Basic Information | |
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Species | Thellungiella halophila |
Cazyme ID | Thhalv10011204m |
Family | CBM57 |
Protein Properties | Length: 1032 Molecular Weight: 114431 Isoelectric Point: 5.2007 |
Chromosome | Chromosome/Scaffold: 7 Start: 1088241 End: 1094613 |
Description | Leucine-rich repeat transmembrane protein kinase |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
CBM57 | 404 | 575 | 3.2e-22 |
INCGGRGIEIEKDTYVEDLNDGGPSRFFSVAEKWGYSSSGGWVGNGEAGYIATDRFNLINGSVPEYYKTGRLAPQSLKYYGLCMRSGRGTYKVQLHFAEI MFSNDQTYNSLGRRVFDIYVQGNLLERDFNIAERAGGVGKPFIRQIDEVQVNGSTLEIHLQWSGKGTNMIPT |
Full Sequence |
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Protein Sequence Length: 1032 Download |
MGFIFSAEKV MNALLFIVIF FQIYGLNAQL LPEDEVQTLR TIFRKLQNQT VNIERTSCSD 60 RNWNFASGLA NSTIICDCSI NATCHVTSVE LKGFSLPGIF PPEFGNLTRL QEIDLSRNYL 120 NGTIPTTLSR IPLAILSVIG NRLSGPIPPQ LGAITTLIDL NLEDNFLTGP LPSNLGNLRS 180 LQRLLLSANN FTGPIPESLS NLRNLTDFRI DGNSLSGKIP DFIGNWTLLD RLDLQGTSME 240 GPVPASISNL KNLTELRITD LDGPASTFPD LRNMTNMKRL VLRNCKIRGR IPDYISSMSG 300 LKLLDLSSNM LTGPIPDTFR SLDYDFMFLS NNSLTGQVPQ FILDSRERLD LSYNNFTQPP 360 SLSCNQIDLN LVSSYPSVTD NNVQWCLRDD LPCPRDAEHS SLFINCGGRG IEIEKDTYVE 420 DLNDGGPSRF FSVAEKWGYS SSGGWVGNGE AGYIATDRFN LINGSVPEYY KTGRLAPQSL 480 KYYGLCMRSG RGTYKVQLHF AEIMFSNDQT YNSLGRRVFD IYVQGNLLER DFNIAERAGG 540 VGKPFIRQID EVQVNGSTLE IHLQWSGKGT NMIPTRGVYG PLISAITITP NFKVDTGKPL 600 SNGAVAGIVV AACAVFALLV VIILRLTGYL GKKEDDENEE LRGLDLQTGS FTLKQIKRAT 660 NNFDPENKIG EGGFGPVYKG VLADGTTIAV KQLSSKSKQG NREFVTEIGM ISALQHPNLV 720 KLYGCCIEGK ELLLVYEYLE NNSLARALFG SEKQRLHLDW STRNKICIGI AKGLAYLHEE 780 SRLKIVHRDI KATNVLLDQS LNAKISDFGL AKLDEEENTH ISTRIAGTIG YMAPEYAMRG 840 YLTDKADVYS FGVVCLEIVS GKSNTNYRPK EEFVYLLDWA YVLQEQGNLL ELVDMDLGTS 900 FSKKEAKRML NIALLCTNPS PTLRPPMSSV VSMLEGKSKV QPPLVKREAD PSGAAAMRFK 960 AFELISQDSE SQVSTFERDR ENKSSSSMDA PWVDSSFSVQ DKDVKQEEDE EERSSSSSRK 1020 LLDDLNEVKI E* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam07714 | Pkinase_Tyr | 4.0e-42 | 668 | 934 | 286 | + Protein tyrosine kinase. | ||
cd00192 | PTKc | 5.0e-44 | 667 | 935 | 284 | + Catalytic domain of Protein Tyrosine Kinases. Protein Tyrosine Kinase (PTK) family, catalytic domain. This PTKc family is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers. | ||
smart00221 | STYKc | 7.0e-45 | 666 | 934 | 286 | + Protein kinase; unclassified specificity. Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase. | ||
smart00219 | TyrKc | 5.0e-46 | 666 | 934 | 280 | + Tyrosine kinase, catalytic domain. Phosphotransferases. Tyrosine-specific kinase subfamily. | ||
pfam11721 | Malectin | 3.0e-49 | 401 | 586 | 188 | + Di-glucose binding within endoplasmic reticulum. Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan. |
Gene Ontology | |
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GO Term | Description |
GO:0004672 | protein kinase activity |
GO:0005515 | protein binding |
GO:0005524 | ATP binding |
GO:0006468 | protein phosphorylation |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAF78445.1 | 0 | 1 | 1031 | 1 | 979 | AC018748_24 Contains a weak similarity to disease resistance protein (cf-5) gene from Lycopersicon esculentum gb |
Swiss-Prot | C0LGG8 | 0 | 1 | 1031 | 1 | 1038 | Y5343_ARATH RecName: Full=Probable LRR receptor-like serine/threonine-protein kinase At1g53430; Flags: Precursor |
RefSeq | NP_001117479.1 | 0 | 36 | 1031 | 3 | 997 | leucine-rich repeat family protein / protein kinase family protein [Arabidopsis thaliana] |
RefSeq | NP_175748.1 | 0 | 1 | 1031 | 1 | 1030 | leucine-rich repeat family protein / protein kinase family protein [Arabidopsis thaliana] |
RefSeq | NP_175749.1 | 0 | 1 | 1031 | 1 | 1035 | leucine-rich repeat family protein / protein kinase family protein [Arabidopsis thaliana] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3ulz_A | 0 | 647 | 936 | 16 | 308 | A Chain A, The Crystal Structure Of Rice (Oryza Sativa L.) Os4bglu12 |
PDB | 3uim_A | 0 | 647 | 936 | 16 | 308 | A Chain A, Structural Basis For The Impact Of Phosphorylation On Plant Receptor- Like Kinase Bak1 Activation |
PDB | 3tl8_H | 0 | 647 | 936 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_G | 0 | 647 | 936 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |
PDB | 3tl8_D | 0 | 647 | 936 | 24 | 316 | B Chain B, The Avrptob-Bak1 Complex Reveals Two Structurally Similar Kinaseinteracting Domains In A Single Type Iii Effector |