| Basic Information | |
|---|---|
| Species | Thellungiella halophila |
| Cazyme ID | Thhalv10012727m |
| Family | GH89 |
| Protein Properties | Length: 794 Molecular Weight: 91814.4 Isoelectric Point: 8.2679 |
| Chromosome | Chromosome/Scaffold: 2 Start: 4481386 End: 4486102 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| External Links |
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| CAZyDB |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 93 | 789 | 0 |
| PEIVIKGTTGVEIASGLHWYLKYKCNAHVSWDKTGGIQIASVPHPGHLPRLDSKRILIRRPVPWNYYQNVVTSSYSYVWWGWERWEREIDWMALQGINLP LAFTGQEAIWQKVFKRFNITKEDLDDYFGGPAFLAWARMGNLHAWGGPLSENWLGDQLLLQKQLLSRMLELGMTPVLPSFSGNVPSALRKIYPAANIARL DDWNTVDGDSRWCCTYLLNPSDPLFIDIGEAFIKQQIEEYGDITNIYNCDTFNENTPPTNEPEYISSLGSAVYKAMSKGNKNAVWLMQGWLFSSDSKFWK PPQMKALLHSVPFGKMIVLDLFADVKPIWNTSAQFYATPYIWCMLHNFGGNIEMYGTLDSPSKVGVGMCMEGIEHNPVVYELMSEMAFRDEKVDVQKWLK SYARRRYMKENHHIEAAWEILYHTVYNCTDGIADHNTDFIVKLPDWDPSSSVQGETKKTDPYMISTDPYETKRRFLFQDDSSGLPKAHLWYSTKEVIKAL QLFLEAGDDLFGSLTYRYDMVDLTRQVLSKLANKVYIEAVTAFVKKDIGSLRRLSKKFLELIKDIDVLLASDDNFLLGTWLESAKKLARNDDERKQYEWN ARTQVTMWYDSKDVNQSKLHDYANKFWSGLLEDYYLPRAKLYFNELLKSLRDKKKLEIEKWRREWIMKSHKWQQSSSEVYQVKAKGDALAISRHLLR | |||
| Full Sequence |
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| Protein Sequence Length: 794 Download |
| MRPIKLFMLV LLILSLHSQS FSKQHPTIDR LLLNLDSLRP TPSVQVSAAK GLLQRLIPTH 60 FHSFDFSIIS KDVCGGSSCF LIENYDGPRR IGPEIVIKGT TGVEIASGLH WYLKYKCNAH 120 VSWDKTGGIQ IASVPHPGHL PRLDSKRILI RRPVPWNYYQ NVVTSSYSYV WWGWERWERE 180 IDWMALQGIN LPLAFTGQEA IWQKVFKRFN ITKEDLDDYF GGPAFLAWAR MGNLHAWGGP 240 LSENWLGDQL LLQKQLLSRM LELGMTPVLP SFSGNVPSAL RKIYPAANIA RLDDWNTVDG 300 DSRWCCTYLL NPSDPLFIDI GEAFIKQQIE EYGDITNIYN CDTFNENTPP TNEPEYISSL 360 GSAVYKAMSK GNKNAVWLMQ GWLFSSDSKF WKPPQMKALL HSVPFGKMIV LDLFADVKPI 420 WNTSAQFYAT PYIWCMLHNF GGNIEMYGTL DSPSKVGVGM CMEGIEHNPV VYELMSEMAF 480 RDEKVDVQKW LKSYARRRYM KENHHIEAAW EILYHTVYNC TDGIADHNTD FIVKLPDWDP 540 SSSVQGETKK TDPYMISTDP YETKRRFLFQ DDSSGLPKAH LWYSTKEVIK ALQLFLEAGD 600 DLFGSLTYRY DMVDLTRQVL SKLANKVYIE AVTAFVKKDI GSLRRLSKKF LELIKDIDVL 660 LASDDNFLLG TWLESAKKLA RNDDERKQYE WNARTQVTMW YDSKDVNQSK LHDYANKFWS 720 GLLEDYYLPR AKLYFNELLK SLRDKKKLEI EKWRREWIMK SHKWQQSSSE VYQVKAKGDA 780 LAISRHLLRK YFT* |
| Functional Domains Download unfiltered results here | ||||||||
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 4.0e-23 | 45 | 143 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 2.0e-106 | 489 | 791 | 303 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 6.0e-164 | 158 | 484 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 5 | 792 | 68 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 41 | 792 | 52 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| RefSeq | NP_196873.1 | 0 | 1 | 792 | 1 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 5 | 793 | 3 | 803 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 27 | 792 | 28 | 805 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 13 | 782 | 139 | 867 | A Chain A, The Structure Of Bluetongue Virus Vp4 Reveals A Multifunctional Rna-capping Production-line |
| PDB | 2vcb_A | 0 | 13 | 782 | 139 | 867 | A Chain A, The Structure Of Bluetongue Virus Vp4 Reveals A Multifunctional Rna-capping Production-line |
| PDB | 2vca_A | 0 | 13 | 782 | 139 | 867 | A Chain A, The Structure Of Bluetongue Virus Vp4 Reveals A Multifunctional Rna-capping Production-line |
| PDB | 2vc9_A | 0 | 13 | 782 | 139 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 13 | 782 | 162 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
