| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_021602m |
| Family | GH79 |
| Protein Properties | Length: 523 Molecular Weight: 58400.8 Isoelectric Point: 8.8617 |
| Chromosome | Chromosome/Scaffold: 00109 Start: 55070 End: 57676 |
| Description | glucuronidase 1 |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GH79 | 43 | 519 | 0 |
| DTFICATLDWWPSSKCDYGQCPWGRAGILNLNLKNKILVNAIKAFGNLRIRVGGSLEDQVVYKVGNAIKKFPHFKKSDKGMFGFSKGTLTMKRWDELNQL FNQTGVKLTFGLNALIGKLKSNDSNLWLRDWNPRNAHDLMKYTISKGYKIDSYELGNELSASGVSARLDPNQYAKDIIVLKKLIDKLYPDPETRPGVLGP AGFYEEKWFNKFFQATGPNIVEGVTHHIYNLGPGVDSTLIYKVQDPYYLDQIAETYKDLSSNIKEFAPWAGAWVGEAGGAYNSGGKDVSHTFANGFWYLD QLGMTSSFNHKVFCRQALIGGNYGLLNTTSFIPNPDYYGALLWHRLMGKEVLGASHNTTPYLRAYSHCSKNKPGIALLLINMSNQTSFSVSVLNDDSPYS DNYKLMNYKYGGIDKREEYHLTPKDGNIQSDVVLLNGTPLKLTTSLEIPEMKPVIVDPSSPITVVPDSIVYVTIKDF | |||
| Full Sequence |
|---|
| Protein Sequence Length: 523 Download |
| MAEFKLLLLS SLLIFFLSRF NSVAAEDVQL TVKGLTSIAK TEDTFICATL DWWPSSKCDY 60 GQCPWGRAGI LNLNLKNKIL VNAIKAFGNL RIRVGGSLED QVVYKVGNAI KKFPHFKKSD 120 KGMFGFSKGT LTMKRWDELN QLFNQTGVKL TFGLNALIGK LKSNDSNLWL RDWNPRNAHD 180 LMKYTISKGY KIDSYELGNE LSASGVSARL DPNQYAKDII VLKKLIDKLY PDPETRPGVL 240 GPAGFYEEKW FNKFFQATGP NIVEGVTHHI YNLGPGVDST LIYKVQDPYY LDQIAETYKD 300 LSSNIKEFAP WAGAWVGEAG GAYNSGGKDV SHTFANGFWY LDQLGMTSSF NHKVFCRQAL 360 IGGNYGLLNT TSFIPNPDYY GALLWHRLMG KEVLGASHNT TPYLRAYSHC SKNKPGIALL 420 LINMSNQTSF SVSVLNDDSP YSDNYKLMNY KYGGIDKREE YHLTPKDGNI QSDVVLLNGT 480 PLKLTTSLEI PEMKPVIVDP SSPITVVPDS IVYVTIKDFK APA 540 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03662 | Glyco_hydro_79n | 4.0e-142 | 25 | 345 | 321 | + Glycosyl hydrolase family 79, N-terminal domain. Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| GO:0016798 | hydrolase activity, acting on glycosyl bonds |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| EMBL | CBI27258.1 | 0 | 13 | 522 | 12 | 521 | unnamed protein product [Vitis vinifera] |
| RefSeq | XP_002274743.1 | 0 | 13 | 522 | 10 | 519 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002315010.1 | 0 | 6 | 523 | 4 | 516 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002512114.1 | 0 | 25 | 523 | 28 | 529 | Heparanase precursor, putative [Ricinus communis] |
| RefSeq | XP_002512114.1 | 0.000000000004 | 55 | 103 | 539 | 587 | Heparanase precursor, putative [Ricinus communis] |
| Annotations - PDB Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| PDB | 3vo0_A | 0.0000000006 | 59 | 444 | 38 | 428 | A Chain A, Crystal Structure Of Chondroitin Polymerase From Escherichia Coli Strain K4 (K4cp) Complexed With Udp-Glcua And Udp |
| PDB | 3vnz_A | 0.0000000006 | 59 | 444 | 38 | 428 | A Chain A, Crystal Structure Of Chondroitin Polymerase From Escherichia Coli Strain K4 (K4cp) Complexed With Udp-Glcua And Udp |
| PDB | 3vny_A | 0.0000000006 | 59 | 444 | 38 | 428 | A Chain A, Crystal Structure Of Beta-Glucuronidase From Acidobacterium Capsulatum |
