| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_003710m |
| Family | GH89 |
| Protein Properties | Length: 622 Molecular Weight: 71280 Isoelectric Point: 5.5175 |
| Chromosome | Chromosome/Scaffold: 06659 Start: 268488 End: 278299 |
| Description | alpha-N-acetylglucosaminidase family / NAGLU family |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| GH89 | 1 | 617 | 0 |
| MALQGINLPLAFTGQEAIWQKVFMNLNVSSEDLNDFFGGPAFLAWARMGNLHAWGGPLSQNWLDQQLSLQKQILSRMLELGMTPVLPSFSGNVPAALKKI FPSANITRLGDWNTVNKNPRWCCTYLLDPSDPLFVEIGEAFIRQQIKEYGDVTDIYNCDTFNENIPPTNDSDYISSLGAAVYKAMSKGDEDAVWLMQGWL FYSDSSFWKPPQMKALLHSVPFGKMIVLDLFADVKPIWRTSSQFYGTPYVWCMLHNFGGNIEMYGILDAISSGPIDAHISENSTMVGVGMCMEGIEHNPV VYELMSEMAFRSEKVRVLEWLRNYSRRRYGKAVNQVEAAWEILYRTIYNCTDGIADHNRDFIVKFPDWDPSLNSGSDTSKEDTKHIFLSLPRTRRFLFQQ SSSKLPQAHLWYSTQEVVNALQLFLDAGNDLNRSLTYRYDLVDLTRQVLSKLANQVYIDAIIAFQRKDADALNLHSQKFLQLINDIDVLLASDDNFLLGT WLESAKELGVNPVEMKQYEWNARTQVTMWYDTTKTNQSQLHDYANKFWSGLLKDYYLPRASTYFDHLAKSLKENENFNIVGWREEWIAFSNKWQVSTELY PVKARGDALAISKALYK | |||
| Full Sequence |
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| Protein Sequence Length: 622 Download |
| MALQGINLPL AFTGQEAIWQ KVFMNLNVSS EDLNDFFGGP AFLAWARMGN LHAWGGPLSQ 60 NWLDQQLSLQ KQILSRMLEL GMTPVLPSFS GNVPAALKKI FPSANITRLG DWNTVNKNPR 120 WCCTYLLDPS DPLFVEIGEA FIRQQIKEYG DVTDIYNCDT FNENIPPTND SDYISSLGAA 180 VYKAMSKGDE DAVWLMQGWL FYSDSSFWKP PQMKALLHSV PFGKMIVLDL FADVKPIWRT 240 SSQFYGTPYV WCMLHNFGGN IEMYGILDAI SSGPIDAHIS ENSTMVGVGM CMEGIEHNPV 300 VYELMSEMAF RSEKVRVLEW LRNYSRRRYG KAVNQVEAAW EILYRTIYNC TDGIADHNRD 360 FIVKFPDWDP SLNSGSDTSK EDTKHIFLSL PRTRRFLFQQ SSSKLPQAHL WYSTQEVVNA 420 LQLFLDAGND LNRSLTYRYD LVDLTRQVLS KLANQVYIDA IIAFQRKDAD ALNLHSQKFL 480 QLINDIDVLL ASDDNFLLGT WLESAKELGV NPVEMKQYEW NARTQVTMWY DTTKTNQSQL 540 HDYANKFWSG LLKDYYLPRA STYFDHLAKS LKENENFNIV GWREEWIAFS NKWQVSTELY 600 PVKARGDALA ISKALYKRYF G* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam12972 | NAGLU_C | 1.0e-108 | 319 | 619 | 301 | + Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold. | ||
| pfam05089 | NAGLU | 2.0e-168 | 1 | 314 | 314 | + Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain. Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterized by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This central domain has a tim barrel fold. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI24942.1 | 0 | 1 | 620 | 247 | 867 | unnamed protein product [Vitis vinifera] |
| GenBank | EEC75285.1 | 0 | 1 | 620 | 196 | 811 | hypothetical protein OsI_11626 [Oryza sativa Indica Group] |
| GenBank | EEE59081.1 | 0 | 1 | 620 | 196 | 811 | hypothetical protein OsJ_10898 [Oryza sativa Japonica Group] |
| RefSeq | XP_002273084.1 | 0 | 1 | 620 | 182 | 802 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002314048.1 | 0 | 1 | 621 | 186 | 806 | predicted protein [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2vcc_A | 0 | 2 | 610 | 298 | 867 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vcb_A | 0 | 2 | 610 | 298 | 867 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vca_A | 0 | 2 | 610 | 298 | 867 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| PDB | 2vc9_A | 0 | 2 | 610 | 298 | 867 | A Chain A, Family 89 Glycoside Hydrolase From Clostridium Perfringens In Complex With 2-Acetamido-1,2-Dideoxynojirmycin |
| PDB | 4a4a_A | 0 | 2 | 610 | 321 | 890 | A Chain A, Cpgh89 (E483q, E601q), From Clostridium Perfringens, In Complex With Its Substrate Glcnac-Alpha-1,4-Galactose |
| Hydropathy |
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| EST Download unfiltered results here | ||||
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| Hit | Length | Start | End | EValue |
| HO783455 | 323 | 120 | 442 | 0 |
| HO783455 | 148 | 451 | 598 | 0 |
| GT627657 | 271 | 22 | 292 | 0 |
| GT622356 | 273 | 95 | 367 | 0 |
| HO783455 | 32 | 442 | 473 | 3.2 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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