| Basic Information | |
|---|---|
| Species | Setaria italica |
| Cazyme ID | Si035071m |
| Family | GH79 |
| Protein Properties | Length: 541 Molecular Weight: 60251.6 Isoelectric Point: 7.9607 |
| Chromosome | Chromosome/Scaffold: 9 Start: 53167178 End: 53171112 |
| Description | glucuronidase 2 |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH79 | 43 | 534 | 0 |
| DESYVCATIDWWPPEKCNYNQCPWGQSSILNLDLDHPFLAQAIQAFDNLRIRLGGSLQDRVVYDVGAESPCTPFRNMSNGLFGFSVGCLSMDRWDKLNDL FQKTGAIVTFGVNALYGRYNVRRSIWAGKWNSTNAYDFVKYTISKGYPVGSWEFGNELSGHGIGAKVDAKLYGKDVIEFKSILQQLYKAPLSQPLLLAPG GFFDQQWYSQLLQTSGHGVVNALTHHVYNLGGGDDVHLIRKILDPKYLDRAEDTYRDMQLTIQRHGTWTSAWVSESGGVFNNGGPLVSNTFINSIWYLDQ LGMASKYNTKVFCRQTLIGGNYGLLDTQTFLPNPDYYSALLWHRLMGNGVLSIDSIAPRRLRAYAHCRRQQQGITLLLINLSNTTGYNVTLQNDINIGKR PDLEKRSSFSHRLRKAVSWLGSKASSDTKKREEYHLTPKDGDVQSKTMLLNGVQLELGDDGSVPAMNPVLAAVDSPVYLAPTSIAFIVLPEF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 541 Download |
| MEVRLLLLLA LICLHAAPRW ASAQQPEEAT VIVKGSTRIA ETDESYVCAT IDWWPPEKCN 60 YNQCPWGQSS ILNLDLDHPF LAQAIQAFDN LRIRLGGSLQ DRVVYDVGAE SPCTPFRNMS 120 NGLFGFSVGC LSMDRWDKLN DLFQKTGAIV TFGVNALYGR YNVRRSIWAG KWNSTNAYDF 180 VKYTISKGYP VGSWEFGNEL SGHGIGAKVD AKLYGKDVIE FKSILQQLYK APLSQPLLLA 240 PGGFFDQQWY SQLLQTSGHG VVNALTHHVY NLGGGDDVHL IRKILDPKYL DRAEDTYRDM 300 QLTIQRHGTW TSAWVSESGG VFNNGGPLVS NTFINSIWYL DQLGMASKYN TKVFCRQTLI 360 GGNYGLLDTQ TFLPNPDYYS ALLWHRLMGN GVLSIDSIAP RRLRAYAHCR RQQQGITLLL 420 INLSNTTGYN VTLQNDINIG KRPDLEKRSS FSHRLRKAVS WLGSKASSDT KKREEYHLTP 480 KDGDVQSKTM LLNGVQLELG DDGSVPAMNP VLAAVDSPVY LAPTSIAFIV LPEFEAKACS 540 * |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 26 | 344 | 320 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACG44916.1 | 0 | 17 | 540 | 16 | 541 | heparanase-like protein 2 precursor [Zea mays] |
| GenBank | ACV84153.1 | 0 | 1 | 540 | 1 | 542 | heparanase [Oryza sativa Indica Group] |
| RefSeq | NP_001049350.1 | 0 | 1 | 540 | 1 | 541 | Os03g0211700 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | NP_001145968.1 | 0 | 17 | 540 | 16 | 541 | hypothetical protein LOC100279495 [Zea mays] |
| RefSeq | XP_002468296.1 | 0 | 12 | 540 | 14 | 543 | hypothetical protein SORBIDRAFT_01g043180 [Sorghum bicolor] |
