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Basic Information | |
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Species | Manihot esculenta |
Cazyme ID | cassava4.1_005072m |
Family | GH79 |
Protein Properties | Length: 543 Molecular Weight: 60379.6 Isoelectric Point: 7.239 |
Chromosome | Chromosome/Scaffold: 08359 Start: 1631735 End: 1637842 |
Description | glucuronidase 2 |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GH79 | 43 | 536 | 0 |
DDNFICATLDWWPPDKCDYNQCPWHNSSVLNLDLSHPLLGKAIQAFRYLRIRIGGSLQDQVLYEVGNLTSPCHPFRKIKGGLFGFSKGCLPMNRWDELND FFSKTGAIVTFSLNALHGRHWIRRSVWGGAWDSSNAYDFMNYTVSKGHKIDSWEFGNELSGSGVGASVSAELYGKDVINLKDIIKDLYKNSDVKPLLVAP GGFYNQQWFAKFLQVSGSGIVNILTHHIYNLGAGVDPNLTNKILDPQYLSRISETFSGLVQTIQDNGPWASAWVGESGGAYNSGGRHVSNTFINSFWYLD QLGMAAKYHTKVYCRQTLIGGNYGLLNTTTFVPNPDYYSALFWHRLMGKGVLAVGSDASPYLRAYAHCSKGRAGITLLLINLSNQTDFIISVRNSLTMRL HVEKKVQRESLLMRSLKRSVSWVGNEASEGATREEYHLTPKDGYLQSETMVLNGIPLELTENGDIPRLDPVHNNVNSPIYINPLSISFIVFPNF |
Full Sequence |
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Protein Sequence Length: 543 Download |
MNQPMGFGLS LLFFLASMPI IFAQDVKHAT IVVDGTLTIA ETDDNFICAT LDWWPPDKCD 60 YNQCPWHNSS VLNLDLSHPL LGKAIQAFRY LRIRIGGSLQ DQVLYEVGNL TSPCHPFRKI 120 KGGLFGFSKG CLPMNRWDEL NDFFSKTGAI VTFSLNALHG RHWIRRSVWG GAWDSSNAYD 180 FMNYTVSKGH KIDSWEFGNE LSGSGVGASV SAELYGKDVI NLKDIIKDLY KNSDVKPLLV 240 APGGFYNQQW FAKFLQVSGS GIVNILTHHI YNLGAGVDPN LTNKILDPQY LSRISETFSG 300 LVQTIQDNGP WASAWVGESG GAYNSGGRHV SNTFINSFWY LDQLGMAAKY HTKVYCRQTL 360 IGGNYGLLNT TTFVPNPDYY SALFWHRLMG KGVLAVGSDA SPYLRAYAHC SKGRAGITLL 420 LINLSNQTDF IISVRNSLTM RLHVEKKVQR ESLLMRSLKR SVSWVGNEAS EGATREEYHL 480 TPKDGYLQSE TMVLNGIPLE LTENGDIPRL DPVHNNVNSP IYINPLSISF IVFPNFDAPS 540 CE* 600 |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03662 | Glyco_hydro_79n | 0 | 29 | 345 | 317 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
GO:0016798 | hydrolase activity, acting on glycosyl bonds |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
EMBL | CBI15157.1 | 0 | 5 | 541 | 1 | 512 | unnamed protein product [Vitis vinifera] |
RefSeq | NP_196400.2 | 0 | 5 | 541 | 1 | 542 | AtGUS2 (Arabidopsis thaliana glucuronidase 2); beta-glucuronidase |
RefSeq | XP_002284470.1 | 0 | 5 | 541 | 1 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002321464.1 | 0 | 5 | 541 | 1 | 540 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002514696.1 | 0 | 19 | 541 | 15 | 538 | Heparanase-2, putative [Ricinus communis] |
Annotations - PDB Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
PDB | 3vo0_A | 0.000001 | 138 | 433 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
PDB | 3vnz_A | 0.000001 | 138 | 433 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
PDB | 3vny_A | 0.000001 | 138 | 433 | 122 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |