| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_007711m |
| Family | GT65 |
| Protein Properties | Length: 445 Molecular Weight: 50686.6 Isoelectric Point: 9.5775 |
| Chromosome | Chromosome/Scaffold: 02165 Start: 485050 End: 487179 |
| Description | O-fucosyltransferase family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT65 | 81 | 392 | 0 |
| GLNNQKIAFARASLTARMLNRTLLMPSLSASLFYKELDRLQPISFDKVFQFERFNSLCNGFVQLGQYSFLRNQTGVSELQKGSGRKWTIERDLDQLRQFS KDPYDKYEVIRIVGKNPFLWHDHWPVKDYARVFECLVLVEEIEREASKVVAKIREVGREISGQTKSGQNSIDSDGSSLQAVPYVAVHMRIEIDWVIHCRK LEQRSKMSQICSSKEEIMERVGNIAGLKAPMVVYLAVADSLLEDPSILTGWRDGLLPFEKKKLRVDGIYKKHPYLIQSAIDYEVCLRADVFVGNSFSTFS SLIALERTQKMI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 445 Download |
| MDLPSKHPRF FGRHLNSVAC KCVALVVILL FLRVVLLPSF SGFDSINHNN AQLTRSRSLS 60 LESKYGIRRD KFLEVPQIVW GLNNQKIAFA RASLTARMLN RTLLMPSLSA SLFYKELDRL 120 QPISFDKVFQ FERFNSLCNG FVQLGQYSFL RNQTGVSELQ KGSGRKWTIE RDLDQLRQFS 180 KDPYDKYEVI RIVGKNPFLW HDHWPVKDYA RVFECLVLVE EIEREASKVV AKIREVGREI 240 SGQTKSGQNS IDSDGSSLQA VPYVAVHMRI EIDWVIHCRK LEQRSKMSQI CSSKEEIMER 300 VGNIAGLKAP MVVYLAVADS LLEDPSILTG WRDGLLPFEK KKLRVDGIYK KHPYLIQSAI 360 DYEVCLRADV FVGNSFSTFS SLIALERTQK MIRMGITSSC GTHVRWPSYA YNILGESNGP 420 QRWMTNMSDS SLKAISYGTN IISC* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd11296 | O-FucT_like | 0.0004 | 72 | 124 | 56 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11302 | O-FucT-1 | 1.0e-7 | 262 | 387 | 146 | + GDP-fucose protein O-fucosyltransferase 1. The protein O-fucosyltransferase 1 (Ofut1 or O-FucT-1) adds O-fucose to EGF (epidermal growth factor-like) repeats. The O-fucsosylation of the Notch receptor signaling protein is dependent on this enzyme, which requires GDP-fucose as a substrate. O-fucose residues added to the target of O-FucT-1 may be further elongated by other glycosyltransferases. On top of O-fucosylation, O-FucT-1 may have other functions such as the regulation of the Notch receptor exit from the ER. Six highly conserved cysteines are present in O-FucT-1, which is a soluble ER protein, as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The membrane-bound pre-protein is released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. O-FucT-1 is similar to family 1 glycosyltransferases (GT1). | ||
| cd11299 | O-FucT_plant | 8.0e-16 | 81 | 388 | 335 | + GDP-fucose protein O-fucosyltransferase, plant specific subfamily. Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| cd11296 | O-FucT_like | 7.0e-23 | 202 | 388 | 191 | + GDP-fucose protein O-fucosyltransferase and related proteins. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. | ||
| pfam10250 | O-FucT | 1.0e-42 | 81 | 388 | 339 | + GDP-fucose protein O-fucosyltransferase. This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteristic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese. | ||
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| RefSeq | NP_187183.3 | 0 | 3 | 444 | 5 | 442 | unknown protein [Arabidopsis thaliana] |
| RefSeq | XP_002273827.1 | 0 | 18 | 444 | 1 | 427 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321799.1 | 0 | 98 | 444 | 1 | 347 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002332132.1 | 0 | 98 | 444 | 1 | 347 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002531235.1 | 0 | 1 | 444 | 1 | 446 | conserved hypothetical protein [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3zy6_A | 0.00004 | 260 | 387 | 210 | 344 | A Chain A, Family Gh5 Endo-Beta-Mannanase From Lycopersicon Esculentum (Tomato) |
| PDB | 3zy5_A | 0.00004 | 260 | 387 | 210 | 344 | A Chain A, Family Gh5 Endo-Beta-Mannanase From Lycopersicon Esculentum (Tomato) |
| PDB | 3zy4_A | 0.00004 | 260 | 387 | 210 | 344 | A Chain A, Family Gh5 Endo-Beta-Mannanase From Lycopersicon Esculentum (Tomato) |
| PDB | 3zy3_B | 0.00004 | 260 | 387 | 210 | 344 | A Chain A, Family Gh5 Endo-Beta-Mannanase From Lycopersicon Esculentum (Tomato) |
| PDB | 3zy3_A | 0.00004 | 260 | 387 | 210 | 344 | A Chain A, Family Gh5 Endo-Beta-Mannanase From Lycopersicon Esculentum (Tomato) |
