| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_005011m |
| Family | GH79 |
| Protein Properties | Length: 545 Molecular Weight: 60105.1 Isoelectric Point: 7.3471 |
| Chromosome | Chromosome/Scaffold: 00232 Start: 18956 End: 21613 |
| Description | glucuronidase 3 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
 | |||
| Family | Start | End | Evalue |
| GH79 | 51 | 537 | 0 |
| DEDFICATLDWWPPEKCDYGTCSWDYASLINLDLSSNILLNAIKAFSPLKIRLGGTLQDKVIYDTDDNKEPCKQFVKNTTEMFGFTQGCLPMYRWDELNE FFKKSGAKIIFGLNALAGRSIQSDGSAAGAWNYTNAESFISYTIRKNYSIHGWELGNELSGSGVGTRIAADQYAADTISLYKIVQKIYSGAESKPLVIAP GGFFDANWFKEFIDKTGNSVDVITHHIYNLGPGVDEHLVEKILNPSYLDGEADTFSGLQNTLKSSATSATAWVGEAGGAYNSGRNLVSNAFVYSFWYLDQ LGMASAYDTKTYCRQSLIGGNYGLLNTTTFLPNPDYYSALLWHRLMGRKVLSTKFSGAKTIRAYAHCAKESKGITLLLINLDNSTTVEVKVSFNSTWTLH HQKKHHRSYKSHRTRTIKLPQGSESTTREEYHLTAKDGNLHSQIMLLNGNILSVSSSGEIAAFEPVNVNLTKPIFVAPFSVVFAHLP | |||
| Full Sequence |
|---|
| Protein Sequence Length: 545 Download |
| MGSQIWMRRL LILLCIFSCS FAYVSSQSVA GDGSVEGTVF IDGKSSIGKI DEDFICATLD 60 WWPPEKCDYG TCSWDYASLI NLDLSSNILL NAIKAFSPLK IRLGGTLQDK VIYDTDDNKE 120 PCKQFVKNTT EMFGFTQGCL PMYRWDELNE FFKKSGAKII FGLNALAGRS IQSDGSAAGA 180 WNYTNAESFI SYTIRKNYSI HGWELGNELS GSGVGTRIAA DQYAADTISL YKIVQKIYSG 240 AESKPLVIAP GGFFDANWFK EFIDKTGNSV DVITHHIYNL GPGVDEHLVE KILNPSYLDG 300 EADTFSGLQN TLKSSATSAT AWVGEAGGAY NSGRNLVSNA FVYSFWYLDQ LGMASAYDTK 360 TYCRQSLIGG NYGLLNTTTF LPNPDYYSAL LWHRLMGRKV LSTKFSGAKT IRAYAHCAKE 420 SKGITLLLIN LDNSTTVEVK VSFNSTWTLH HQKKHHRSYK SHRTRTIKLP QGSESTTREE 480 YHLTAKDGNL HSQIMLLNGN ILSVSSSGEI AAFEPVNVNL TKPIFVAPFS VVFAHLPYVV 540 PACS* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
 | ||||||||
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 0 | 35 | 352 | 319 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAN81917.1 | 0 | 1 | 543 | 1 | 554 | hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002263173.1 | 0 | 1 | 543 | 5 | 558 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002324603.1 | 0 | 37 | 544 | 1 | 506 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002331013.1 | 0 | 10 | 544 | 3 | 547 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002533671.1 | 0 | 1 | 543 | 1 | 550 | heparanase, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000000001 | 146 | 442 | 122 | 409 | A Chain A, Pectin Methylesterase From Yersinia Enterocolitica |
| PDB | 3vnz_A | 0.0000000001 | 146 | 442 | 122 | 409 | A Chain A, Pectin Methylesterase From Yersinia Enterocolitica |
| PDB | 3vny_A | 0.0000000001 | 146 | 442 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
