVDSLLSSA KSHPQDVLLK 600 LQKENMYREE AEQSSRFVHK LGLYKLQCCL LMNGLVHEAN EDATMNAMND ELPRIQEQVY 660 YGHIQSHTDV LEKFLSESSY KRYNPSITGK SAGKKFVSLF ASYHQEDSVF NDIKYLQSPA 720 TVDDAKPVTH LLAIDLSSKV GIKLLHEAIR YLMDGTNRGR VGLLLYVRTA SSLPILLLKD 780 IFDRTISSFS YKEKVLVFLH EVLKFYGAQP TPVSSVAGDW TRTMMEKVYS LAAEIALPVD 840 DYKAWFESFS ADTVLKGMDK LSDFVFGQLG LVFGSNAVIT NGRVFVMKEG EPFLADDLGL 900 LESMEYDLRT KYIFEIIEEV EFAGVDPDDL TSQFYSDIAM LISSSMSVRE RPSERAHFEI 960 LHAEHSAIRL NNENSSIHID AVIDPLSPTG QKLAPLLRIL WKQIQPSMRI VLNPISSLAD 1020 LPLKNFYRFV LPSMDDFSST DYSVHGPKAF FANMPLSKTL TMNIDVPEPW LVEPVVAIHD 1080 LDNILLENLG DVRTLQAVFE LEALLLTGHC MEKDRDPPRG LQFILGTKQR PHLVDTLVMA 1140 NLGYWQMKVS PGVWYLQLAP GRSADLYELP PKLIAIDSLR GKLMHIEVQK KKGKEREELL 1200 NAADDHHFQE KMDNKGWNNN LLKWASSLIN GDASSKNKAD KITDRKDARQ GETINIFSVA 1260 SGHLYERFLK IMILSVLKKT QRPVKFWFIK NYLSPQFKDV IPHMAQEYGF EYELITYKWP 1320 TWLHKQKEKQ RIIWAYKILF LDVIFPLSLR KVIFVDADQI VRADMGELYD MNLKGRPLAY 1380 TPFCDNNKDM DGYRFWKQGF WKDHLRGRPY HISALYVVDL AKFRQTAAGD TLRVIYEQLS 1440 KDPNSLSNLD QDLPNYAQHT VPIFSLPQEW LWCESWCGNA TKARAKTIDL CNNPMTKEPK 1500 LQGARRIVPE WVGLDSEARH FTARILGDNL ESPEATSPPS ETPKPDDKDT DQNVKDEL* 1560 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam01501 | Glyco_transf_8 | 0.0002 | 1258 | 1453 | 204 | + Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase. | ||
cd04194 | GT8_A4GalT_like | 2.0e-12 | 1254 | 1470 | 226 | + A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS. | ||
cd00505 | Glyco_transf_8 | 2.0e-56 | 1254 | 1501 | 257 | + Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+. | ||
pfam06427 | UDP-g_GGTase | 1.0e-83 | 936 | 1141 | 212 | + UDP-glucose:Glycoprotein Glucosyltransferase. The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase. | ||
cd06432 | GT8_HUGT1_C_like | 9.0e-174 | 1254 | 1501 | 248 | + The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity. |
Gene Ontology | |
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GO Term | Description |
GO:0003980 | UDP-glucose:glycoprotein glucosyltransferase activity |
GO:0006486 | protein glycosylation |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
DDBJ | BAD28382.1 | 0 | 9 | 1548 | 63 | 1619 | putative UDP-glucose:glycoprotein glucosyltransferase [Oryza sativa Japonica Group] |
GenBank | EEC73742.1 | 0 | 9 | 1243 | 63 | 1292 | hypothetical protein OsI_08377 [Oryza sativa Indica Group] |
GenBank | EEE57527.1 | 0 | 28 | 1548 | 49 | 1590 | hypothetical protein OsJ_07839 [Oryza sativa Japonica Group] |
RefSeq | XP_002268972.1 | 0 | 9 | 1558 | 59 | 1611 | PREDICTED: similar to EBS1 (EMS-MUTAGENIZED BRI1 SUPPRESSOR 1); UDP-glucose:glycoprotein glucosyltransferase/ transferase, transferring glycosyl groups / transferase, transferring hexosyl groups [Vitis vinifera] |
RefSeq | XP_002454743.1 | 0 | 9 | 1558 | 65 | 1568 | hypothetical protein SORBIDRAFT_04g036540 [Sorghum bicolor] |
EST Download unfiltered results here | ||||
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Hit | Length | Start | End | EValue |
HO415354 | 543 | 1007 | 1525 | 0 |
GO883503 | 315 | 1215 | 1529 | 0 |
FG395906 | 283 | 1213 | 1495 | 0 |
JG938854 | 283 | 1210 | 1492 | 0 |
HO415354 | 140 | 874 | 1008 | 4e-18 |
Sequence Alignments (This image is cropped. Click for full image.) |
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