| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_002619m |
| Family | AA3 |
| Protein Properties | Length: 714 Molecular Weight: 78802.6 Isoelectric Point: 7.5094 |
| Chromosome | Chromosome/Scaffold: 06635 Start: 125575 End: 130766 |
| Description | Long-chain fatty alcohol dehydrogenase family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 191 | 707 | 0 |
| PSLVIQCDAVVVGSGSGGGVVAGVLAKAGYKVLVIEKGSYFARSNLSLLEGPTMDEMYLGGGLMATDDMGIVILAGSTVGGGSAINWSASIRTPQHVINE WSDRYDLEIFDSTLYKEALDVVCQKMGVQSEIHQEGFNNSILRKGCQELGYPVNNIPRNSSPDHYCGWCCLGCKDGRKKSTCETWLLDLVNSGNGAILPR CEAIKVLHKEKRGRNSRRTATGVAFEFEYEGAKDLCVIESKVTIVASGAISTPPLLKRSGLKNPNIGKNLHLHPVVMAWGYFPDAPVSSKAWPEEQKKSY EGGIMTAMSTVVAKFDKSGYGAVIQTPSLHPGMFSSLMPWVSGMDIKTKMCRFSRTAHIFALARDKGKGTVNSPSSITYQMEDSDEENLQKGLEKMLRIL AAAGAEEIGTHHSTGRSINVKKVSYNEFEKFVKEESERPLRDLSTQLCSAHQMGSCRMGVNPKDSVVNQMGETWEVEGLFVADSSVFPTALGVNPMVTIQ AVAYCTAQSVLEALRRK | |||
| Full Sequence |
|---|
| Protein Sequence Length: 714 Download |
| MHILQVGGLI SERLKHPKKW LIELALWMLS TWIGTFILCG LSSISLHFPY FQTFSQLPLH 60 KREQILHSWS LSFFYPLRML FKAIKLLTLI VFFSQVDEKN ENLTWKAIGY PGPDPEFKAL 120 KLSQYGKLED KEDDEEEEDD DEEEKLFAPL HRGLVNMNLP RDRLANSLQL AGFPVLTHRP 180 KSNAACSPSN PSLVIQCDAV VVGSGSGGGV VAGVLAKAGY KVLVIEKGSY FARSNLSLLE 240 GPTMDEMYLG GGLMATDDMG IVILAGSTVG GGSAINWSAS IRTPQHVINE WSDRYDLEIF 300 DSTLYKEALD VVCQKMGVQS EIHQEGFNNS ILRKGCQELG YPVNNIPRNS SPDHYCGWCC 360 LGCKDGRKKS TCETWLLDLV NSGNGAILPR CEAIKVLHKE KRGRNSRRTA TGVAFEFEYE 420 GAKDLCVIES KVTIVASGAI STPPLLKRSG LKNPNIGKNL HLHPVVMAWG YFPDAPVSSK 480 AWPEEQKKSY EGGIMTAMST VVAKFDKSGY GAVIQTPSLH PGMFSSLMPW VSGMDIKTKM 540 CRFSRTAHIF ALARDKGKGT VNSPSSITYQ MEDSDEENLQ KGLEKMLRIL AAAGAEEIGT 600 HHSTGRSINV KKVSYNEFEK FVKEESERPL RDLSTQLCSA HQMGSCRMGV NPKDSVVNQM 660 GETWEVEGLF VADSSVFPTA LGVNPMVTIQ AVAYCTAQSV LEALRRKKKL LVN* 720 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| PRK02106 | PRK02106 | 1.0e-5 | 617 | 679 | 64 | + choline dehydrogenase; Validated | ||
| TIGR01810 | betA | 2.0e-7 | 366 | 710 | 377 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| pfam05199 | GMC_oxred_C | 1.0e-23 | 567 | 694 | 128 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
| COG2303 | BetA | 3.0e-43 | 215 | 703 | 550 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| pfam00732 | GMC_oxred_N | 6.0e-75 | 244 | 465 | 225 | + GMC oxidoreductase. This family of proteins bind FAD as a cofactor. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI29206.1 | 0 | 6 | 713 | 82 | 653 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_193673.2 | 0 | 5 | 708 | 43 | 726 | alcohol oxidase-related [Arabidopsis thaliana] |
| RefSeq | XP_002269629.1 | 0 | 6 | 709 | 82 | 788 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002328753.1 | 0 | 5 | 708 | 49 | 745 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002519938.1 | 0 | 1 | 708 | 1 | 709 | electron carrier, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 1ju2_B | 0.000005 | 198 | 464 | 28 | 299 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 1ju2_A | 0.000005 | 198 | 464 | 28 | 299 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdp_B | 0.000005 | 198 | 464 | 28 | 299 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdp_A | 0.000005 | 198 | 464 | 28 | 299 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdn_B | 0.000005 | 198 | 464 | 28 | 299 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
