| Basic Information | |
|---|---|
| Species | Volvox carteri |
| Cazyme ID | Vocar20012894m |
| Family | GH18 |
| Protein Properties | Length: 857 Molecular Weight: 89173.8 Isoelectric Point: 7.9199 |
| Chromosome | Chromosome/Scaffold: 3 Start: 3848358 End: 3856167 |
| Description | Glycosyl hydrolase family protein with chitinase insertion domain |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH18 | 37 | 362 | 0 |
| LYVPGWAENTGSVLNFFNTSAINLEGVSHVYYAFLWIYGGNSTVYDPFGNLKLLVSLKSRWPATKLILSIGGGGFSTTIWTKAATTGLTAFVNSAIKAMK SANADGIDLDWEYPVASTRDTFTALCAAMRLRLDAEGAAATPARHYWLTAATQSIVSGDSFDGYDLPVLKNHLDLFNIMTYTMHDPCFWETETHFHTAWA ECATALDYYLSKGVPRTQLVLGLAFYGHVYRLTDPSVYKYPAPSVEGRDCSTMTTVSYRAILLELKNSNGRGGVFVDVAQRSAYFVYDTRWIGFDIPETM ALKINASRAYGVGGVMIWDASLDTPD | |||
| Full Sequence |
|---|
| Protein Sequence Length: 857 Download |
| MRSPWLPSLL ALVYCSVLTH RAYAGLATTA PDSVTGLYVP GWAENTGSVL NFFNTSAINL 60 EGVSHVYYAF LWIYGGNSTV YDPFGNLKLL VSLKSRWPAT KLILSIGGGG FSTTIWTKAA 120 TTGLTAFVNS AIKAMKSANA DGIDLDWEYP VASTRDTFTA LCAAMRLRLD AEGAAATPAR 180 HYWLTAATQS IVSGDSFDGY DLPVLKNHLD LFNIMTYTMH DPCFWETETH FHTAWAECAT 240 ALDYYLSKGV PRTQLVLGLA FYGHVYRLTD PSVYKYPAPS VEGRDCSTMT TVSYRAILLE 300 LKNSNGRGGV FVDVAQRSAY FVYDTRWIGF DIPETMALKI NASRAYGVGG VMIWDASLDT 360 PDGSLLRAVA SRNMSTTRPC GGGFVGNGAC GDASLCCSEF GYCGLGETFC GPKCRGGPCI 420 QYPSPPPRPP APPPNCGNGV VGGGVCAVIS ECCSVAGWCG TGEAWCGVNC VGGPCWYKPR 480 SPPPPPRPPP KPSPPPPPPL SYGCGEGIIG NGTCPFPYEC CSAFGYCGTS DAHCGYGCQG 540 GPCTPFPPPP PGDIGPTCGN GNVGNGRCGF PGDCCSKFGY CGNTVDHCGP GSCTGGACWV 600 PPPPPPGGTN NDKPPPPYPS PKQPPPSAKP PPPSSPKPPP PSSPKPPPPS SPKPPPPSSP 660 KPPPPPSPKP PPPPSPKPPP PPPSPKPPSP KPPPPSPKPP SPTPPGATRS PPPPPLLPPP 720 RPSASTFCGN GKVGNGTCRD PTQCCSAAGF CAVSADHCYW YCVGGPCWVP PPPPPAPPGM 780 LASPSPPPPN PPGVVTVYCG DGVVGNKQCR LKNLCCSAAG FCAYSADHCL HYCVGGPCWA 840 PPPSAVQKMM NATSSP* 900 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| COG3325 | ChiA | 9.0e-30 | 23 | 370 | 420 | + Chitinase [Carbohydrate transport and metabolism] | ||
| cd06548 | GH18_chitinase | 9.0e-46 | 38 | 359 | 368 | + The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. | ||
| cd02872 | GH18_chitolectin_chitotriosidase | 4.0e-48 | 65 | 362 | 330 | + This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens. | ||
| pfam00704 | Glyco_hydro_18 | 4.0e-51 | 38 | 359 | 338 | + Glycosyl hydrolases family 18. | ||
| smart00636 | Glyco_18 | 2.0e-54 | 38 | 359 | 351 | + Glyco_18 domain. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| DDBJ | BAA13974.1 | 6e-33 | 38 | 385 | 51 | 384 | chitinase C [Bacillus circulans] |
| RefSeq | XP_001230002.1 | 3e-28 | 58 | 389 | 218 | 547 | hypothetical protein CHGG_03486 [Chaetomium globosum CBS 148.51] |
| RefSeq | XP_001230002.1 | 0.0003 | 396 | 548 | 76 | 185 | hypothetical protein CHGG_03486 [Chaetomium globosum CBS 148.51] |
| RefSeq | XP_396925.3 | 2e-27 | 64 | 365 | 110 | 431 | PREDICTED: similar to CG1869-PA [Apis mellifera] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 1wb0_A | 8e-26 | 64 | 359 | 31 | 342 | A Chain A, Galactose Oxidase W290g Mutant |
| PDB | 1waw_A | 8e-26 | 64 | 359 | 31 | 342 | A Chain A, Specificity And Affinity Of Natural Product Cyclopentapeptide Inhibitor Argadin Against Human Chitinase |
| PDB | 1hkm_A | 2e-23 | 64 | 359 | 31 | 342 | A Chain A, Specificity And Affinity Of Natural Product Cyclopentapeptide Inhibitor Argadin Against Human Chitinase |
| PDB | 1hkj_A | 2e-23 | 64 | 359 | 31 | 342 | A Chain A, Specificity And Affinity Of Natural Product Cyclopentapeptide Inhibitor Argadin Against Human Chitinase |
| PDB | 1hki_A | 2e-23 | 64 | 359 | 31 | 342 | A Chain A, Crystal Structure Of Human Chitinase In Complex With Glucoallosamidin B |
