| Basic Information | |
|---|---|
| Species | Manihot esculenta |
| Cazyme ID | cassava4.1_024120m |
| Family | GT47 |
| Protein Properties | Length: 424 Molecular Weight: 48736.7 Isoelectric Point: 8.9901 |
| Chromosome | Chromosome/Scaffold: 03368 Start: 65161 End: 69454 |
| Description | Exostosin family protein |
| View CDS | |
| Signature Domain Download full data set without filtering | |||
|---|---|---|---|
| Family | Start | End | Evalue |
| GT47 | 99 | 376 | 0 |
| ERNFKVYIYPDGDPNTFYQTPRKLTGKYASEGYFFQNIRESRFRTEDPNQAHLFFIPISCHKMRGKGTSYENMTIIVQNYVESLIAKYPYWNRTLGADHF FVTCHDVGVRATEGVPLLVKNAIRVVCSPSYDVGFIPHKDVALPQVLQPFALPAGGNDVENRTALGFWAGHRNSKIRVILARIWENDTELDISNNRISRA TGHLVYQKRFYRTKFCICPGGSQVNSARIADSIHYGCVPVILSNYYDLPFNDILDWRKFSVILKEQDVYQLKQVLKNI | |||
| Full Sequence |
|---|
| Protein Sequence Length: 424 Download |
| MTAGKLQQQA SKYMCSLKSS LLTLAILTLI SFTYLSINSL QSSSSSSSSF SPIVSSSVLK 60 QLQRGTERVT EEKGNSFDNE IPDLYHQPQI FKLNYEAMER NFKVYIYPDG DPNTFYQTPR 120 KLTGKYASEG YFFQNIRESR FRTEDPNQAH LFFIPISCHK MRGKGTSYEN MTIIVQNYVE 180 SLIAKYPYWN RTLGADHFFV TCHDVGVRAT EGVPLLVKNA IRVVCSPSYD VGFIPHKDVA 240 LPQVLQPFAL PAGGNDVENR TALGFWAGHR NSKIRVILAR IWENDTELDI SNNRISRATG 300 HLVYQKRFYR TKFCICPGGS QVNSARIADS IHYGCVPVIL SNYYDLPFND ILDWRKFSVI 360 LKEQDVYQLK QVLKNISDEE FVTLHKNLVE VQKHFQWNSP PIKYDAFHMV MYDLWLRHHV 420 IKY* 480 |
| Functional Domains Download unfiltered results here | ||||||||
|---|---|---|---|---|---|---|---|---|
| Cdd ID | Domain | E-Value | Start | End | Length | Domain Description | ||
| pfam03016 | Exostosin | 1.0e-57 | 98 | 376 | 298 | + Exostosin family. The EXT family is a family of tumour suppressor genes. Mutations of EXT1 on 8q24.1, EXT2 on 11p11-13, and EXT3 on 19p have been associated with the autosomal dominant disorder known as hereditary multiple exostoses (HME). This is the most common known skeletal dysplasia. The chromosomal locations of other EXT genes suggest association with other forms of neoplasia. EXT1 and EXT2 have both been shown to encode a heparan sulphate polymerase with both D-glucuronyl (GlcA) and N-acetyl-D-glucosaminoglycan (GlcNAC) transferase activities. The nature of the defect in heparan sulphate biosynthesis in HME is unclear. | ||
| Gene Ontology | |
|---|---|
| GO Term | Description |
| GO:0016020 | membrane |
| Annotations - NR Download unfiltered results here | |||||||
|---|---|---|---|---|---|---|---|
| Source | Hit ID | E-Value | Query Start | Query End | Hit Start | Hit End | Description |
| GenBank | ACU18220.1 | 0 | 16 | 423 | 10 | 409 | unknown [Glycine max] |
| RefSeq | NP_195517.1 | 0 | 10 | 423 | 15 | 425 | exostosin family protein [Arabidopsis thaliana] |
| RefSeq | XP_002266299.1 | 0 | 1 | 423 | 1 | 416 | PREDICTED: hypothetical protein [Vitis vinifera] |
| RefSeq | XP_002307304.1 | 0 | 14 | 423 | 1 | 406 | predicted protein [Populus trichocarpa] |
| RefSeq | XP_002522880.1 | 0 | 1 | 423 | 1 | 406 | catalytic, putative [Ricinus communis] |
| Metabolic Pathways | |||
|---|---|---|---|
| Pathway Name | Reaction | EC | Protein Name |
| xylogalacturonan biosynthesis | RXN-9589 | EC-2.4.2.41 | xylogalacturonan β-1,3-xylosyltransferase |
