Basic Information | |
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Species | Thellungiella halophila |
Cazyme ID | Thhalv10013133m |
Family | GT68 |
Protein Properties | Length: 564 Molecular Weight: 63869.7 Isoelectric Point: 7.2666 |
Chromosome | Chromosome/Scaffold: 2 Start: 15577265 End: 15579254 |
Description | O-fucosyltransferase family protein |
View CDS |
External Links |
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CAZyDB |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT68 | 243 | 539 | 0 |
DRVLVIPSSKFDYQYDRVIDIDRINTCLGRNVVVSFDQFKEKAKKNRPRIDRFICYFSSPQLCYVDEEHIKKLKSLGISIDGKLDSPWSEDIKKPSKKTM EEVKRSFKSDDDVIAIGDVFYADMEQDLVMQPGGPINHNCKTLIEPSKLILLTAQRFIQTFLGKNFIALHFRRHGFLKFCNAKKPSCFYPIPQAAECIAR IVERSNGAVIYLSTDAAESETSLLQSLVVVNGKIVPFVKRPPRNSAEKWDALLYRHGIEDDSQVDAMLDKTICAMSSVFIGASGSTFTEDILRLRKD |
Full Sequence |
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Protein Sequence Length: 564 Download |
MERNSSDDEE DHQHLIPQND TRNRHREDPL SSTVTTGGTP RSAFQIEDIL SRRKISLNKR 60 YILAAVSLTI SIGLVFLITD PPRLFSANFS SFKVDPMSSR VKESQLRALY LLRQQQLAIL 120 SLWNGTLVNP SPNHQSANAN GSSVLFEDVK SAVSKQISLN KEIQEVLLAP HRTGNYSGNE 180 SESDSGDYSY NRCRKVDQNL SDRKTIEWNP RSDKFLFAIC LSGQMSNHLI CLEKHMFFAA 240 LLDRVLVIPS SKFDYQYDRV IDIDRINTCL GRNVVVSFDQ FKEKAKKNRP RIDRFICYFS 300 SPQLCYVDEE HIKKLKSLGI SIDGKLDSPW SEDIKKPSKK TMEEVKRSFK SDDDVIAIGD 360 VFYADMEQDL VMQPGGPINH NCKTLIEPSK LILLTAQRFI QTFLGKNFIA LHFRRHGFLK 420 FCNAKKPSCF YPIPQAAECI ARIVERSNGA VIYLSTDAAE SETSLLQSLV VVNGKIVPFV 480 KRPPRNSAEK WDALLYRHGI EDDSQVDAML DKTICAMSSV FIGASGSTFT EDILRLRKDW 540 GTSSMCDEYL CRGEEPNFIA EDE* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
cd11296 | O-FucT_like | 0.0005 | 215 | 249 | 35 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
pfam10250 | O-FucT | 0.0002 | 238 | 530 | 325 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
cd11548 | NodZ_like | 4.0e-6 | 344 | 538 | 195 | + Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ. Bradyrhizobium NodZ is an alpha 1,6-fucosyltransferase involved in the biosynthesis of the nodulation factor, a lipo-chitooligosaccharide formed by three-to-six beta-1,4-linked N-acetyl-d-glucosamine (GlcNAc) residues and a fatty acid acyl group attached to the nitrogen atom at the non-reducing end. NodZ transfers L-fucose from the GDP-beta-L-fucose donor to the reducing residue of the chitin oligosaccharide backbone, before the attachment of a fatty acid group. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11298 | O-FucT-2 | 4.0e-10 | 404 | 530 | 127 | + GDP-fucose protein O-fucosyltransferase 2. O-FucT-2 adds O-fucose to thrombospondin type 1 repeats (TSRs), and appears conserved in bilateria. The O-fucosylation of TSRs appears to play a role in regulating secretion of metalloproteases of the ADAMTS superfamily. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
cd11296 | O-FucT_like | 5.0e-18 | 370 | 537 | 179 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
GenBank | AAD50008.1 | 0 | 1 | 563 | 1 | 594 | AC007651_3 Hypothetical Protein [Arabidopsis thaliana] |
GenBank | AAM66093.1 | 0 | 1 | 563 | 1 | 566 | unknown [Arabidopsis thaliana] |
RefSeq | NP_173170.2 | 0 | 1 | 563 | 1 | 564 | unknown protein [Arabidopsis thaliana] |
RefSeq | NP_199853.1 | 0 | 1 | 563 | 1 | 566 | unknown protein [Arabidopsis thaliana] |
RefSeq | XP_002264087.1 | 0 | 1 | 563 | 1 | 559 | PREDICTED: hypothetical protein [Vitis vinifera] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 4ap6_D | 0.01 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
PDB | 4ap6_C | 0.01 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
PDB | 4ap6_B | 0.01 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |
PDB | 4ap6_A | 0.01 | 404 | 530 | 277 | 383 | A Chain A, Crystal Structure Of Human Pofut2 E54a Mutant In Complex With Gdp- Fucose |