| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_001859m |
| Family | GH89 |
| Protein Properties | Length: 809 Molecular Weight: 92418.3 Isoelectric Point: 6.6583 |
| Chromosome | Chromosome/Scaffold: 06659 Start: 268488 End: 278299 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH89 | 96 | 804 | 0 |
| GPEIIIKGTTAVELASGLHWYIKYWCGAHISWDKTGGIQINSIPKPGSLPLVKDEGVVIQRPVPWNYYQNVVTSSYSYVWWNWERWEKEIDWMALQGINL PLAFTGQEAIWQKVFMNLNVSSEDLNDFFGGPAFLAWARMGNLHAWGGPLSQNWLDQQLSLQKQILSRMLELGMTPVLPSFSGNVPAALKKIFPSANITR LGDWNTVNKNPRWCCTYLLDPSDPLFVEIGEAFIRQQIKEYGDVTDIYNCDTFNENIPPTNDSDYISSLGAAVYKAMSKGDEDAVWLMQGWLFYSDSSFW KPPQMKALLHSVPFGKMIVLDLFADVKPIWRTSSQFYGTPYVWCMLHNFGGNIEMYGILDAISSGPIDAHISENSTMVGVGMCMEGIEHNPVVYELMSEM AFRSEKVRVLEWLRNYSRRRYGKAVNQVEAAWEILYRTIYNCTDGIADHNRDFIVKFPDWDPSLNSGSDTSKEDTKHIFLSLPRTRRFLFQQSSSKLPQA HLWYSTQEVVNALQLFLDAGNDLNRSLTYRYDLVDLTRQVLSKLANQVYIDAIIAFQRKDADALNLHSQKFLQLINDIDVLLASDDNFLLGTWLESAKEL GVNPVEMKQYEWNARTQVTMWYDTTKTNQSQLHDYANKFWSGLLKDYYLPRASTYFDHLAKSLKENENFNIVGWREEWIAFSNKWQVSTELYPVKARGDA LAISKALYK | |||
| Full Sequence |
|---|
| Protein Sequence Length: 809 Download |
| MSNLPLSTSK FTAILLLFLL PVALSASRHE AIDAVLNRLD SKRSSPSVQE SAAKGVLRRL 60 LPSHLHSFEF KIVSKDVCGG HSCFLIKNYN KSSQNGPEII IKGTTAVELA SGLHWYIKYW 120 CGAHISWDKT GGIQINSIPK PGSLPLVKDE GVVIQRPVPW NYYQNVVTSS YSYVWWNWER 180 WEKEIDWMAL QGINLPLAFT GQEAIWQKVF MNLNVSSEDL NDFFGGPAFL AWARMGNLHA 240 WGGPLSQNWL DQQLSLQKQI LSRMLELGMT PVLPSFSGNV PAALKKIFPS ANITRLGDWN 300 TVNKNPRWCC TYLLDPSDPL FVEIGEAFIR QQIKEYGDVT DIYNCDTFNE NIPPTNDSDY 360 ISSLGAAVYK AMSKGDEDAV WLMQGWLFYS DSSFWKPPQM KALLHSVPFG KMIVLDLFAD 420 VKPIWRTSSQ FYGTPYVWCM LHNFGGNIEM YGILDAISSG PIDAHISENS TMVGVGMCME 480 GIEHNPVVYE LMSEMAFRSE KVRVLEWLRN YSRRRYGKAV NQVEAAWEIL YRTIYNCTDG 540 IADHNRDFIV KFPDWDPSLN SGSDTSKEDT KHIFLSLPRT RRFLFQQSSS KLPQAHLWYS 600 TQEVVNALQL FLDAGNDLNR SLTYRYDLVD LTRQVLSKLA NQVYIDAIIA FQRKDADALN 660 LHSQKFLQLI NDIDVLLASD DNFLLGTWLE SAKELGVNPV EMKQYEWNAR TQVTMWYDTT 720 KTNQSQLHDY ANKFWSGLLK DYYLPRASTY FDHLAKSLKE NENFNIVGWR EEWIAFSNKW 780 QVSTELYPVK ARGDALAISK ALYKRYFG* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12971 | NAGLU_N | 4.0e-24 | 49 | 147 | 99 | + Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold. | ||
| pfam12972 | NAGLU_C | 3.0e-107 | 506 | 806 | 301 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 0 | 162 | 501 | 340 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAA77084.1 | 0 | 13 | 807 | 11 | 810 | alpha-N-acetylglucosaminidase [Nicotiana tabacum] |
| EMBL | CBI24942.1 | 0 | 7 | 807 | 65 | 867 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_196873.1 | 0 | 26 | 807 | 22 | 805 | alpha-N-acetylglucosaminidase family / NAGLU family [Arabidopsis thaliana] |
| RefSeq | XP_002273084.1 | 0 | 9 | 807 | 2 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 23 | 808 | 20 | 806 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 54 | 797 | 175 | 867 | B Chain B, Reassembly And Co-Crystallization Of A Family 9 Processive Endoglucanase From Separately Expressed Gh9 And Cbm3c Modules |
| PDB | 2vcb_A | 0 | 54 | 797 | 175 | 867 | B Chain B, Reassembly And Co-Crystallization Of A Family 9 Processive Endoglucanase From Separately Expressed Gh9 And Cbm3c Modules |
| PDB | 2vca_A | 0 | 54 | 797 | 175 | 867 | B Chain B, Reassembly And Co-Crystallization Of A Family 9 Processive Endoglucanase From Separately Expressed Gh9 And Cbm3c Modules |
| PDB | 2vc9_A | 0 | 54 | 797 | 175 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 54 | 797 | 198 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
