Basic Information | |
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Species | Manihot esculenta |
Cazyme ID | cassava4.1_006493m |
Family | GT47 |
Protein Properties | Length: 486 Molecular Weight: 54739.9 Isoelectric Point: 9.3481 |
Chromosome | Chromosome/Scaffold: 07519 Start: 204580 End: 207159 |
Description | Exostosin family protein |
View CDS |
Signature Domain Download full data set without filtering | |||
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Family | Start | End | Evalue |
GT47 | 64 | 410 | 0 |
NTLKVYLADLPRSLNYGLLDQYWSSSVPDSRISSDPDHPLIQKRKSSKFPPYPENPLIKQYSAEYWITGDLMTPENLRTQSFAKRVLDVNQADVVFVPFF ATLSAEMELGRGKGTFRKKDGNEDYKRQKDVIEFVKSSEAWKRSGGRDHVFVLTDPVAMWHVRSEIAPAILLVVDFGGWYRLDSKSSNGNSSDRIQHTQV SLLKDVIVPYTHLLPRLDLSENKKRHTLLYFKGAKHRHRGGIVREKLWDLLFNEPGVIMEEGFPNASGREQSIRGMRTSEFCLHPSGDTPTSCRLFDAIQ SLCIPVIVSDNIELPFEGMVDYSEFSVFVAVDDALKPSWLVDHLKRI |
Full Sequence |
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Protein Sequence Length: 486 Download |
MPPPMTAAVT VSTATRKTTP SCSIPSLFLI FILVSVLSLS LFLLFSDTSP SFQNPQSTIQ 60 ASSNTLKVYL ADLPRSLNYG LLDQYWSSSV PDSRISSDPD HPLIQKRKSS KFPPYPENPL 120 IKQYSAEYWI TGDLMTPENL RTQSFAKRVL DVNQADVVFV PFFATLSAEM ELGRGKGTFR 180 KKDGNEDYKR QKDVIEFVKS SEAWKRSGGR DHVFVLTDPV AMWHVRSEIA PAILLVVDFG 240 GWYRLDSKSS NGNSSDRIQH TQVSLLKDVI VPYTHLLPRL DLSENKKRHT LLYFKGAKHR 300 HRGGIVREKL WDLLFNEPGV IMEEGFPNAS GREQSIRGMR TSEFCLHPSG DTPTSCRLFD 360 AIQSLCIPVI VSDNIELPFE GMVDYSEFSV FVAVDDALKP SWLVDHLKRI SEKQRNEFRQ 420 KMAKVQPIFV YDNGHPGSVG PVPPDGAVNH IWKKVHQKLP MIKEAIVREK RKPAGVSIPL 480 RCHCT* |
Functional Domains Download unfiltered results here | ||||||||
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Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
pfam03016 | Exostosin | 8.0e-59 | 66 | 410 | 357 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. |
Gene Ontology | |
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GO Term | Description |
GO:0016020 | membrane |
Annotations - NR Download unfiltered results here | |||||||
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Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
RefSeq | NP_564443.1 | 0 | 44 | 484 | 40 | 476 | exostosin family protein [Arabidopsis thaliana] |
RefSeq | XP_002270238.1 | 0 | 8 | 485 | 2 | 440 | PREDICTED: hypothetical protein [Vitis vinifera] |
RefSeq | XP_002325567.1 | 0 | 22 | 485 | 13 | 476 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002327326.1 | 0 | 37 | 485 | 1 | 449 | predicted protein [Populus trichocarpa] |
RefSeq | XP_002533317.1 | 0 | 51 | 485 | 40 | 478 | catalytic, putative [Ricinus communis] |