| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_012979m |
| Family | GH18 |
| Protein Properties | Length: 295 Molecular Weight: 31139.2 Isoelectric Point: 5.7705 |
| Chromosome | Chromosome/Scaffold: 06814 Start: 537473 End: 538406 |
| Description | chitinase A |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH18 | 25 | 242 | 4.2e-33 |
| IAIYWGQNGNEGTLAETCATGKYDYVNIAFLSSFGNGQTPTINLAGHCDPNSNGCTSLSSDIKSCQSKGVKVILSIGGGAGGYSLASAADARQVATYLWN NFLGGKSSSRPLGPAVLDGIDFDIEGGTNLYWDDLARYLSAYSKKGKKVYLTAAPQCPFPDAWIGNALKTGLFDYVWVQFYNNPPCQYSGDATNLEDAWK QWTSDIPANKIFLGLPAS | |||
| Full Sequence |
|---|
| Protein Sequence Length: 295 Download |
| MALQKLFILT LVLLVLAACS DAGGIAIYWG QNGNEGTLAE TCATGKYDYV NIAFLSSFGN 60 GQTPTINLAG HCDPNSNGCT SLSSDIKSCQ SKGVKVILSI GGGAGGYSLA SAADARQVAT 120 YLWNNFLGGK SSSRPLGPAV LDGIDFDIEG GTNLYWDDLA RYLSAYSKKG KKVYLTAAPQ 180 CPFPDAWIGN ALKTGLFDYV WVQFYNNPPC QYSGDATNLE DAWKQWTSDI PANKIFLGLP 240 ASPAAAGSGF IPVPDLVSNV LPAIKGSGKY GGVMLWSKYY DDQSGYSSSI KSHV* 300 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| cd02871 | GH18_chitinase_D-like | 0.0003 | 46 | 207 | 181 | + GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (GH18) domain, a chitin-binding domain, and a fibronectin type III domain. The chitin-binding and fibronectin type III domains are located either N-terminal or C-terminal to the catalytic domain. This family includes exochitinase Chi36 from Bacillus cereus. | ||
| COG3469 | COG3469 | 7.0e-7 | 142 | 282 | 179 | + Chitinase [Carbohydrate transport and metabolism] | ||
| pfam00704 | Glyco_hydro_18 | 4.0e-24 | 23 | 235 | 243 | + Glycosyl hydrolases family 18. | ||
| cd02877 | GH18_hevamine_XipI_class_III | 3.0e-113 | 23 | 292 | 280 | + This conserved domain family includes xylanase inhibitor Xip-I, and the class III plant chitinases such as hevamine, concanavalin B, and PPL2, all of which have a glycosyl hydrolase family 18 (GH18) domain. Hevamine is a class III endochitinase that hydrolyzes the linear polysaccharide chains of chitin and peptidoglycan and is important for defense against pathogenic bacteria and fungi. PPL2 (Parkia platycephala lectin 2) is a class III chitinase from Parkia platycephala seeds that hydrolyzes beta(1-4) glycosidic bonds linking 2-acetoamido-2-deoxy-beta-D-glucopyranose units in chitin. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| GO:0005975 | carbohydrate metabolic process |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ABF82271.1 | 0 | 1 | 294 | 5 | 298 | class III chitinase [Panax ginseng] |
| RefSeq | XP_002301383.1 | 0 | 1 | 294 | 1 | 298 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002320164.1 | 0 | 1 | 294 | 3 | 300 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002511934.1 | 0 | 1 | 294 | 1 | 298 | hevamine-A precursor, putative [Ricinus communis] |
| RefSeq | XP_002533316.1 | 0 | 1 | 294 | 1 | 298 | hevamine-A precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 2hvm_A | 0 | 23 | 294 | 1 | 273 | A Chain A, Crystal Structure Of Apo Form (Zinc Removed) Of The Botulinum Neurotoxin Type C Light Chain |
| PDB | 1llo_A | 0 | 23 | 294 | 1 | 273 | A Chain A, Crystal Structure Of Apo Form (Zinc Removed) Of The Botulinum Neurotoxin Type C Light Chain |
| PDB | 1hvq_A | 0 | 23 | 294 | 1 | 273 | A Chain A, Crystal Structures Of Hevamine, A Plant Defence Protein With Chitinase And Lysozyme Activity, And Its Complex With An Inhibitor |
| PDB | 1kr0_A | 0 | 23 | 294 | 1 | 273 | A Chain A, Hevamine Mutant D125aY183F IN COMPLEX WITH TETRA-Nag |
| PDB | 1kr1_A | 0 | 23 | 294 | 1 | 273 | A Chain A, Hevamine Mutant D125aE127A IN COMPLEX WITH TETRA-Nag |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| chitin degradation II | 3.2.1.14-RXN | EC-3.2.1.14 | chitinase |
| chitin degradation II | RXN-12623 | EC-3.2.1.14 | chitinase |
| chitin degradation II | RXN-12624 | EC-3.2.1.14 | chitinase |
| chitin degradation III (carnivorous plants) | 3.2.1.14-RXN | EC-3.2.1.14 | chitinase |
