| Basic Information | |
|---|---|
| Species | Volvox carteri |
| Cazyme ID | Vocar20012786m |
| Family | GT24 |
| Protein Properties | Length: 1931 Molecular Weight: 207355 Isoelectric Point: 5.0457 |
| Chromosome | Chromosome/Scaffold: 3 Start: 4235630 End: 4258581 |
| Description | UDP-glucose:glycoprotein glucosyltransferases;transferases, transferring hexosyl groups;transferases, transferring glycosyl groups |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT24 | 1573 | 1791 | 0 |
| INVFTVASGHMYERLQKIMILSVLRHTKSRVKFWIIKNYMSPQHKQVIPAMAEQFGFDYEFVTYKWPHWLHKQTDKQRLIWAYKILFLDVLFPLGVDRII FVDSDQVVHADLAELYHKDIKGAPYAYTPFCDNNKEMDEYRFWKGGFWRDHLQGKPYHISALYLVDLKRFRQIAAGDQLRVLYDQLSKDPNSLANLDQDL PNYAQHSIRIFSLPQVWCG | |||
| Full Sequence |
|---|
| Protein Sequence Length: 1931 Download |
| MACTWLKGDG KGRQGAQCAS GSTLYHILWQ SAATDKARQR YGGFDPDYIL FNRPCYSTRS 60 TFGLTVFLCQ RRLYGILAAM APNPSGHAII RISSAEEDAA LIWPFLDRMS SLSPDATGTD 120 LDDAACWRSI TETAAELVSP SVGKLIPLTL GSRQYGAKLQ MVRQLAEQFH PHEVSTATAS 180 CCFVALEGQV ATTPQQLADL LTSSSSSPSS SLSTSSSSTN PDSEQLFSFE HIYRGKATGS 240 LGGAETSRVA ILYGSPGLPC FGPLYEQLKT AVDEQSVGDG SGGGNGLMFA FRPLLTTTCE 300 PLSGCARAGT GGQLLLPGWG VEAALKNTEY SAMDDKEVAR QRQQQQQQGG TEGSGDDEEG 360 AAEEADFGSG DDAVVKGFRL DVLAARRPDL RSELLTFRDQ LLAADDEESA ELKVWDLRDV 420 GLQATQRILG SSDPLALLAE ISQNFPGIVS SLSRQVVSSS LKNAVTHNQQ MVSAGANFLL 480 LNGLAVDVNN LDFFGFLSRL RSEMRLRDSL VGAPLELSPN LAKQVLAARA EDGAAAGAGG 540 GGAGGEGEPR LSLGSTSSAM SKHVAFLNDL ERDPRFQRFG RNLAELLNTF PGRLRPLARN 600 VFTSVVVVEP LCSESLELVA NIDRMWQGGY PIRFGGERFG RGFATLKEAF GPAAAWRMWI 660 DAAEAVTSGY YSDPQEVVEA AFTSAWGAAA RSPPPGTRAK TAARKSTSDA LKMLKEGSGY 720 AAEVGMQLME TASWLMIKGL VAPPPAAAVA AAATPAADRD EDAERCTAPP VVWMNGLTAK 780 AGGSSPAEDI MYKVMGEMQR LQEAIYFGRM DDNSGGGDAL AAVLEMFGAV ERLNQRIVGP 840 KARNAQVLNL VPLLRHPAHE TLRMLYRESG SEDGDGTPYV APVTHYVAAD LANEEGRQLV 900 AESLRLLSEV LPSSSSRDCR LVLVANPSQP AAAPSLLEAL VEGGMRQLES GGRDKPLAPL 960 HSTHPGSHFP ISTSSNMHGL DVVSYLSRLM SDSALAAGSG GEAAGGGGEV EEQTQEAIKY 1020 AEEAGLDGEA IKSFLAKAVD ESLTYRAVQA DLCRTVFKLE PGAAAVISNG RVTPVYKPSE 1080 EHSLPNIFVP TKPSFQIHLE LLAEDLSLLQ RVTSGGMAGS VAKAVERAYS EGLQRLPADL 1140 PSGVSASDAL SEISSTVVSA LSAASRAAAS AGSQEGSGGA SRLGPGASLQ LQQMMAMLKR 1200 KAVEVSGGPD PPFHLEAVLN PLSRSAQRLT SLLLVLREAL GPSMSLTLNP QKDITEMPLK 1260 SYYRRVQEAG LGGQGGKLRG AARVYALPSG LAPGSGPPGP PTAYFSRLPA RRVLTLNLDA 1320 PEAWLVEPAA ALYDLDNLRL EDVAGEVAFA EFELDALMLT GSCVDVTASG RMTPPRGLQL 1380 HLGTPTQPHT VDTLVMANLA YFQLKAAPGR WLLSLAPGRS RDLYLLQSST GTSRDVFAEE 1440 EEGSGEAERV AGALVRTGGG GGGDDVSTQV LISSFMGKHM ILRVRKRPGM EAEDVLQADG 1500 TADDAYDTWD PDLEDDEYAD DDDDKAPPAP SSGGLLGKVS SLLSGSAKGG SGGAGGELAA 1560 SKKQRQLRGG DTINVFTVAS GHMYERLQKI MILSVLRHTK SRVKFWIIKN YMSPQHKQVI 1620 PAMAEQFGFD YEFVTYKWPH WLHKQTDKQR LIWAYKILFL DVLFPLGVDR IIFVDSDQVV 1680 HADLAELYHK DIKGAPYAYT PFCDNNKEMD EYRFWKGGFW RDHLQGKPYH ISALYLVDLK 1740 RFRQIAAGDQ LRVLYDQLSK DPNSLANLDQ DLPNYAQHSI RIFSLPQVWC GVVWVGDFGA 1800 GFRNRDVMGM CEEWLWCESW CGNVTKAKAK TIDLCNNPKT KEPKLTAARR IIGPLWEELD 1860 RQQEEVTRMV QSMLEAREEA GPPGSALPPP QPPAVGEPAG HGQEEEGLDM SWEAADQRHE 1920 SHHASDRTEL * 1980 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam01501 | Glyco_transf_8 | 1.0e-7 | 1592 | 1790 | 208 | + Glycosyl transferase family 8. This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase. | ||
| cd04194 | GT8_A4GalT_like | 1.0e-16 | 1590 | 1790 | 205 | + A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS. | ||
| cd00505 | Glyco_transf_8 | 9.0e-50 | 1573 | 1839 | 276 | + Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+. | ||
| pfam06427 | UDP-g_GGTase | 7.0e-50 | 1210 | 1398 | 189 | + UDP-glucose:Glycoprotein Glucosyltransferase. The N-terminal region of this group of proteins is required for correct folding of the ER UDP-Glc: glucosyltransferase. | ||
| cd06432 | GT8_HUGT1_C_like | 5.0e-160 | 1573 | 1845 | 273 | + The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family. C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0003980 | UDP-glucose:glycoprotein glucosyltransferase activity |
| GO:0006486 | protein glycosylation |
| GO:0016757 | transferase activity, transferring glycosyl groups |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAD28382.1 | 0 | 101 | 1893 | 68 | 1614 | putative UDP-glucose:glycoprotein glucosyltransferase [Oryza sativa Japonica Group] |
| GenBank | EEE57527.1 | 0 | 130 | 1893 | 63 | 1585 | hypothetical protein OsJ_07839 [Oryza sativa Japonica Group] |
| RefSeq | NP_001071002.1 | 0 | 95 | 1878 | 46 | 1502 | UDP-glucose ceramide glucosyltransferase-like 1 [Danio rerio] |
| RefSeq | XP_002268972.1 | 0 | 96 | 1889 | 59 | 1594 | PREDICTED: similar to EBS1 (EMS-MUTAGENIZED BRI1 SUPPRESSOR 1); UDP-glucose:glycoprotein glucosyltransferase/ transferase, transferring glycosyl groups / transferase, transferring hexosyl groups [Vitis vinifera] |
| RefSeq | XP_002529534.1 | 0 | 95 | 1770 | 58 | 1499 | UDP-glucose glycoprotein:glucosyltransferase, putative [Ricinus communis] |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| GO883503 | 303 | 1568 | 1870 | 0 |
| GT619641 | 281 | 1565 | 1845 | 0 |
| HO475103 | 304 | 1569 | 1872 | 0 |
| DR944618 | 300 | 1568 | 1867 | 0 |
| GW770311 | 293 | 1568 | 1860 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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