| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_004445m |
| Family | AA3 |
| Protein Properties | Length: 577 Molecular Weight: 62306.9 Isoelectric Point: 7.8605 |
| Chromosome | Chromosome/Scaffold: 07035 Start: 322839 End: 326212 |
| Description | Glucose-methanol-choline (GMC) oxidoreductase family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| AA3 | 43 | 569 | 0 |
| ISYYDYIIVGGGTAGCPLAATLSQNTTVLLLERGGSPYGNPNITNLSNFGAALSDLSPTSPSQRFISEDGVINARARVLGGGSCINAGFYTRASNDYVRN VGWDGRLVNESYQWVEQQVAFKPEVGQWQSAIRDGLVEVGVVPNNGFTYDHIYGTKVGGTIFDRDGNRHTAADLLEHANPSGLTVLLHATVHKIFFRIKG KPRPVAHGVAFRDASGAKHRAYLKKGSKNEIIISAGALGTPQLLMLSGVGPKAQLQAHNIPVVLDQPMVGQLMSDNPMNAVYIPSPIPVEVSLIEVVGIT QFGSYIEAASGANFAGVSRRDFGLFSPKIGQLSTVPPKQRTPEAIAKAIELMNNLDEAAFRGGFIIEKIMGPISTGHLELRTRNPSDNPSVTFNYFKEPQ DLQKCVQGISVIENVIDSKPFSKFKYDDLSVPQLLNMTASSPVNLLPRHQNTSTSLEQFCKDTVMTIWHYHGGCQVGSVVDSNYKVLGVDALRVIDGSTF NNSPGTNPQATCMMLGRYMGAKILRER | |||
| Full Sequence |
|---|
| Protein Sequence Length: 577 Download |
| MDLVGLWRFS AAASFIVLVL FHGFCASAKD YSFMHDATSA PEISYYDYII VGGGTAGCPL 60 AATLSQNTTV LLLERGGSPY GNPNITNLSN FGAALSDLSP TSPSQRFISE DGVINARARV 120 LGGGSCINAG FYTRASNDYV RNVGWDGRLV NESYQWVEQQ VAFKPEVGQW QSAIRDGLVE 180 VGVVPNNGFT YDHIYGTKVG GTIFDRDGNR HTAADLLEHA NPSGLTVLLH ATVHKIFFRI 240 KGKPRPVAHG VAFRDASGAK HRAYLKKGSK NEIIISAGAL GTPQLLMLSG VGPKAQLQAH 300 NIPVVLDQPM VGQLMSDNPM NAVYIPSPIP VEVSLIEVVG ITQFGSYIEA ASGANFAGVS 360 RRDFGLFSPK IGQLSTVPPK QRTPEAIAKA IELMNNLDEA AFRGGFIIEK IMGPISTGHL 420 ELRTRNPSDN PSVTFNYFKE PQDLQKCVQG ISVIENVIDS KPFSKFKYDD LSVPQLLNMT 480 ASSPVNLLPR HQNTSTSLEQ FCKDTVMTIW HYHGGCQVGS VVDSNYKVLG VDALRVIDGS 540 TFNNSPGTNP QATCMMLGRY MGAKILRERL ASEGSK* 600 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam05199 | GMC_oxred_C | 6.0e-25 | 414 | 558 | 150 | + GMC oxidoreductase. This domain found associated with pfam00732. | ||
| TIGR03970 | Rv0697 | 3.0e-30 | 47 | 558 | 563 | + dehydrogenase, Rv0697 family. This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function. | ||
| TIGR01810 | betA | 1.0e-34 | 47 | 558 | 567 | + choline dehydrogenase. Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli , Staphylococcus xylosus , and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. | ||
| COG2303 | BetA | 4.0e-47 | 46 | 572 | 570 | + Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism] | ||
| PLN02785 | PLN02785 | 0 | 27 | 570 | 556 | + Protein HOTHEAD | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors |
| GO:0050660 | flavin adenine dinucleotide binding |
| GO:0055114 | oxidation-reduction process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI34759.1 | 0 | 22 | 576 | 21 | 578 | unnamed protein product [Vitis vinifera] |
| RefSeq | NP_001053612.1 | 0 | 1 | 574 | 5 | 585 | Os04g0573100 [Oryza sativa (japonica cultivar-group)] |
| RefSeq | XP_002282510.1 | 0 | 34 | 576 | 1 | 544 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002298074.1 | 0 | 4 | 573 | 3 | 573 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002509694.1 | 0 | 1 | 576 | 3 | 548 | glucose-methanol-choline (gmc) oxidoreductase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 1ju2_B | 0 | 32 | 573 | 13 | 521 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 1ju2_A | 0 | 32 | 573 | 13 | 521 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdp_B | 0 | 32 | 573 | 13 | 521 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdp_A | 0 | 32 | 573 | 13 | 521 | A Chain A, Crystal Structure Of The Hydroxynitrile Lyase From Almond |
| PDB | 3gdn_B | 0 | 32 | 573 | 13 | 521 | A Chain A, Almond Hydroxynitrile Lyase In Complex With Benzaldehyde |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| cutin biosynthesis | RXN-2121 | EC-1.1.1 | 18-hydroxyoleate dehydrogenase |
| cutin biosynthesis | RXN-9802 | EC-1.1.1 | 16-hydroxypalmitate dehydrogenase |
| suberin biosynthesis | RXN-2121 | EC-1.1.1 | 18-hydroxyoleate dehydrogenase |
