| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_013351m |
| Family | CE1 |
| Protein Properties | Length: 285 Molecular Weight: 31776.8 Isoelectric Point: 6.9073 |
| Chromosome | Chromosome/Scaffold: 06257 Start: 127033 End: 132432 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CE1 | 25 | 281 | 0 |
| SPTLGCSMTFHIYFPPSTSSSHKFPILYWLSGLTCTDENFIMKSGAQRAASANGVALIAPDTSPRGLNVEGESESWDFGVGAGFYLNATQEKWKNWRMYD YVVKELPKLLSNNFPQLDTSRASISGHSMGGHGALTIYLKNLDKYKSVSAFAPIANPINCPWGQKAFTNYLGGNKADWEEYDATSLVSKFKDVSATILID QGEDDKFLHDQLLPHKFEEACRSGNVPLLLRIQPGYDHSYYFVSTFIDDHISHHAQA | |||
| Full Sequence |
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| Protein Sequence Length: 285 Download |
| METKPSEISS SKMFGGYNKR YKHFSPTLGC SMTFHIYFPP STSSSHKFPI LYWLSGLTCT 60 DENFIMKSGA QRAASANGVA LIAPDTSPRG LNVEGESESW DFGVGAGFYL NATQEKWKNW 120 RMYDYVVKEL PKLLSNNFPQ LDTSRASISG HSMGGHGALT IYLKNLDKYK SVSAFAPIAN 180 PINCPWGQKA FTNYLGGNKA DWEEYDATSL VSKFKDVSAT ILIDQGEDDK FLHDQLLPHK 240 FEEACRSGNV PLLLRIQPGY DHSYYFVSTF IDDHISHHAQ ALNL* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| COG1506 | DAP2 | 8.0e-5 | 19 | 278 | 280 | + Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism] | ||
| pfam00756 | Esterase | 1.0e-54 | 25 | 275 | 263 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 8.0e-85 | 1 | 284 | 313 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 2.0e-134 | 8 | 282 | 276 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 0 | 1 | 284 | 284 | + S-formylglutathione hydrolase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004091 | carboxylesterase activity |
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
| GO:0018738 | S-formylglutathione hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACJ11734.1 | 0 | 1 | 284 | 1 | 284 | S-formylglutathione hydrolase [Gossypium hirsutum] |
| GenBank | ACJ84789.1 | 0 | 6 | 284 | 7 | 284 | unknown [Medicago truncatula] |
| GenBank | ACU19052.1 | 0 | 1 | 284 | 1 | 284 | unknown [Glycine max] |
| RefSeq | XP_002284489.1 | 0 | 1 | 284 | 1 | 284 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
| RefSeq | XP_002308013.1 | 0 | 1 | 270 | 1 | 270 | esterase d, s-formylglutathione hydrolase [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 7 | 283 | 5 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 7 | 283 | 5 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 8 | 283 | 7 | 279 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 8 | 283 | 7 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 8 | 283 | 7 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| formaldehyde oxidation II (glutathione-dependent) | S-FORMYLGLUTATHIONE-HYDROLASE-RXN | EC-3.1.2.12 | S-formylglutathione hydrolase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
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| Hit | Length | Start | End | EValue |
| DT549152 | 282 | 1 | 282 | 0 |
| EC982699 | 284 | 1 | 284 | 0 |
| ES807790 | 285 | 1 | 285 | 0 |
| ES841762 | 280 | 1 | 280 | 0 |
| DV157903 | 285 | 1 | 285 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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