| Basic Information | |
|---|---|
| Species | Volvox carteri |
| Cazyme ID | Vocar20011583m |
| Family | GT47 |
| Protein Properties | Length: 601 Molecular Weight: 68082.2 Isoelectric Point: 8.3652 |
| Chromosome | Chromosome/Scaffold: 5 Start: 2037820 End: 2043863 |
| Description | Exostosin family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 161 | 466 | 3.1e-36 |
| TGVKVYIYELPSNMTSWYPFMRMDRPVHLMFWQRLMSSGMRTLDGNKADYFYIPINTRTGSLAREELEWTLPYIKKTYPWWSKDNGNRHLIIHTGDMGIN DFPLATRRELNESLSNITWLTHWGLHEYHPIAKWYPAHRPGKDIVIPVMIMTQGFHLSPMNPRMEAEIKAQGAPRLRNGTLFFAGRICGDRDLPDPKTGK CGPGHEDYSFGVRQAVYLQHRNVKGFRIVAWTSTYLEDISSHKFCLAPVGGGHGKRNILVAFMGCLPVLIGDHVLQPFEPEIDWSRFSISVPEADIPDLP RILANV | |||
| Full Sequence |
|---|
| Protein Sequence Length: 601 Download |
| MSWASIAIVT GLLFLAATPS EAFYRDDCYN STRGEERELC LRRSLLRRQA VAAPSSSCPK 60 GCTVHGVCHE DIGRCDCPRH FTGPACSTVV PSISKLCAKY SIKLRDFGKD SPCFNNCNQR 120 GRCIAGICHC QPGYWGIDCA ISWGPNGKMQ LLDGNYVERK TGVKVYIYEL PSNMTSWYPF 180 MRMDRPVHLM FWQRLMSSGM RTLDGNKADY FYIPINTRTG SLAREELEWT LPYIKKTYPW 240 WSKDNGNRHL IIHTGDMGIN DFPLATRREL NESLSNITWL THWGLHEYHP IAKWYPAHRP 300 GKDIVIPVMI MTQGFHLSPM NPRMEAEIKA QGAPRLRNGT LFFAGRICGD RDLPDPKTGK 360 CGPGHEDYSF GVRQAVYLQH RNVKGFRIVA WTSTYLEDIS SHKFCLAPVG GGHGKRNILV 420 AFMGCLPVLI GDHVLQPFEP EIDWSRFSIS VPEADIPDLP RILANVPASE VASKQKRLRC 480 AAQHMFYSST LGAILGEDGR YDAFETLMEI LRVRKEHPDV PPEKYQKVDQ RFRKFINCDL 540 DDEVNPVPLC TQGKEMQLVD RKSCKDCRRK DGTSNSFFNS AGGMLCCEDH DMTKCPRGWK 600 * 660 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 6.0e-34 | 159 | 466 | 331 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | XP_001693540.1 | 0 | 58 | 529 | 5 | 487 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
| RefSeq | XP_001702517.1 | 0 | 62 | 513 | 15 | 479 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
| RefSeq | XP_001702686.1 | 0 | 44 | 584 | 59 | 601 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
| RefSeq | XP_001703124.1 | 0 | 74 | 538 | 9 | 471 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
| RefSeq | XP_001703125.1 | 0 | 56 | 513 | 65 | 497 | exostosin-like glycosyltransferase [Chlamydomonas reinhardtii] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 4k0v_A | 0.003 | 41 | 143 | 181 | 271 | A Chain A, Structural Basis For Angiopoietin-1 Mediated Signaling Initiation |
| PDB | 2gy7_B | 0.005 | 41 | 143 | 181 | 271 | A Chain A, Angiopoietin-2TIE2 COMPLEX CRYSTAL STRUCTURE |
| PDB | 2gy5_A | 0.005 | 41 | 143 | 181 | 271 | A Chain A, Tie2 Ligand-Binding Domain Crystal Structure |
