| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_014031m |
| Family | CE1 |
| Protein Properties | Length: 267 Molecular Weight: 29647.2 Isoelectric Point: 7.1153 |
| Chromosome | Chromosome/Scaffold: 06257 Start: 127033 End: 132432 |
| Description | S-formylglutathione hydrolase |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
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| Family | Start | End | Evalue |
| CE1 | 25 | 263 | 2.8e-40 |
| SPTLGCSMTFHIYFPPSTSSSHKFPSGAQRAASANGVALIAPDTSPRGLNVEGESESWDFGVGAGFYLNATQEKWKNWRMYDYVVKELPKLLSNNFPQLD TSRASISGHSMGGHGALTIYLKNLDKYKSVSAFAPIANPINCPWGQKAFTNYLGGNKADWEEYDATSLVSKFKDVSATILIDQGEDDKFLHDQLLPHKFE EACRSGNVPLLLRIQPGYDHSYYFVSTFIDDHISHHAQA | |||
| Full Sequence |
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| Protein Sequence Length: 267 Download |
| METKPSEISS SKMFGGYNKR YKHFSPTLGC SMTFHIYFPP STSSSHKFPS GAQRAASANG 60 VALIAPDTSP RGLNVEGESE SWDFGVGAGF YLNATQEKWK NWRMYDYVVK ELPKLLSNNF 120 PQLDTSRASI SGHSMGGHGA LTIYLKNLDK YKSVSAFAPI ANPINCPWGQ KAFTNYLGGN 180 KADWEEYDAT SLVSKFKDVS ATILIDQGED DKFLHDQLLP HKFEEACRSG NVPLLLRIQP 240 GYDHSYYFVS TFIDDHISHH AQALNL* |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
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| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| COG1506 | DAP2 | 5.0e-7 | 16 | 260 | 265 | + Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism] | ||
| pfam00756 | Esterase | 3.0e-43 | 25 | 257 | 262 | + Putative esterase. This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family. | ||
| COG0627 | COG0627 | 7.0e-70 | 1 | 266 | 313 | + Predicted esterase [General function prediction only] | ||
| TIGR02821 | fghA_ester_D | 1.0e-117 | 8 | 264 | 275 | + S-formylglutathione hydrolase. This model describes a protein family from bacteria, yeast, and human, with a conserved critical role in formaldehyde detoxification as S-formylglutathione hydrolase (EC 3.1.2.12). Members in eukaryotes such as the human protein are better known as esterase D (EC 3.1.1.1), an enzyme with broad specificity, although S-formylglutathione hydrolase has now been demonstrated as well [Cellular processes, Detoxification]. | ||
| PLN02442 | PLN02442 | 0 | 1 | 266 | 284 | + S-formylglutathione hydrolase | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0004091 | carboxylesterase activity |
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
| GO:0018738 | S-formylglutathione hydrolase activity |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACJ11734.1 | 0 | 1 | 266 | 1 | 284 | S-formylglutathione hydrolase [Gossypium hirsutum] |
| GenBank | ACJ84789.1 | 0 | 6 | 266 | 7 | 284 | unknown [Medicago truncatula] |
| GenBank | ACU19052.1 | 0 | 1 | 266 | 1 | 284 | unknown [Glycine max] |
| RefSeq | XP_002284489.1 | 0 | 1 | 266 | 1 | 284 | PREDICTED: hypothetical protein isoform 1 [Vitis vinifera] |
| RefSeq | XP_002308013.1 | 0 | 1 | 252 | 1 | 270 | esterase d, s-formylglutathione hydrolase [Populus trichocarpa] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3fcx_B | 0 | 7 | 265 | 5 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3fcx_A | 0 | 7 | 265 | 5 | 281 | A Chain A, Crystal Structure Of Human Esterase D |
| PDB | 3s8y_A | 0 | 8 | 265 | 7 | 279 | A Chain A, Bromide Soaked Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_B | 0 | 8 | 265 | 7 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| PDB | 3i6y_A | 0 | 8 | 265 | 7 | 279 | A Chain A, Structure Of An Esterase From The Oil-Degrading Bacterium Oleispira Antarctica |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| formaldehyde oxidation II (glutathione-dependent) | S-FORMYLGLUTATHIONE-HYDROLASE-RXN | EC-3.1.2.12 | S-formylglutathione hydrolase |
| Hydropathy |
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| EST Download unfiltered results here | ||||
|---|---|---|---|---|
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| Hit | Length | Start | End | EValue |
| EC982699 | 284 | 1 | 266 | 0 |
| DT549152 | 282 | 1 | 264 | 0 |
| ES807790 | 285 | 1 | 267 | 0 |
| DV157903 | 285 | 1 | 267 | 0 |
| ES841762 | 280 | 1 | 262 | 0 |
| Sequence Alignments (This image is cropped. Click for full image.) |
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| Phylogeny |
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