| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_008768m |
| Family | GH79 |
| Protein Properties | Length: 410 Molecular Weight: 45568.4 Isoelectric Point: 7.409 |
| Chromosome | Chromosome/Scaffold: 08359 Start: 1631735 End: 1637842 |
| Description | glucuronidase 2 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 1 | 403 | 0 |
| MNRWDELNDFFSKTGAIVTFSLNALHGRHWIRRSVWGGAWDSSNAYDFMNYTVSKGHKIDSWEFGNELSGSGVGASVSAELYGKDVINLKDIIKDLYKNS DVKPLLVAPGGFYNQQWFAKFLQVSGSGIVNILTHHIYNLGAGVDPNLTNKILDPQYLSRISETFSGLVQTIQDNGPWASAWVGESGGAYNSGGRHVSNT FINSFWYLDQLGMAAKYHTKVYCRQTLIGGNYGLLNTTTFVPNPDYYSALFWHRLMGKGVLAVGSDASPYLRAYAHCSKGRAGITLLLINLSNQTDFIIS VRNSLTMRLHVEKKVQRESLLMRSLKRSVSWVGNEASEGATREEYHLTPKDGYLQSETMVLNGIPLELTENGDIPRLDPVHNNVNSPIYINPLSISFIVF PNF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 410 Download |
| MNRWDELNDF FSKTGAIVTF SLNALHGRHW IRRSVWGGAW DSSNAYDFMN YTVSKGHKID 60 SWEFGNELSG SGVGASVSAE LYGKDVINLK DIIKDLYKNS DVKPLLVAPG GFYNQQWFAK 120 FLQVSGSGIV NILTHHIYNL GAGVDPNLTN KILDPQYLSR ISETFSGLVQ TIQDNGPWAS 180 AWVGESGGAY NSGGRHVSNT FINSFWYLDQ LGMAAKYHTK VYCRQTLIGG NYGLLNTTTF 240 VPNPDYYSAL FWHRLMGKGV LAVGSDASPY LRAYAHCSKG RAGITLLLIN LSNQTDFIIS 300 VRNSLTMRLH VEKKVQRESL LMRSLKRSVS WVGNEASEGA TREEYHLTPK DGYLQSETMV 360 LNGIPLELTE NGDIPRLDPV HNNVNSPIYI NPLSISFIVF PNFDAPSCE* 420 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 2.0e-116 | 1 | 212 | 212 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CAB62595.1 | 0 | 1 | 408 | 113 | 520 | putative protein [Arabidopsis thaliana] |
| EMBL | CBI15157.1 | 0 | 1 | 408 | 130 | 512 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002284470.1 | 0 | 1 | 408 | 130 | 538 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002321464.1 | 0 | 1 | 408 | 130 | 540 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002514696.1 | 0 | 1 | 408 | 130 | 538 | Heparanase-2, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000008 | 7 | 300 | 124 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vnz_A | 0.0000008 | 7 | 300 | 124 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| PDB | 3vny_A | 0.0000008 | 7 | 300 | 124 | 409 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
| Hydropathy |
|---|
 |
| EST Download unfiltered results here | ||||
|---|---|---|---|---|
| Hit | Length | Start | End | EValue |
| HO797031 | 369 | 43 | 408 | 0 |
| EG664145 | 269 | 97 | 364 | 0 |
| JG001113 | 247 | 55 | 301 | 0 |
| HO781548 | 330 | 82 | 408 | 0 |
| GH270908 | 270 | 31 | 300 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
|---|
 |
