Basic Information | |
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Species | Thellungiella halophila |
Cazyme ID | Thhalv10006680m |
Family | CBM57 |
Protein Properties | Length: 1001 Molecular Weight: 111077 Isoelectric Point: 7.7252 |
Chromosome | Chromosome/Scaffold: 5 Start: 4902738 End: 4907834 |
Description | Leucine-rich repeat transmembrane protein kinase |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
CBM57 | 405 | 576 | 3.6e-26 |
HINCGGPDVIIENTRGRFLYEGDNNGLTGSATNYHGKSWGFSNTGDFMDDAITEDTYSISSESLVSAKYPELYQTARRSPLSLAYFAFCFENGSYNAKLH FAEIQFSDEEPYAKLAKRIFNIYVQGKLIWRDFSIRDEANGTHKEVIKEVNVTVTDNTLEIRLYWAGKGTTI |
Full Sequence |
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Protein Sequence Length: 1001 Download |
MIMLRSRLFS SVIFVLTLIY LVCTVSASPS LHPDEVEALK DIASTLGVKY LNLSEDPCLT 60 KTLVITQDVL KEGQNSTIRC DCHFNNNNTC HITHFIIKTF SLPGKLPPEF SRLRYLELID 120 LCRNYLYGSI PMEWASLPFL KSISVCANRL SGDIPKGLGK FINLTLLVLE ANQFSGTIPK 180 KLGKLVNLDG LTLSSNQLVG GVPKTLARLK NLTNLRFSDN RLNGSIPEFI GNLSKLERLE 240 LYASGLTEPI PESIFRLENL VDLRISDTTA GLGQFPLITS KKLKFLVLRN MNLTGTIPTS 300 IWNLPNLMTL DVSFNRLTGE IPADARAPKY TYLAGNMLSG KVDSGPFITA STNIDLSYNN 360 FTWSPSCRER KNVNTYESSR SRNSLTRILP CSAIKQCQNY SRSLHINCGG PDVIIENTRG 420 RFLYEGDNNG LTGSATNYHG KSWGFSNTGD FMDDAITEDT YSISSESLVS AKYPELYQTA 480 RRSPLSLAYF AFCFENGSYN AKLHFAEIQF SDEEPYAKLA KRIFNIYVQG KLIWRDFSIR 540 DEANGTHKEV IKEVNVTVTD NTLEIRLYWA GKGTTIIPKR GNYGSLISAI SVCPSSESEC 600 GVPVQILPVT KEQKPRTYPL VLGITVLIIS LAFLILGTFY WKKCVSNADA GKRGSFSLKQ 660 LKVATGDFDP SNKIGEGGFG SVYKGRLPDG TLIAVKMLSS KSRQGNKEFV NEIGMIACLQ 720 HPNLVKLYGC CCENNQLLLV YEYLENNCLA DALFGRSGLK LEWGTRHKIC LGIARGLAFL 780 HDDSAVKIIH RDIKGTNVLL DKDLNSKISD FGLARLHEDE ESHVTTRVAG TIGYMAPEYA 840 MRGHLTEKAD VYSFGVVAME IVSGKSNANY TPENECCVGL LDWAFVLQKK GDFAEIMYPR 900 LEGVFDVKEA ERMIKVSLLC SSKSPTLRPT MSEVVKMLEG ETQIEHIITD PGVYGDDLRF 960 KRSSEMGTSS LPSDYIIPSS CESSYDLYPL SPESIVFSRP * |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam00069 | Pkinase | 5.0e-49 | 673 | 936 | 269 | + Protein kinase domain. | ||
cd00192 | PTKc | 3.0e-49 | 672 | 939 | 287 | + Catalytic domain of Protein Tyrosine Kinases. Protein Tyrosine Kinase (PTK) family, catalytic domain. This PTKc family is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers. | ||
smart00219 | TyrKc | 1.0e-52 | 673 | 938 | 285 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
smart00221 | STYKc | 5.0e-53 | 673 | 938 | 285 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
pfam11721 | Malectin | 3.0e-55 | 403 | 590 | 190 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. |
Gene Ontology | |
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GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005515 | protein binding |
GO:0005524 | ATP binding |
GO:0006468 | protein phosphorylation |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAG10620.1 | 0 | 3 | 1000 | 1 | 940 | AC008030_20 Putative receptor-like serine/threonine kinase [Arabidopsis thaliana] |
GenBank | AAG10621.1 | 0 | 1 | 998 | 8 | 945 | AC008030_21 Putative receptor-like serine/threonine kinase [Arabidopsis thaliana] |
GenBank | AAG50774.1 | 0 | 1 | 995 | 8 | 968 | AC079288_3 receptor protein kinase, putative [Arabidopsis thaliana] |
RefSeq | NP_174266.2 | 0 | 1 | 998 | 8 | 967 | ATP binding / kinase/ protein binding / protein kinase/ protein serine/threonine kinase/ protein tyrosine kinase [Arabidopsis thaliana] |
RefSeq | NP_174267.4 | 0 | 1 | 995 | 8 | 1006 | kinase [Arabidopsis thaliana] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3ulz_A | 0 | 651 | 941 | 15 | 309 | A Chain A, Pectin Methylesterase From Carrot |
PDB | 3uim_A | 0 | 651 | 941 | 15 | 309 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
PDB | 3tl8_H | 0 | 651 | 941 | 23 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_G | 0 | 651 | 941 | 23 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_D | 0 | 651 | 941 | 23 | 317 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |