| Basic Information | |
|---|---|
| Species | Volvox carteri |
| Cazyme ID | Vocar20013933m |
| Family | AA3 |
| Protein Properties | Length: 614 Molecular Weight: 65233.3 Isoelectric Point: 8.6656 |
| Chromosome | Chromosome/Scaffold: 6 Start: 2810841 End: 2816729 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 44 | 603 | 0 |
| GSEKFDYILVGGGTAGCVLANKLSANGSKKVLVLEAGPTGDAMEVAVPAGIARLFAHPVFDWGMSSLTQQQLVAREIYLARGRLLGGSSGTNATLYHRGT PADYDSWGLEGWTSKDLLDWFVKAECYGDGPRAFHGQSGSMNVEQPRYQNVLHDEFFRAAAAAGLPANEDFNDWSRPQEGYGEFQVAQKNGERADTYRTY LKPAMGRDNLKVMTGARTTKVHIEKSSTGPRARGVEYATQQFGERYTAELTPGGEVLMCTGAVHTPHLLMLSGIGPAPTLLEHGLDVISSLPGVGANLQD HPAAVLAVRAKPEFEGLSVTSEIYDSKCNIRLGAVMKYLFGRRGPLATTGCDHGAFVRTSASHSQPDLQMRFVPGCALDPDGVKSYIVFGELKKQGRAWP GGITLQLLGIRAKSRGSIGLKAADPFINPAININYFSDPEDLATLKNGVRIAREIVAQEPLRKYLLEETFPGERANTDKDIEEYVRRTVHSGNALVGTCA MGTTPASGAVVSSADLKVFGVDGLRVVDASVLPRIPGGQTGAATVMVAERAAAMLLGQAT | |||
| Full Sequence |
|---|
| Protein Sequence Length: 614 Download |
| MLLGQRPFGA PAKGAMPCWK AARHGGVAGV ARRPVAVKAA ASVGSEKFDY ILVGGGTAGC 60 VLANKLSANG SKKVLVLEAG PTGDAMEVAV PAGIARLFAH PVFDWGMSSL TQQQLVAREI 120 YLARGRLLGG SSGTNATLYH RGTPADYDSW GLEGWTSKDL LDWFVKAECY GDGPRAFHGQ 180 SGSMNVEQPR YQNVLHDEFF RAAAAAGLPA NEDFNDWSRP QEGYGEFQVA QKNGERADTY 240 RTYLKPAMGR DNLKVMTGAR TTKVHIEKSS TGPRARGVEY ATQQFGERYT AELTPGGEVL 300 MCTGAVHTPH LLMLSGIGPA PTLLEHGLDV ISSLPGVGAN LQDHPAAVLA VRAKPEFEGL 360 SVTSEIYDSK CNIRLGAVMK YLFGRRGPLA TTGCDHGAFV RTSASHSQPD LQMRFVPGCA 420 LDPDGVKSYI VFGELKKQGR AWPGGITLQL LGIRAKSRGS IGLKAADPFI NPAININYFS 480 DPEDLATLKN GVRIAREIVA QEPLRKYLLE ETFPGERANT DKDIEEYVRR TVHSGNALVG 540 TCAMGTTPAS GAVVSSADLK VFGVDGLRVV DASVLPRIPG GQTGAATVMV AERAAAMLLG 600 QATITSRREP AAV* 660 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| TIGR03970 | Rv0697 | 7.0e-14 | 439 | 579 | 142 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
| TIGR03970 | Rv0697 | 6.0e-40 | 49 | 356 | 321 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
| TIGR01810 | betA | 3.0e-94 | 49 | 581 | 539 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 1.0e-112 | 45 | 583 | 547 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PRK02106 | PRK02106 | 2.0e-126 | 45 | 581 | 548 | + choline dehydrogenase; Validated | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | AAX23098.1 | 0 | 43 | 605 | 8 | 550 | alcohol dehydrogenase [Alcanivorax borkumensis SK2] |
| RefSeq | XP_001703004.1 | 0 | 1 | 613 | 1 | 611 | predicted protein [Chlamydomonas reinhardtii] |
| RefSeq | XP_002178042.1 | 0 | 48 | 598 | 1 | 539 | predicted protein [Phaeodactylum tricornutum CCAP 1055/1] |
| RefSeq | YP_002297804.1 | 0 | 48 | 604 | 2 | 531 | alcohol dehydrogenase (acceptor) [Rhodospirillum centenum SW] |
| RefSeq | YP_691922.1 | 0 | 46 | 605 | 4 | 543 | alcohol degydrogenase [Alcanivorax borkumensis SK2] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fim_B | 0 | 47 | 598 | 2 | 562 | B Chain B, Crystal Structure Of Aryl-Alcohol-Oxidase From Pleurotus Eryingii |
| PDB | 3ljp_B | 0 | 37 | 598 | 3 | 526 | A Chain A, Crystal Structure Of Choline Oxidase V464a Mutant |
| PDB | 3ljp_A | 0 | 37 | 598 | 3 | 526 | A Chain A, Crystal Structure Of Choline Oxidase V464a Mutant |
| PDB | 3nne_H | 0 | 37 | 598 | 3 | 526 | A Chain A, Crystal Structure Of Choline Oxidase S101a Mutant |
| PDB | 3nne_G | 0 | 37 | 598 | 3 | 526 | A Chain A, Crystal Structure Of Choline Oxidase S101a Mutant |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| FD836615 | 268 | 109 | 376 | 0 |
| FD835421 | 246 | 190 | 435 | 0 |
| FD820451 | 231 | 258 | 488 | 0 |
| BI724929 | 218 | 265 | 482 | 0 |
| FD801643 | 220 | 1 | 220 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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